CJC-1295 with DAC vs Cyclic Glycine-Proline
Well Studied vs Moderate Research
monitor Mechanism-based · 47% Both CJC-1295 with DAC and Cyclic Glycine-Proline affect insulin sensitivity or blood glucose. Monitor fasting glucose and HbA1c. Consider adding an insulin sensitizer (metformin/berberine).
Molecular Data
CJC-1295 with DAC Cyclic Glycine-Proline
Weight 3,647.28 Da 154.17 Da
Half-life 6-8 days Extended stability (more stable than linear GPE precursor)
Chain 30 amino acids 2 amino acids (cyclic)
Type GHRH analog with DAC Cyclic dipeptide (2,5-diketopiperazine)
Key Benefits
CJC-1295 with DAC
01 Convenient weekly dosing
02 Sustained GH/IGF-1 elevation
03 6-8 day half-life
04 Significant body composition changes
Cyclic Glycine-Proline
01 Neuroprotection and cognitive enhancement
02 IGF-1 optimization
03 Cardiovascular support
04 Metabolic health improvement
05 Blood-brain barrier penetration
06 Convenient oral administration
Dosing Protocols
CJC-1295 with DAC
1-2mg weekly / Once or twice weekly (e.g., Monday/Thursday for split dosing)
Conservative Anti-Aging 1mg Once weekly
Standard Protocol 2mg Once weekly
Split Dosing 1mg Twice weekly (Mon/Thu)
Loading Protocol 2mg first week, then 1mg Weekly
Cyclic Glycine-Proline
20-100 μg daily (or 300mg blackcurrant extract 2x daily) / Once daily, preferably in the morning
Side Effects
CJC-1295 with DAC
Water retention
Joint pain
Carpal tunnel symptoms
Cyclic Glycine-Proline
Contraindications
Diabetes history
Cancer history
Predisposed sleep apnea
Consult healthcare provider if taking IGF-1 or growth hormone medications
Limited long-term human data available
Not studied in pregnancy
Research Evidence
CJC-1295 with DAC Cyclic Glycine-Proline
Status Well Studied Moderate Research
References 4 studies 4 studies
Latest 2025 —
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.