CJC-1295 with DAC vs MOTS-c
Well Studied vs Well Studied
synergistic Mechanism-based · 51% CJC-1295 with DAC helps counteract the insulin-disrupting effects of MOTS-c. A smart combination — the insulin sensitizer mitigates metabolic side effects.
Molecular Data
CJC-1295 with DAC MOTS-c
Weight 3,647.28 Da 2,174.6 Da
Half-life 6-8 days ~30 minutes
Chain 30 amino acids 16 amino acids
Type GHRH analog with DAC Mitochondrial-derived peptide (MDP)
Key Benefits
CJC-1295 with DAC
01 Convenient weekly dosing
02 Sustained GH/IGF-1 elevation
03 6-8 day half-life
04 Significant body composition changes
MOTS-c
01 Enhanced insulin sensitivity (~30% improvement)
02 Improved glucose metabolism and tolerance
03 AMPK pathway activation
04 Mitochondrial function optimization
05 Exercise performance enhancement (12-15% improvement)
06 Potential lifespan extension (6.4% median increase in mice)
Dosing Protocols
CJC-1295 with DAC
1-2mg weekly / Once or twice weekly (e.g., Monday/Thursday for split dosing)
Conservative Anti-Aging 1mg Once weekly
Standard Protocol 2mg Once weekly
Split Dosing 1mg Twice weekly (Mon/Thu)
Loading Protocol 2mg first week, then 1mg Weekly
MOTS-c
Start 5mg daily, increase to 10-15mg based on goals / Daily for metabolic support, or 3x weekly for anti-aging
Metabolic health 5-10mg Once daily
Anti-aging protocol 15mg 3x weekly
Exercise performance 10-15mg Pre-workout
Conservative start 5mg Once daily
Side Effects
CJC-1295 with DAC
Water retention
Joint pain
Carpal tunnel symptoms
MOTS-c
Generally well-tolerated in animal studies with minimal side effects
Mild injection site reactions (redness, swelling)
Contraindications
Diabetes history
Cancer history
Predisposed sleep apnea
Pregnancy or breastfeeding
WADA prohibited substance (banned for athletic competition)
Limited long-term human safety data
Research Evidence
CJC-1295 with DAC MOTS-c
Status Well Studied Well Studied
References 4 studies 5 studies
Latest 2025 August 2025
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.