CJC-1295 (without DAC) vs Cyclic Glycine-Proline
Well Studied vs Moderate Research
monitor Mechanism-based · 47% Both CJC-1295 (without DAC) and Cyclic Glycine-Proline affect insulin sensitivity or blood glucose. Monitor fasting glucose and HbA1c. Consider adding an insulin sensitizer (metformin/berberine).
Molecular Data
CJC-1295 (without DAC) Cyclic Glycine-Proline
Weight 3,367.97 Da 154.17 Da
Half-life 30 minutes - 2 hours Extended stability (more stable than linear GPE precursor)
Chain 30 amino acids 2 amino acids (cyclic)
Type GHRH analog Cyclic dipeptide (2,5-diketopiperazine)
Key Benefits
CJC-1295 (without DAC)
01 Preserves natural GH pulsatility
02 Minimal side effects
03 No receptor desensitization
04 Precise GH release control
05 4x greater receptor affinity than native GHRH
Cyclic Glycine-Proline
01 Neuroprotection and cognitive enhancement
02 IGF-1 optimization
03 Cardiovascular support
04 Metabolic health improvement
05 Blood-brain barrier penetration
06 Convenient oral administration
Dosing Protocols
CJC-1295 (without DAC)
100-300mcg per injection / 2-3 times daily (morning, post-workout optional, bedtime)
Anti-Aging/Wellness 100mcg 2x daily (morning and bedtime)
Body Composition 100-150mcg 3x daily (morning, post-workout, bedtime)
Maximum GH Release 200mcg 2-3x daily with GHRP
Sleep Enhancement 100-200mcg Once at bedtime
Cyclic Glycine-Proline
20-100 μg daily (or 300mg blackcurrant extract 2x daily) / Once daily, preferably in the morning
Side Effects
CJC-1295 (without DAC)
Generally well-tolerated at recommended doses
Temporary facial flushing/warmth (5-10 minutes post-injection)
Cyclic Glycine-Proline
Contraindications
Active cancer (due to growth-promoting effects)
Diabetic retinopathy
Severe kidney disease
Pregnancy or breastfeeding
Consult healthcare provider if taking IGF-1 or growth hormone medications
Limited long-term human data available
Not studied in pregnancy
Research Evidence
CJC-1295 (without DAC) Cyclic Glycine-Proline
Status Well Studied Moderate Research
References 5 studies 4 studies
Latest November 2024 —
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.