GHK-Cu vs Melanotan II
Well Studied vs Well Studied
monitor Researched · 90% Both affect melanin production; use caution when combining.
Molecular Data
GHK-Cu Melanotan II
Weight 404.96 Da —
Half-life 0.5-2 hours ~2 hours
Chain 3 amino acids —
Type Copper tripeptide Synthetic alpha-MSH analog
Key Benefits
GHK-Cu
01 Enhanced collagen production (70% increase in type I and III)
02 Improved skin elasticity
03 Reduced fine lines and wrinkles
04 Accelerated wound healing
05 Hair growth stimulation
06 Antioxidant protection
Melanotan II
01 Rapid tanning without UV exposure
02 Enhanced sexual function and libido
03 Appetite suppression
04 Improved mood via melanocortin activation
05 Photoprotection through increased melanin
Dosing Protocols
GHK-Cu
0.5-2% topical or 1-3mg injectable / 1-2x daily
Systemic anti-aging 1-2mg 1x daily
Enhanced regeneration 2-3mg 1-2x daily
Melanotan II
Loading: Start 0.25mg daily, increase to 0.5-1mg; Maintenance: 0.5-1mg 2-3x weekly / Loading phase: Daily for first week, then tanning maintenance 2-3x weekly or as needed for sexual enhancement
Initial loading phase 0.25mg 1x daily
Tanning maintenance 0.5-1mg 2-3x weekly
Sexual enhancement 0.5-1mg As needed
Minimal side effects 0.1-0.25mg Every other day
Photoprotection 0.5mg 2x weekly
Side Effects
GHK-Cu
Mild skin irritation initially (usually resolves)
Increased photosensitivity
Melanotan II
Nausea (pre-treatment with antiemetics recommended)
Facial flushing
Temporary blood pressure elevation
Fatigue
Spontaneous erections
Contraindications
Known copper sensitivity or Wilson's disease
Active skin infections at application site
Pregnancy or breastfeeding (injectable)
History of melanoma or dysplastic nevi
Pregnancy or breastfeeding
Cardiovascular conditions
Uncontrolled hypertension
Research Evidence
GHK-Cu Melanotan II
Status Well Studied Well Studied
References 5 studies 4 studies
Latest July 2025 2024
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.