LL-37 vs TB-500
Well Studied vs Well Studied
synergistic Combined anti-inflammatory and healing effects.
Molecular Data
LL-37 TB-500
Weight — 4,963.44 Da
Half-life Short (rapid proteolytic degradation) ~2 hours
Chain 37 amino acids 43 amino acids
Type Cationic antimicrobial peptide Thymosin fragment
Key Benefits
LL-37
01 Direct wound healing acceleration
02 Broad-spectrum antimicrobial activity
03 Activity against resistant bacteria (MRSA, MDRPA)
04 Enhanced tissue regeneration
05 Immune modulation
06 Local antimicrobial protection
TB-500
01 Superior systemic tissue repair
02 Accelerated muscle, tendon, and ligament healing
03 Enhanced cell migration and angiogenesis
04 Comprehensive regenerative effects
05 Neuroprotective properties
Dosing Protocols
LL-37
0.5-1.6 mg/mL topical gel or 100-150 mcg injectable / Topical: Daily to twice weekly on wounds. Injectable: Once daily subcutaneous
Systemic immune support 100-150mcg Once daily
TB-500
2-5mg per injection (higher doses for serious injuries) / 2-3x weekly (e.g., Monday, Wednesday, Friday)
General tissue repair 2-3mg 2x weekly
Serious injury recovery 4-5mg 3x weekly
Athletic enhancement 2-3mg 2x weekly
Chronic conditions 3-4mg 2-3x weekly
Maintenance 2mg 1-2x weekly
Post-surgical recovery 3-5mg 3x weekly
Side Effects
LL-37
Generally well-tolerated
Mild injection site reactions (injectable)
Local irritation at application site (topical)
TB-500
Generally minimal side effects
Possible mild injection site reactions
Temporary fatigue in some users
Contraindications
Pre-existing hypersensitivity to peptides
Compromised immune status (relative contraindication)
Non-sterile wound environments
Active cancer treatment (due to angiogenic effects)
Pregnancy or breastfeeding
Immunosuppressive medications (consult provider)
WADA prohibited for competitive athletes
Research Evidence
LL-37 TB-500
Status Well Studied Well Studied
References 4 studies 4 studies
Latest 2025 March 2024
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.