MENT vs Oxandrolone
Emerging vs Well Studied
monitor Mechanism-based · 46% Both MENT and Oxandrolone suppress the HPTA axis. Combined suppression deepens shutdown and extends recovery time. Plan PCT accordingly and monitor LH/FSH/testosterone.
Molecular Data
MENT Oxandrolone
Weight 288.43 Da 306.44 Da
Half-life ~40 minutes (acetate ester) ~9-10 hours
Type 7-alpha-methyl-19-nortestosterone (C19H28O2) 17-alpha-alkylated anabolic-androgenic steroid (C19H30O3)
Key Benefits
MENT
01 Approximately 10x more potent than testosterone, allowing effective results at very low doses (5-25 mg/day)
02 Does not cause the sexual dysfunction associated with other 19-nor compounds like nandrolone
03 Can potentially serve as a standalone base, replacing testosterone in hormone replacement protocols
04 Rapid clearance of the acetate ester allows quick dose adjustments and fast resolution of side effects upon discontinuation
05 Powerful lean mass accretion and strength gains relative to dose
06 Under investigation as a reversible male hormonal contraceptive
07 Resistance to 5-alpha reductase means it does not convert to DHT, potentially sparing hair follicles from direct DHT-mediated damage
08 Robust suppression of gonadotropins (LH/FSH), which is therapeutically useful in contraceptive applications
Oxandrolone
01 Promotes lean muscle mass gains with minimal water retention
02 Supports recovery of lost body weight following surgery, trauma, or chronic illness
03 Reduces bone pain associated with osteoporosis and improves bone mineral density
04 Does not aromatize to estrogen, avoiding estrogen-related side effects
05 Well-studied safety profile in women, children, and burn patients
06 Enhances nitrogen retention and protein synthesis during caloric deficit
07 Attenuates glucocorticoid-induced catabolism in post-surgical and burn patients
08 Lower androgenic potency compared to most oral anabolic steroids
Dosing Protocols
MENT
5-25 mg/day (acetate) / Daily or split into 2x daily (acetate ester)
TRT Replacement - Low Dose 5-10 mg/day Daily (or split into 2 injections per day)
Moderate Anabolic Protocol 10-15 mg/day Split into 2 injections per day
Higher Dose - Advanced 15-25 mg/day Split into 2 injections per day
Oxandrolone
20-50 mg/day (male), 5-20 mg/day (female) / Split into 2 doses daily (morning and evening)
Side Effects
MENT
Estrogen management difficulty -- 7-alpha-methyl-estradiol is harder to control with conventional aromatase inhibitors
Water retention and bloating, particularly at doses above 10 mg/day
Elevated blood pressure, often linked to water retention and estrogenic load
Mood changes including irritability, emotional sensitivity, or anxiety (frequently estrogen-related)
Profoundly suppressive of the HPG axis -- LH and FSH driven to near-zero even at low doses
Injection frequency burden (daily or twice-daily with acetate ester)
Mild acne and oily skin
Increased appetite
Oxandrolone
HDL cholesterol suppression (dose-dependent, most significant lipid effect)
LDL cholesterol elevation
Mild hepatic stress (elevated liver enzymes ALT/AST)
Suppression of endogenous testosterone production
Mild headaches
Nausea or gastrointestinal discomfort
Changes in libido (increase or decrease depending on hormonal context)
Oily skin and mild acne
Contraindications
Prostate cancer (active or history of hormone-sensitive prostate cancer)
Breast cancer in males or females
Pregnancy or potential for pregnancy
Severe hepatic impairment
Polycythemia (hematocrit above 54% at baseline)
Uncontrolled hypertension or severe cardiovascular disease
Uncontrolled heart failure
Known hypersensitivity to trestolone or any formulation components
Known or suspected prostate cancer
Breast cancer in males
Breast cancer with hypercalcemia in females
Pregnancy (Category X - known to cause fetal harm)
Nephrosis or nephrotic phase of nephritis
Hypercalcemia
Severe hepatic dysfunction or active liver disease
Hypersensitivity to oxandrolone or any formulation component
Research Evidence
MENT Oxandrolone
Status Emerging Well Studied
References 5 studies 5 studies
Latest 2002 September 2023
FDA Approved No Yes
This comparison is for educational and research purposes only. Consult a healthcare professional before use.