Humanin and MOTS-c Interaction

Synergistic
Researched 95% confidence

Humanin and MOTS-c have a synergistic interaction with 95% confidence. Both are mitochondria-derived peptides with complementary longevity and metabolic benefits. These compounds primarily affect different organ systems.

Compound Profiles

Humanin

Mitochondria-Derived Peptide | HN

Humanin exerts its effects through multiple mechanisms. It interacts with cell surface receptors including FPRL1 and CNTFR, activating PI3K/AKT signaling pathways that promote cell survival.

Half-life: ~30 minutes (mice), >4 hours (rats) Typical dose: 1-5 mg per injection (0.5-2 mg for HNG analog) longevity, cognitive
carcinogenic riskteratogenic
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MOTS-c

Mitochondrial-Derived Peptide | Metabolic Regulator

Inhibits the folate cycle leading to AMPK activation. Under metabolic stress, translocates to nucleus to bind stress-response transcription factors, regulating genes involved in metabolism, insulin sensitivity, and cellular adaptation.

Half-life: ~30 minutes Typical dose: Start 5mg daily, increase to 10-15mg based on goals longevity, metabolic
ampknrf2 insulin disruptinginsulin sensitizingteratogenic
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Combined Organ Load

Brain
low
Pancreas
low

Shared Safety Flags

2x 2 compounds share the teratogenic safety flag (Humanin, MOTS-c). Monitor accordingly.

Frequently Asked Questions

Can I take Humanin with MOTS-c?

Yes, Humanin and MOTS-c can generally be taken together. Both are mitochondria-derived peptides with complementary longevity and metabolic benefits.

Is Humanin and MOTS-c safe together?

Based on documented research, this combination is considered synergistic. However, shared safety flags include: teratogenic. Monitor accordingly.

What are the interactions between Humanin and MOTS-c?

Both are mitochondria-derived peptides with complementary longevity and metabolic benefits. This assessment has 95% confidence and is based on documented research data.

How should I time Humanin and MOTS-c?

Humanin has a half-life of ~30 minutes (mice), >4 hours (rats) and MOTS-c has a half-life of ~30 minutes. No specific timing requirements identified for this combination, but separating administration can help monitor individual effects.

Check this pair in the full Interaction Checker Full comparison: Humanin vs MOTS-c

This interaction analysis is compiled from research literature and pharmacological mechanism data. Always consult a healthcare professional before combining compounds.