Oxandrolone and RAD-140 Interaction

Avoid
Mechanism-based 53% confidence

Oxandrolone and RAD-140 have a potentially harmful interaction with 53% confidence. Both Oxandrolone and RAD-140 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. Both compounds affect the gonads and liver and heart, so monitoring these systems is recommended.

Compound Profiles

Oxandrolone

Oral Anabolic Steroid | Lean Mass & Recovery

Oxandrolone exerts its anabolic effects primarily through binding to the intracellular androgen receptor (AR), promoting nitrogen retention and protein synthesis in skeletal muscle tissue. As a DHT derivative, it cannot be converted to estrogen by the aromatase enzyme, which means it does not cause estrogen-mediated water retention or gynecomastia.

Half-life: ~9-10 hours Typical dose: 20-50 mg/day (male), 5-20 mg/day (female) anabolic, healing
5 alpha reductaseandrogen receptoraromataseshbg androgeniccarcinogenic riskhepatotoxichpta suppressive
View full profile

RAD-140

Selective Androgen Receptor Modulator | Investigational SARM

RAD-140 binds to the androgen receptor (AR) with high affinity and selectivity, functioning as a full agonist in muscle and bone tissue while exhibiting minimal agonist activity in the prostate and other androgen-sensitive tissues. This tissue selectivity is achieved through differential cofactor recruitment: upon binding to the AR, RAD-140 induces a conformational change that favors interaction with coactivators predominantly expressed in skeletal muscle and bone, rather than those prevalent in prostate or sebaceous glands.

Half-life: ~60 hours Typical dose: 10-20 mg/day sarm, anabolic
androgen receptorepo receptor androgenicblood pressure raisingcarcinogenic riskcrosses bbb
View full profile

Combined Organ Load

Gonads
elevated
Liver
elevated
Heart
moderate
Blood Vessels
low

Shared Safety Flags

2x 2 androgenic compounds (Oxandrolone, RAD-140). Additive androgenic load — increased risk of hair loss, acne, prostate effects.
2x 2 compounds share the carcinogenic-risk safety flag (Oxandrolone, RAD-140). Monitor accordingly.
2x 2 hepatotoxic compounds (Oxandrolone, RAD-140). Liver damage risk significantly increased. Include liver support (TUDCA/NAC) and monitor ALT/AST.
2x 2 HPTA-suppressive compounds (Oxandrolone, RAD-140). Deep hormonal shutdown expected — plan extended PCT.
2x 2 compounds disrupt lipids (Oxandrolone, RAD-140). Get lipid panel mid-cycle — consider adding lipid support.

Frequently Asked Questions

Can I take Oxandrolone with RAD-140?

Combining Oxandrolone with RAD-140 is not recommended. Both Oxandrolone and RAD-140 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently.

Is Oxandrolone and RAD-140 safe together?

This combination carries significant risk. Both Oxandrolone and RAD-140 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. Consult a healthcare professional before combining.

What are the interactions between Oxandrolone and RAD-140?

Both Oxandrolone and RAD-140 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. This assessment has 53% confidence and is inferred from pharmacological mechanism analysis.

How should I time Oxandrolone and RAD-140?

Oxandrolone has a half-life of ~9-10 hours and RAD-140 has a half-life of ~60 hours. No specific timing requirements identified for this combination, but separating administration can help monitor individual effects.

Check this pair in the full Interaction Checker Full comparison: Oxandrolone vs RAD-140

This interaction analysis is compiled from research literature and pharmacological mechanism data. This assessment is inferred from known mechanisms and may not reflect all real-world outcomes. Always consult a healthcare professional before combining compounds.