Oxandrolone and Raloxifene Interaction

Avoid
Mechanism-based 64% confidence

Oxandrolone and Raloxifene have a potentially harmful interaction with 64% confidence. Both Oxandrolone and Raloxifene carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. Both compounds affect the gonads, so monitoring these systems is recommended.

Compound Profiles

Oxandrolone

Oral Anabolic Steroid | Lean Mass & Recovery

Oxandrolone exerts its anabolic effects primarily through binding to the intracellular androgen receptor (AR), promoting nitrogen retention and protein synthesis in skeletal muscle tissue. As a DHT derivative, it cannot be converted to estrogen by the aromatase enzyme, which means it does not cause estrogen-mediated water retention or gynecomastia.

Half-life: ~9-10 hours Typical dose: 20-50 mg/day (male), 5-20 mg/day (female) anabolic, healing
5 alpha reductaseandrogen receptoraromataseshbg androgeniccarcinogenic riskhepatotoxichpta suppressive
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Raloxifene

Selective Estrogen Receptor Modulator | Gynecomastia & Bone Health

Raloxifene binds to both estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta), producing tissue-dependent agonist or antagonist effects determined by the local complement of coactivator and corepressor proteins. In breast tissue, raloxifene functions as a potent estrogen antagonist, blocking estradiol-mediated proliferative signaling with high selectivity.

Half-life: ~28 hours Typical dose: 60mg oral daily pct
estrogen receptor hepatotoxicpct agentteratogenic
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Combined Organ Load

Gonads
moderate
Liver
moderate
Heart
low
Blood Vessels
low
Pituitary
low

Shared Safety Flags

2x 2 hepatotoxic compounds (Oxandrolone, Raloxifene). Liver damage risk significantly increased. Include liver support (TUDCA/NAC) and monitor ALT/AST.
2x 2 compounds share the teratogenic safety flag (Oxandrolone, Raloxifene). Monitor accordingly.

Frequently Asked Questions

Can I take Oxandrolone with Raloxifene?

Combining Oxandrolone with Raloxifene is not recommended. Both Oxandrolone and Raloxifene carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently.

Is Oxandrolone and Raloxifene safe together?

This combination carries significant risk. Both Oxandrolone and Raloxifene carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. Consult a healthcare professional before combining.

What are the interactions between Oxandrolone and Raloxifene?

Both Oxandrolone and Raloxifene carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. This assessment has 64% confidence and is inferred from pharmacological mechanism analysis.

How should I time Oxandrolone and Raloxifene?

Oxandrolone has a half-life of ~9-10 hours and Raloxifene has a half-life of ~28 hours. No specific timing requirements identified for this combination, but separating administration can help monitor individual effects.

Check this pair in the full Interaction Checker Full comparison: Oxandrolone vs Raloxifene

This interaction analysis is compiled from research literature and pharmacological mechanism data. This assessment is inferred from known mechanisms and may not reflect all real-world outcomes. Always consult a healthcare professional before combining compounds.