GHK-Cu vs TB-500 (Ac-LKKTETQ)
Well Studied vs Moderate Research
synergistic Both support wound healing and tissue repair through different pathways.
Molecular Data
GHK-Cu TB-500 (Ac-LKKTETQ)
Weight 404.96 Da 844 Da
Half-life 0.5-2 hours Not precisely established; effects persist longer than 24 hours
Chain 3 amino acids 7 amino acids
Type Copper tripeptide Acetylated heptapeptide
Key Benefits
GHK-Cu
01 Enhanced collagen production (70% increase in type I and III)
02 Improved skin elasticity
03 Reduced fine lines and wrinkles
04 Accelerated wound healing
05 Hair growth stimulation
06 Antioxidant protection
TB-500 (Ac-LKKTETQ)
01 Promotes wound healing
02 Enhances cell migration
03 Supports angiogenesis (new blood vessel formation)
04 Reduces inflammation
05 Promotes keratinocyte migration
06 Supports collagen deposition
07 Enhances tissue repair
08 Active region of thymosin beta-4
Dosing Protocols
GHK-Cu
0.5-2% topical or 1-3mg injectable / 1-2x daily
Systemic anti-aging 1-2mg 1x daily
Enhanced regeneration 2-3mg 1-2x daily
TB-500 (Ac-LKKTETQ)
2-2.5mg per injection / 2x weekly (e.g., Monday and Thursday)
Loading phase 2-2.5 mg 2x weekly for 4-6 weeks
Maintenance 2 mg Weekly or bi-weekly
Side Effects
GHK-Cu
Mild skin irritation initially (usually resolves)
Increased photosensitivity
TB-500 (Ac-LKKTETQ)
Injection site reactions
Mild fatigue
Head rush (reported)
Contraindications
Known copper sensitivity or Wilson's disease
Active skin infections at application site
Pregnancy or breastfeeding (injectable)
Not authorized for medicinal use
Active cancer (theoretical concern)
Pregnancy or breastfeeding
Prohibited by WADA in sports
Research Evidence
GHK-Cu TB-500 (Ac-LKKTETQ)
Status Well Studied Moderate Research
References 3 studies 4 studies
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.