IGF-1 LR3 vs TB-500 (Ac-LKKTETQ)
limited vs Moderate Research
compatible Different mechanisms; may complement for tissue growth.
Molecular Data
IGF-1 LR3 TB-500 (Ac-LKKTETQ)
Weight — 844 Da
Half-life 20-30 hours Not precisely established; effects persist longer than 24 hours
Chain 83 amino acids 7 amino acids
Type Synthetic IGF-1 analog Acetylated heptapeptide
Key Benefits
IGF-1 LR3
01 Approximately 3x more potent than native IGF-1
02 Promotes muscle hypertrophy and hyperplasia in animal models
03 15-20% lean mass gains observed in 4-week rat studies
04 Anti-catabolic effects preserve muscle during cachexia
05 20-30 hour half-life for sustained effects
TB-500 (Ac-LKKTETQ)
01 Promotes wound healing
02 Enhances cell migration
03 Supports angiogenesis (new blood vessel formation)
04 Reduces inflammation
05 Promotes keratinocyte migration
06 Supports collagen deposition
07 Enhances tissue repair
08 Active region of thymosin beta-4
Dosing Protocols
IGF-1 LR3
20-100 mcg daily (start low at 20-30 mcg) / Once daily, or split AM/PM for higher doses
Beginner Protocol 20-30mcg Once daily post-workout
Intermediate 40-60mcg Once daily
Advanced 80-100mcg Once or split AM/PM
Women's Protocol 10-20mcg Once daily
TB-500 (Ac-LKKTETQ)
2-2.5mg per injection / 2x weekly (e.g., Monday and Thursday)
Loading phase 2-2.5 mg 2x weekly for 4-6 weeks
Maintenance 2 mg Weekly or bi-weekly
Side Effects
IGF-1 LR3
Hypoglycemia (lasting up to 30 hours) - CRITICAL
Water retention
Joint stiffness
Muscle soreness
Increased pump during workouts
TB-500 (Ac-LKKTETQ)
Injection site reactions
Mild fatigue
Head rush (reported)
Contraindications
NEVER approved for human use - research chemical only
Cancer history or undiagnosed growths
May cause organ hypertrophy (heart, intestines)
WADA prohibited - causes failed drug tests
Not authorized for medicinal use
Active cancer (theoretical concern)
Pregnancy or breastfeeding
Prohibited by WADA in sports
Research Evidence
IGF-1 LR3 TB-500 (Ac-LKKTETQ)
Status limited Moderate Research
References 4 studies 4 studies
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.