IGF-1 LR3 vs MGF
limited vs limited
monitor Researched · 90% Both target IGF-1 pathways; combining risks receptor overstimulation.
Molecular Data
IGF-1 LR3 MGF
Weight — ~2,888 Da
Half-life 20-30 hours ~5-7 minutes
Chain 83 amino acids 24 amino acids
Type Synthetic IGF-1 analog IGF-1Ec splice variant C-terminal peptide
Key Benefits
IGF-1 LR3
01 Approximately 3x more potent than native IGF-1
02 Promotes muscle hypertrophy and hyperplasia in animal models
03 15-20% lean mass gains observed in 4-week rat studies
04 Anti-catabolic effects preserve muscle during cachexia
05 20-30 hour half-life for sustained effects
MGF
01 Satellite cell activation for muscle repair
02 Recovery support following mechanical stress
03 Localized tissue regeneration
04 Natural upregulation after exercise
Dosing Protocols
IGF-1 LR3
20-100 mcg daily (start low at 20-30 mcg) / Once daily, or split AM/PM for higher doses
Beginner Protocol 20-30mcg Once daily post-workout
Intermediate 40-60mcg Once daily
Advanced 80-100mcg Once or split AM/PM
Women's Protocol 10-20mcg Once daily
MGF
100-300mcg per injection / Daily, immediately post-workout
Standard Protocol 100-300mcg Daily, post-workout
Progressive Titration 100mcg → 300mcg Daily, increasing weekly
Localized Recovery 200-300mcg Immediately post-workout
Side Effects
IGF-1 LR3
Hypoglycemia (lasting up to 30 hours) - CRITICAL
Water retention
Joint stiffness
Muscle soreness
Increased pump during workouts
MGF
Injection site soreness
Mild fatigue
Contraindications
NEVER approved for human use - research chemical only
Cancer history or undiagnosed growths
May cause organ hypertrophy (heart, intestines)
WADA prohibited - causes failed drug tests
Any history of cancer or neoplastic disease
Pregnancy or breastfeeding
Uncontrolled diabetes
Research Evidence
IGF-1 LR3 MGF
Status limited limited
References 4 studies 2 studies
Latest November 2024 —
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.