Sermorelin vs Tesamorelin
Well Studied vs FDA Approved
monitor Researched · 90% Similar mechanism; risk of excessive effects at higher doses.
Molecular Data
Sermorelin Tesamorelin
Weight 3,358 Da 5,135.9 Da
Half-life 10-12 minutes 26-38 minutes
Chain 29 amino acids 44 amino acids
Type GHRH analog GHRH analog
Key Benefits
Sermorelin
01 FDA-proven efficacy
02 Maintains natural GH pulsatile patterns
03 Preserves pituitary function
04 1.26kg lean mass increase documented in elderly
05 IGF-1 mediated anabolic effects
06 Allows natural feedback regulation
Tesamorelin
01 FDA-approved formulation
02 Selective visceral fat targeting (15-20% reduction)
03 Proven clinical efficacy
04 Standardized dosing
05 37% liver fat reduction in NAFLD
06 Preserved subcutaneous fat
Dosing Protocols
Sermorelin
200-300mcg per dose (up to 500mcg for athletic performance) / Once daily at bedtime (aligns with natural GH pulse)
Anti-aging/Longevity 200-300mcg Once at bedtime
Athletic Performance 300-500mcg Once at bedtime
Body Composition 200mcg 5 days weekly
Combination Therapy 200mcg + GHRP Once daily
Tesamorelin
1.4-2mg daily (FDA-approved: 2mg for HIV lipodystrophy) / Once daily (evening preferred for GH rhythm)
HIV Lipodystrophy (FDA-approved) 1.4mg Once daily
Visceral Fat Reduction 2mg Once daily
Anti-aging/Body Composition 1-2mg 5-7x weekly
NAFLD Treatment 2mg Once daily (12 months)
Cognitive Enhancement 1mg Once daily (20 weeks)
Side Effects
Sermorelin
Injection site reactions (16.7% of patients - generally mild)
Nasal irritation (intranasal route)
Tesamorelin
Injection site reactions (17%)
Joint pain (13%)
Water retention
Contraindications
Active malignancy
Pituitary tumors
Pregnancy
Active malignancy
Pituitary disorders
Pregnancy
Research Evidence
Sermorelin Tesamorelin
Status Well Studied FDA Approved
References 5 studies 5 studies
Latest November 2024 June 2025
FDA Approved No Yes
This comparison is for educational and research purposes only. Consult a healthcare professional before use.