Finasteride and MK-677 Interaction

Avoid
Mechanism-based 64% confidence

Finasteride and MK-677 have a potentially harmful interaction with 64% confidence. Both Finasteride and MK-677 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. These compounds primarily affect different organ systems.

Compound Profiles

Finasteride

5-Alpha Reductase Inhibitor | DHT Blocker for Hair Loss & BPH

Finasteride competitively and selectively inhibits the Type II isoform of the enzyme 5-alpha reductase, which is predominantly found in hair follicles, the prostate, and the liver. This enzyme converts testosterone into dihydrotestosterone (DHT).

Half-life: 6-8 hours (DHT suppression persists ~24 hours) Typical dose: 1mg/day (hair loss) or 5mg/day (BPH) hair loss
5 alpha reductase estrogenichepatotoxicteratogenic
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MK-677

Ghrelin Receptor Agonist | Oral Growth Hormone Secretagogue

Selectively binds GHS-R1a receptors in hypothalamus and pituitary, triggering pulsatile growth hormone release while maintaining natural circadian patterns..

Half-life: ~24 hours Typical dose: Start 12.5mg daily, increase to 25mg based on tolerance growth hormone, weight loss, sleep
ghrelin receptor blood pressure raisingcarcinogenic riskhepatotoxicinsulin disrupting
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Combined Organ Load

Skin
low
Brain
low
GI Tract
low
Pituitary
low

Shared Safety Flags

2x 2 hepatotoxic compounds (Finasteride, MK-677). Liver damage risk significantly increased. Include liver support (TUDCA/NAC) and monitor ALT/AST.
2x 2 compounds share the teratogenic safety flag (Finasteride, MK-677). Monitor accordingly.

Frequently Asked Questions

Can I take Finasteride with MK-677?

Combining Finasteride with MK-677 is not recommended. Both Finasteride and MK-677 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently.

Is Finasteride and MK-677 safe together?

This combination carries significant risk. Both Finasteride and MK-677 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. Consult a healthcare professional before combining.

What are the interactions between Finasteride and MK-677?

Both Finasteride and MK-677 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. This assessment has 64% confidence and is inferred from pharmacological mechanism analysis.

How should I time Finasteride and MK-677?

Finasteride has a half-life of 6-8 hours (DHT suppression persists ~24 hours) and MK-677 has a half-life of ~24 hours. No specific timing requirements identified for this combination, but separating administration can help monitor individual effects.

Check this pair in the full Interaction Checker Full comparison: Finasteride vs MK-677

This interaction analysis is compiled from research literature and pharmacological mechanism data. This assessment is inferred from known mechanisms and may not reflect all real-world outcomes. Always consult a healthcare professional before combining compounds.