LGD-4033 and Naltrexone Interaction

Avoid
Mechanism-based 64% confidence

LGD-4033 and Naltrexone have a potentially harmful interaction with 64% confidence. Both LGD-4033 and Naltrexone carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. These compounds primarily affect different organ systems.

Compound Profiles

LGD-4033

Selective Androgen Receptor Modulator | Lean Mass

LGD-4033 binds to the androgen receptor with high affinity (Ki of approximately 1 nM), functioning as a potent and selective agonist in muscle and bone tissue. Like other SARMs, its tissue selectivity is mediated by differential cofactor recruitment: upon binding to the AR, LGD-4033 induces a receptor conformation that preferentially recruits coactivators expressed in skeletal muscle and bone, while showing minimal agonist activity in androgen-sensitive tissues such as the prostate and skin.

Half-life: ~24-36 hours Typical dose: 5-10 mg/day sarm, anabolic
androgen receptorepo receptor androgenicblood pressure raisingcarcinogenic riskestrogenic
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Naltrexone

Opioid Antagonist | Low-Dose Anti-Inflammatory & Immune Modulation

At low doses (1-4.5 mg), naltrexone produces a brief nocturnal blockade of opioid receptors that lasts approximately 4-6 hours.

Half-life: ~4 hours Typical dose: 1.5-4.5 mg/day (LDN) immune, longevity
opioid receptor hepatotoxic
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Combined Organ Load

Gonads
moderate
Liver
moderate
Heart
low

Shared Safety Flags

2x 2 hepatotoxic compounds (LGD-4033, Naltrexone). Liver damage risk significantly increased. Include liver support (TUDCA/NAC) and monitor ALT/AST.

Frequently Asked Questions

Can I take LGD-4033 with Naltrexone?

Combining LGD-4033 with Naltrexone is not recommended. Both LGD-4033 and Naltrexone carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently.

Is LGD-4033 and Naltrexone safe together?

This combination carries significant risk. Both LGD-4033 and Naltrexone carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. Consult a healthcare professional before combining.

What are the interactions between LGD-4033 and Naltrexone?

Both LGD-4033 and Naltrexone carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. This assessment has 64% confidence and is inferred from pharmacological mechanism analysis.

How should I time LGD-4033 and Naltrexone?

LGD-4033 has a half-life of ~24-36 hours and Naltrexone has a half-life of ~4 hours. No specific timing requirements identified for this combination, but separating administration can help monitor individual effects.

Check this pair in the full Interaction Checker Full comparison: LGD-4033 vs Naltrexone

This interaction analysis is compiled from research literature and pharmacological mechanism data. This assessment is inferred from known mechanisms and may not reflect all real-world outcomes. Always consult a healthcare professional before combining compounds.