MK-677 and Modafinil Interaction

Avoid
Mechanism-based 64% confidence

MK-677 and Modafinil have a potentially harmful interaction with 64% confidence. Both MK-677 and Modafinil carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. Both compounds affect the brain, so monitoring these systems is recommended.

Compound Profiles

MK-677

Ghrelin Receptor Agonist | Oral Growth Hormone Secretagogue

Selectively binds GHS-R1a receptors in hypothalamus and pituitary, triggering pulsatile growth hormone release while maintaining natural circadian patterns..

Half-life: ~24 hours Typical dose: Start 12.5mg daily, increase to 25mg based on tolerance growth hormone, weight loss, sleep
ghrelin receptor blood pressure raisingcarcinogenic riskhepatotoxicinsulin disrupting
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Modafinil

Eugeroic | Wakefulness & Cognitive Enhancement

The exact mechanism of action of modafinil is not fully understood, which distinguishes it from most prescription stimulants. The primary mechanism appears to involve inhibition of the dopamine transporter (DAT), leading to increased extracellular dopamine concentrations in the nucleus accumbens and cortical regions.

Half-life: ~12-15 hours Typical dose: 100-200 mg/day cognitive
dopamine receptorgabaserotonin receptor blood pressure raisingcardiotoxichepatotoxicteratogenic
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Combined Organ Load

Brain
low
GI Tract
low
Pituitary
low

Shared Safety Flags

2x 2 compounds raise blood pressure (MK-677, Modafinil). Monitor BP daily and consider cardiovascular support.
2x 2 hepatotoxic compounds (MK-677, Modafinil). Liver damage risk significantly increased. Include liver support (TUDCA/NAC) and monitor ALT/AST.
2x 2 compounds share the teratogenic safety flag (MK-677, Modafinil). Monitor accordingly.

Frequently Asked Questions

Can I take MK-677 with Modafinil?

Combining MK-677 with Modafinil is not recommended. Both MK-677 and Modafinil carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently.

Is MK-677 and Modafinil safe together?

This combination carries significant risk. Both MK-677 and Modafinil carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. Consult a healthcare professional before combining.

What are the interactions between MK-677 and Modafinil?

Both MK-677 and Modafinil carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. This assessment has 64% confidence and is inferred from pharmacological mechanism analysis.

How should I time MK-677 and Modafinil?

MK-677 has a half-life of ~24 hours and Modafinil has a half-life of ~12-15 hours. No specific timing requirements identified for this combination, but separating administration can help monitor individual effects.

Check this pair in the full Interaction Checker Full comparison: MK-677 vs Modafinil

This interaction analysis is compiled from research literature and pharmacological mechanism data. This assessment is inferred from known mechanisms and may not reflect all real-world outcomes. Always consult a healthcare professional before combining compounds.