MOTS-c and SS-31 Interaction

Synergistic
Researched 95% confidence

MOTS-c and SS-31 have a synergistic interaction with 95% confidence. Both are mitochondrial peptides with complementary mechanisms. Both compounds affect the pancreas, so monitoring these systems is recommended.

Compound Profiles

MOTS-c

Mitochondrial-Derived Peptide | Metabolic Regulator

Inhibits the folate cycle leading to AMPK activation. Under metabolic stress, translocates to nucleus to bind stress-response transcription factors, regulating genes involved in metabolism, insulin sensitivity, and cellular adaptation.

Half-life: ~30 minutes Typical dose: Start 5mg daily, increase to 10-15mg based on goals longevity, metabolic
ampknrf2 insulin disruptinginsulin sensitizingteratogenic
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SS-31

Mitochondrial-Targeted Peptide | Cardiolipin Protector

Selectively binds to cardiolipin in inner mitochondrial membrane, preventing lipid peroxidation and optimizing electron transport chain function. This improves ATP production and reduces oxidative damage at the mitochondrial level.

Half-life: ~2 hours Typical dose: 5-10mg general support, 10-40mg clinical/performance protocols longevity, metabolic
teratogenic
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Combined Organ Load

Pancreas
low

Shared Safety Flags

2x 2 compounds share the teratogenic safety flag (MOTS-c, SS-31). Monitor accordingly.

Frequently Asked Questions

Can I take MOTS-c with SS-31?

Yes, MOTS-c and SS-31 can generally be taken together. Both are mitochondrial peptides with complementary mechanisms.

Is MOTS-c and SS-31 safe together?

Based on documented research, this combination is considered synergistic. However, shared safety flags include: teratogenic. Monitor accordingly.

What are the interactions between MOTS-c and SS-31?

Both are mitochondrial peptides with complementary mechanisms. This assessment has 95% confidence and is based on documented research data.

How should I time MOTS-c and SS-31?

MOTS-c has a half-life of ~30 minutes and SS-31 has a half-life of ~2 hours. No specific timing requirements identified for this combination, but separating administration can help monitor individual effects.

Check this pair in the full Interaction Checker Full comparison: MOTS-c vs SS-31

This interaction analysis is compiled from research literature and pharmacological mechanism data. Always consult a healthcare professional before combining compounds.