GHK-Cu vs SS-31
Well Studied vs Well Studied
compatible Different mechanisms; no conflicts.
Molecular Data
GHK-Cu SS-31
Weight 404.96 Da —
Half-life 0.5-2 hours ~2 hours
Chain 3 amino acids —
Type Copper tripeptide Aromatic-cationic tetrapeptide
Key Benefits
GHK-Cu
01 Enhanced collagen production (70% increase in type I and III)
02 Improved skin elasticity
03 Reduced fine lines and wrinkles
04 Accelerated wound healing
05 Hair growth stimulation
06 Antioxidant protection
SS-31
01 Directly protects mitochondria
02 Improves cellular energy production (ATP)
03 Reduces oxidative damage
04 Enhances exercise capacity
05 Excellent safety profile in clinical trials
06 Cardioprotective effects
Dosing Protocols
GHK-Cu
0.5-2% topical or 1-3mg injectable / 1-2x daily
Systemic anti-aging 1-2mg 1x daily
Enhanced regeneration 2-3mg 1-2x daily
SS-31
5-10mg general support, 10-40mg clinical/performance protocols / Once daily (morning or pre-workout for athletic use)
General mitochondrial support 5-10mg Once daily
Athletic performance 10-20mg Once daily pre-workout
Clinical protocols 40mg Once daily
Acute cardioprotection 0.25mg/kg/hr Continuous infusion
Side Effects
GHK-Cu
Mild skin irritation initially (usually resolves)
Increased photosensitivity
SS-31
Excellent safety profile in clinical trials
No significant side effects reported at therapeutic doses
Mild injection site reactions possible
Safe for long-term use based on current data
Contraindications
Known copper sensitivity or Wilson's disease
Active skin infections at application site
Pregnancy or breastfeeding (injectable)
Known hypersensitivity to peptides
Pregnancy or breastfeeding (limited data)
Research Evidence
GHK-Cu SS-31
Status Well Studied Well Studied
References 3 studies 4 studies
Latest — February 2024
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.