Humanin vs SS-31
Moderate Research vs Well Studied
synergistic Both target mitochondrial function; may have additive benefits for cellular health.
Molecular Data
Humanin SS-31
Weight 2,687 Da —
Half-life ~30 minutes (mice), >4 hours (rats) ~2 hours
Chain 24 amino acids —
Type Mitochondria-derived peptide Aromatic-cationic tetrapeptide
Key Benefits
Humanin
01 Potent neuroprotection against Alzheimer's and Parkinson's pathology
02 Extended lifespan in animal models (C. elegans)
03 Improved metabolic healthspan parameters
04 Reduced inflammatory markers
05 Cytoprotective effects across multiple cell types
06 Anti-apoptotic activity
07 Mitochondrial optimization and biogenesis
08 Protection against oxidative stress
SS-31
01 Directly protects mitochondria
02 Improves cellular energy production (ATP)
03 Reduces oxidative damage
04 Enhances exercise capacity
05 Excellent safety profile in clinical trials
06 Cardioprotective effects
Dosing Protocols
Humanin
1-5 mg per injection (0.5-2 mg for HNG analog) / 2-3 times weekly for sustained mitochondrial support
Neuroprotection 1-5 mg 2-3x weekly
Longevity/Anti-aging 1-3 mg 2x weekly
HNG analog 0.5-2 mg 2x weekly
SS-31
5-10mg general support, 10-40mg clinical/performance protocols / Once daily (morning or pre-workout for athletic use)
General mitochondrial support 5-10mg Once daily
Athletic performance 10-20mg Once daily pre-workout
Clinical protocols 40mg Once daily
Acute cardioprotection 0.25mg/kg/hr Continuous infusion
Side Effects
Humanin
Injection site reactions
Mild fatigue initially
Headache (rare)
SS-31
Excellent safety profile in clinical trials
No significant side effects reported at therapeutic doses
Mild injection site reactions possible
Safe for long-term use based on current data
Contraindications
Active cancer (theoretical concern with anti-apoptotic effects)
Pregnancy or breastfeeding
Hypersensitivity to peptide components
Known hypersensitivity to peptides
Pregnancy or breastfeeding (limited data)
Research Evidence
Humanin SS-31
Status Moderate Research Well Studied
References 4 studies 4 studies
Latest — February 2024
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.