Epitalon vs Humanin
Well Studied vs Moderate Research
compatible Different mechanisms; can be combined in longevity protocols.
Molecular Data
Epitalon Humanin
Weight 390.35 Da 2,687 Da
Half-life Not established (short peptide) ~30 minutes (mice), >4 hours (rats)
Chain 4 amino acids 24 amino acids
Type Tetrapeptide Mitochondria-derived peptide
Key Benefits
Epitalon
01 Telomere extension and cellular replicative lifespan extension
02 Enhanced melatonin production
03 Improved immune function
04 Potential lifespan extension (25-33% in animal studies)
05 Systemic anti-aging through cellular rejuvenation
06 Short cycle duration with long-lasting effects
Humanin
01 Potent neuroprotection against Alzheimer's and Parkinson's pathology
02 Extended lifespan in animal models (C. elegans)
03 Improved metabolic healthspan parameters
04 Reduced inflammatory markers
05 Cytoprotective effects across multiple cell types
06 Anti-apoptotic activity
07 Mitochondrial optimization and biogenesis
08 Protection against oxidative stress
Dosing Protocols
Epitalon
100-500mcg per injection / Once daily for 10-20 consecutive days
Standard anti-aging 200-500mcg 1x daily for 10-20 days
Conservative start 100mcg 1x daily for 10-20 days
Russian clinical equivalent 300mcg 1x daily for 10-20 days
Ultra-low dose 50mcg 1x daily for 10-20 days
Humanin
1-5 mg per injection (0.5-2 mg for HNG analog) / 2-3 times weekly for sustained mitochondrial support
Neuroprotection 1-5 mg 2-3x weekly
Longevity/Anti-aging 1-3 mg 2x weekly
HNG analog 0.5-2 mg 2x weekly
Side Effects
Epitalon
Generally well-tolerated with minimal side effects
Mild injection site reactions
Vivid dreams (melatonin-related)
Possible mild digestive upset (oral route)
Humanin
Injection site reactions
Mild fatigue initially
Headache (rare)
Contraindications
Active malignancy (telomerase activation concern)
Chronic sinusitis (nasal route)
Known peptide allergies
Pregnancy or breastfeeding
Active cancer (theoretical concern with anti-apoptotic effects)
Pregnancy or breastfeeding
Hypersensitivity to peptide components
Research Evidence
Epitalon Humanin
Status Well Studied Moderate Research
References 6 studies 4 studies
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.