Epitalon
Synthetic Pineal Tetrapeptide | Telomerase Activator
Epitalon is a synthetic tetrapeptide developed by Russian scientist Vladimir Khavinson with 35+ years of research. It activates telomerase at extremely low concentrations to maintain telomere length, stimulates melatonin production, and modulates gene expression through epigenetic mechanisms.
Mechanism of Action
Activates telomerase at extremely low concentrations (10⁻¹⁷ to 10⁻¹⁵ M) to maintain telomere length, stimulates melatonin production from the pineal gland, and modulates gene expression through epigenetic mechanisms.
Key Benefits
- Telomere extension and cellular replicative lifespan extension
- Enhanced melatonin production
- Improved immune function
- Potential lifespan extension (25-33% in animal studies)
- Systemic anti-aging through cellular rejuvenation
- Short cycle duration with long-lasting effects
AEDGAlanine
Position 1
Glutamic Acid
Position 2
Aspartic Acid
Position 3
Glycine
Position 4
Anti-Aging
- Telomere Extension
Activates telomerase at microgram doses to extend telomeres and cellular replicative lifespan.
- Cellular Rejuvenation
Reverses aging markers and improves mitochondrial function at the cellular level.
- Lifespan Extension
Animal studies show 25-33% lifespan increases using 30-40mcg/kg doses.
Neuroprotection
- Pineal Function Restoration
Restores pineal gland function and circadian melatonin rhythm in elderly.
- Neurogenesis Support
Supports new neuron formation at nanogram concentrations.
- Retinal Protection
90% response rate for retinal degeneration at 5mcg per eye dosing.
Immunity
- Thymus Regeneration
Supports thymus gland regeneration for improved immune function.
- Immune Surveillance
Enhanced immune surveillance and countering of immunosenescence.
Subcutaneous injection is the primary and most researched route. Short cycles of 10-20 days with 4-6 month breaks between cycles.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Standard anti-aging | 200-500mcg | 1x daily for 10-20 days | SubQ |
| Conservative start | 100mcg | 1x daily for 10-20 days | SubQ |
| Russian clinical equivalent | 300mcg | 1x daily for 10-20 days | SubQ |
| Ultra-low dose | 50mcg | 1x daily for 10-20 days | SubQ |
Reconstitution Instructions
- Epitalon lyophilized powder vial (typically 10mg)
- Bacteriostatic water (5mL creates 2mg/mL)
- Insulin syringes (0.3mL for accurate microgram dosing)
- Alcohol swabs
- Sterile work surface
- 1 Clean vial tops with alcohol swabs
- 2 Add 5mL bacteriostatic water to 10mg vial (creates 2mg/mL)
- 3 Inject water slowly at vial side wall
- 4 Gently swirl - do not shake vigorously
- 5 Solution should be clear and colorless
- 6 Refrigerate immediately
- 7 Use 0.3mL insulin syringes for accurate microgram dosing
- 8 Use within 30 days of reconstitution
Different sources recommend different protocols for this peptide. Review each approach and consider your goals, tolerance, and experience level before choosing.
Research-Based Low Dose
TraditionalSource: Published Clinical Studies
"Use doses validated in peer-reviewed human research"
Based on actual human clinical trials, including a study of 75 women using 0.5mg/day sublingually for 20 days. Animal studies typically used 0.1-10mcg/mouse/day. This approach prioritizes evidence-based dosing over anecdotal community protocols.
Key Points
- 0.5-1mg daily (10-20x lower than community protocols)
- Supported by peer-reviewed human clinical data
- 20-day cycle length from clinical trials
- More economical per cycle
- Aligns with research showing microgram-level efficacy
Dosing Schedule
High-Dose Community Protocol
AlternativeSource: Biohacking Communities
"Higher doses for potentially stronger effects"
Widely circulated protocol recommending 5-10mg daily injections. This dosing lacks peer-reviewed human clinical data and may stem from translation errors of Russian research or extrapolation from other peptides. No published studies validate this dose range in humans.
Key Points
- 5-10mg daily (10-20x higher than research protocols)
- No peer-reviewed human data at these doses
- Significantly more expensive per cycle
- Unknown if higher doses provide additional benefit
- May have originated from translation errors
Dosing Schedule
Both work through pineal pathways; may enhance circadian rhythm effects.
Enhanced immunomodulation - commonly combined in Russian protocols.
Different anti-aging pathways; complementary mechanisms.
Different axis activation; no known interactions.
Different regenerative mechanisms.
Both are neuroprotective; monitor for cumulative effects.
Different neurocognitive focus.
Telomerase activation may theoretically affect malignancy; avoid with active cancer.
Subtle energy improvement possible
Better sleep quality, vivid dreams (melatonin effect)
Enhanced morning energy, mood stability
Skin quality improvements, enhanced wound healing
Laboratory markers may show telomere changes
Cumulative anti-aging benefits with repeated cycles
Common Side Effects
- Generally well-tolerated with minimal side effects
- Mild injection site reactions
- Vivid dreams (melatonin-related)
- Possible mild digestive upset (oral route)
Stop Signs - Discontinue if:
- Signs of allergic reaction
- Persistent injection site inflammation
- New or changing moles (monitor skin)
- Cancer diagnosis (discontinue immediately)
- Unusual fatigue or weakness
Contraindications
- Active malignancy (telomerase activation concern)
- Chronic sinusitis (nasal route)
- Known peptide allergies
- Pregnancy or breastfeeding
Good Signs
- White to off-white lyophilized powder
- Clear, colorless solution when reconstituted
- Certificate of analysis available (>98% purity)
- Medical-grade pharmaceutical appearance
- Proper cold-chain shipping
Warning Signs
- Widespread dosing misinformation exists
- Many sources recommend 5-10mg based on translation errors
- Original research demonstrates microgram efficacy
- Verify supplier credentials carefully
Bad Signs
- Yellow or discolored powder (degradation)
- Cloudy solution after mixing (contamination)
- Missing or questionable sourcing documentation
- Telomerase Activation Study(2003)
Human fibroblasts showed extended replicative lifespan (34→44+ passages) at 0.1μM concentration while maintaining telomere length comparable to young cells.
- Russian Clinical Trials(1992-2007)
Long-term observations showed significantly lower all-cause mortality in elderly subjects receiving periodic epithalamin courses with improved cardiovascular and immune parameters.
- Pineal Function Study(2001)
Elderly patients showed restoration of circadian melatonin rhythm and improved sleep/emotional stability using low-dose synthetic treatment.
- Retinal Degeneration Study(2019)
AMD patients achieved 90% positive response with only 5mcg per eye daily dosing.
- Lifespan Extension Study(2003)
Aging mice using 30-40mcg/kg showed 25% lifespan increase and reduced chromosomal aberrations.
- Neurogenesis Study(2020)
Human stem cells showed 1.6-1.8 fold upregulation of neurogenic markers at extremely low concentrations (0.01mcg/mL).
Disclaimer
This information is for educational and research purposes only. Consult a healthcare professional before use.