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Testagen

Moderate Research

KEDG Tetrapeptide | Testicular Bioregulator

Dose 10-20mg daily during cycle
Frequency Daily for 10-20 days, then break
Cycle 10-20 day cycles (typical bioregulator protocol)
Storage Capsules: room temperature. Reconstituted: 2-8°C

Testagen is a Khavinson bioregulator tetrapeptide (KEDG) originally isolated from testicular tissue extracts. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, it promotes testosterone biosynthesis by stimulating Leydig cell activity and improving cellular metabolism in testicular tissue. Research shows it helps restore normal communication within the hypothalamic-pituitary-gonadal (HPG) axis, governing testosterone production and spermatogenesis.

Mechanism of Action

Testagen works through epigenetic regulation, crossing both cell and nuclear membranes to interact directly with DNA of target tissues. It penetrates into cytoplasm, nucleus, and nucleolus of cells, interacting with various cellular components including DNA and RNA. The peptide can discriminate between different nucleotide sequences and recognize cytosine methylation status. It interacts with the anterior pituitary gland and endocrine pathways involved in testosterone and TSH synthesis, restoring HPG axis communication.

Key Benefits

  • Promotes testosterone biosynthesis
  • Stimulates Leydig cell activity
  • Improves testicular cellular metabolism
  • Restores HPG axis communication
  • Supports spermatogenesis
  • Reduces prostatic inflammation
  • Enhances male reproductive balance
  • May normalize testosterone at any age
Molecular Weight
419 Da
Chain Length
4 amino acids
Type
Tetrapeptide bioregulator
Amino Acid Sequence
One-letter: KEDG
H₂N
K 1
O ‖ C
N
E 2
O ‖ C
N
D 3
O ‖ C
N
H
G 4
COOH
Lys
1

Lysine

Position 1

Glu
2

Glutamic Acid

Position 2

Asp
3

Aspartic Acid

Position 3

Gly
4

Glycine

Position 4

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Male Hormone Support

  • Low Testosterone

    Promotes testosterone biosynthesis through Leydig cell stimulation.

  • HPG Axis Restoration

    Restores normal communication within hypothalamic-pituitary-gonadal axis.

  • Age-Related Testosterone Decline

    Addresses declining testosterone through cellular metabolism improvement.

Male Reproductive Health

  • Male Fertility Support

    Supports spermatogenesis and reproductive balance.

  • Testicular Function

    Normalizes testicular function by reducing peptide deficiency.

  • Sexual Function

    May enhance male sexual function through testosterone support.

Prostate Support

  • Prostatic Inflammation

    Research shows reduction in inflammation markers in prostate tissue.

Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles.

GoalDoseFrequencyRoute
Standard protocol10-20 mgDaily for 10-20 daysOral capsules
Maintenance10 mg2-3 cycles yearlyOral capsules
Prostamax

Complementary male reproductive bioregulators; different tissue targets.

synergistic
Gonadorelin

Both support HPG axis function through different mechanisms.

synergistic
Epitalon

Often combined in comprehensive anti-aging Khavinson protocols.

synergistic
HCG

Both support testosterone; different mechanisms.

compatible
During cycle

Gene expression modulation and cellular metabolism changes begin

Post-cycle

Effects persist due to epigenetic changes

Weeks-Months

Testosterone and reproductive function improvements

Long-term

Cumulative benefits with periodic cycles

Common Side Effects

  • Generally well-tolerated
  • Minimal side effects reported

Stop Signs - Discontinue if:

  • Allergic reactions
  • Signs of hormone imbalance

Contraindications

  • Hormone-sensitive cancers (consult oncologist)
  • Known hypersensitivity
  • Female use not established

Good Signs

  • White powder or capsules
  • Clear solution if reconstituted
  • Proper packaging and labeling

Warning Signs

  • Unknown source or purity

Bad Signs

  • Discoloration
  • Unusual odor
  • Damaged packaging
  • Testagen Bioregulator Research on Testosterone and Leydig Cells
    Advances in Gerontology (2018)

    Testagen promotes testosterone biosynthesis by stimulating Leydig cell activity and improving testicular metabolism.

  • Short Peptides and HPG Axis Function
    Bulletin of Experimental Biology and Medicine (2016)

    KEDG peptide helps restore communication within hypothalamic-pituitary-gonadal axis.

  • Epigenetic Effects of Short Peptides
    Neuroendocrinology Letters (2014)

    Testagen penetrates cell nuclei and interacts with DNA, recognizing methylation status.

  • Khavinson Peptide Bioregulators
    Advances in Gerontology (2020)

    Comprehensive review of bioregulator peptides isolated from testicular and other tissue extracts.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.