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Crystagen

Moderate Research

EDP Tripeptide | Thymus Immune Bioregulator

Dose 10-20 mg daily
Frequency Once daily for 10-20 consecutive days
Cycle 10-20 days per cycle
Storage Capsules: room temperature; Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C refrigerated

Crystagen is a Khavinson bioregulator tripeptide (EDP) identified in thymalin with selective action on thymus tissues. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it enhances immune function by stimulating normal lymphocyte proliferation while inhibiting tumor cell growth. Research shows effectiveness in normalizing immunity in 82% of elderly patients (vs 56% control) and reducing respiratory infections in athletes by doubling HSP gene expression.

Mechanism of Action

Crystagen works through epigenetic regulation by influencing gene expression and protein synthesis in immune cells. It regulates the synthesis of heat-shock proteins, cytokines, and affects cell differentiation, proliferation, and apoptosis. The EDP peptide enhances spontaneous proliferative activity of normal lymphocytes while inhibiting proliferation of tumor cells (K-562 erythromyelosis). It activates B-cell immune system and thymic epithelial cells (VTEC2.H/S).

Key Benefits

  • Normalizes immune function in 82% of patients
  • Stimulates normal lymphocyte proliferation
  • Inhibits tumor cell growth (antitumor activity)
  • Doubles HSP gene expression (stress resistance)
  • Reduces respiratory viral infections
  • Activates B-cell immune system
  • Normalizes IL-6 expression
  • Effective after radiation/chemotherapy
Molecular Weight
359 Da
Chain Length
3 amino acids
Type
Tripeptide bioregulator
Amino Acid Sequence
One-letter: EDP
H₂N
E 1
O ‖ C
N
D 2
O ‖ C
N
P 3
COOH
Glu
1

Glutamic Acid

Position 1

Asp
2

Aspartic Acid

Position 2

Pro
3

Proline

Position 3

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Immune Support

  • Immune Dysfunction

    Normalizes immunogram in elderly patients with impaired immunity.

  • Post-Infection Recovery

    Restores immune function after infectious diseases.

  • Radiation/Chemo Recovery

    Helps normalize immunity after radiation and chemotherapy exposure.

Stress Resistance

  • Athletic Immune Support

    Increases stress resistance and reduces respiratory infections in athletes.

  • HSP Expression

    Doubles expression of heat-shock protein gene HSPA1A.

Anti-Tumor

  • Tumor Cell Inhibition

    Inhibits proliferation of K-562 human erythromyelosis tumor cells.

Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles, often repeated 2-3 times per year.

GoalDoseFrequencyRoute
Standard protocol10-20 mgDaily for 10-20 daysOral capsules
Maintenance10 mg2-3 cycles yearlyOral capsules
Athletic support10-20 mgDaily during training cyclesOral capsules
Vilon

Both have immunoprotecting properties; different mechanisms complement each other.

synergistic
Thymalin

Crystagen (EDP) is derived from thymalin; complementary immune effects.

synergistic
Epitalon

Often combined in comprehensive anti-aging Khavinson protocols.

synergistic
Thymogen

Related immune peptides; can be used together.

compatible
During cycle

Immune activation and gene expression modulation begins

Post-cycle

Effects persist due to epigenetic changes

Weeks

Measurable immune function improvements

Long-term

Cumulative benefits with periodic cycles

Common Side Effects

  • Generally well-tolerated
  • Minimal side effects reported

Stop Signs - Discontinue if:

  • Allergic reactions
  • Unusual immune symptoms

Contraindications

  • Active autoimmune flares (consult physician)
  • Known hypersensitivity
  • Pregnancy or breastfeeding

Good Signs

  • White powder or capsules
  • Clear solution if reconstituted
  • Proper packaging and labeling

Warning Signs

  • Unknown source or purity

Bad Signs

  • Discoloration
  • Unusual odor
  • Damaged packaging
  • The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity
    PMC/NCBI (2021)

    EDP (crystagen) identified in thymalin; regulates gene expression, HSP synthesis, cytokines, and cell differentiation.

  • Crystagen in Elderly Patients with Impaired Immunity
    Advances in Gerontology (2018)

    Crystagen normalized immunogram in 82% of patients vs 56% in control group.

  • Peptide Bioregulators in Athletes
    Bulletin of Experimental Biology and Medicine (2019)

    Crystagen doubled HSP gene expression, normalized IL-6, and reduced respiratory infections in athletes.

  • EDP Peptide Effects on Lymphocyte Proliferation
    Cell Technologies in Biology and Medicine (2017)

    EDP enhances normal lymphocyte proliferation while inhibiting K-562 tumor cell proliferation.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.