Crystagen (EDP)

EDP Tripeptide | Thymus Immune Bioregulator

Weight: 359 Da
Half-life: Minutes (short peptide); effects persist via epigenetic changes
Chain: 3 amino acids
4 studies
2021 latest
Moderate Research
Dose 10-20 mg daily
Frequency Once daily for 10-20 consecutive days
Cycle 10-20 days per cycle
Storage Capsules: room temperature; Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C refrigerated

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Crystagen is a Khavinson bioregulator tripeptide (EDP) identified in thymalin with selective action on thymus tissues. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it enhances immune function by stimulating normal lymphocyte proliferation while inhibiting tumor cell growth. Research shows effectiveness in normalizing immunity in 82% of elderly patients (vs 56% control) and reducing respiratory infections in athletes by doubling HSP gene expression.

Mechanism of Action

Crystagen works through epigenetic regulation by influencing gene expression and protein synthesis in immune cells. It regulates the synthesis of heat-shock proteins, cytokines, and affects cell differentiation, proliferation, and apoptosis. The EDP peptide enhances spontaneous proliferative activity of normal lymphocytes while inhibiting proliferation of tumor cells (K-562 erythromyelosis). It activates B-cell immune system and thymic epithelial cells (VTEC2.H/S).

01 Normalizes immune function in 82% of patients
02 Stimulates normal lymphocyte proliferation
03 Inhibits tumor cell growth (antitumor activity)
04 Doubles HSP gene expression (stress resistance)
05 Reduces respiratory viral infections
06 Activates B-cell immune system
07 Normalizes IL-6 expression
08 Effective after radiation/chemotherapy

Molecular Data

Molecular Weight
359 Da
Chain Length
3 amino acids
Type
Tripeptide bioregulator
Amino Acid Sequence
One-letter: EDP
H₂N
E 1
O ‖ C
N
D 2
O ‖ C
N
P 3
COOH
Glu
1

Glutamic Acid

Position 1

Asp
2

Aspartic Acid

Position 2

Pro
3

Proline

Position 3

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Research Indications

Immune Support
Immune Dysfunction effective

Normalizes immunogram in elderly patients with impaired immunity.

Post-Infection Recovery effective

Restores immune function after infectious diseases.

Radiation/Chemo Recovery effective

Helps normalize immunity after radiation and chemotherapy exposure.

Stress Resistance
Athletic Immune Support effective

Increases stress resistance and reduces respiratory infections in athletes.

HSP Expression effective

Doubles expression of heat-shock protein gene HSPA1A.

Anti-Tumor
Tumor Cell Inhibition moderate

Inhibits proliferation of K-562 human erythromyelosis tumor cells.

Dosing Protocols

Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles, often repeated 2-3 times per year.

GoalDoseFrequencyRoute
Standard protocol10-20 mgDaily for 10-20 daysOral capsules
Maintenance10 mg2-3 cycles yearlyOral capsules
Athletic support10-20 mgDaily during training cyclesOral capsules

Interactions

++
Vilon
Both have immunoprotecting properties; different mechanisms complement each other.
synergistic
++
Thymalin
Crystagen (EDP) is derived from thymalin; complementary immune effects.
synergistic
++
Epitalon
Often combined in comprehensive anti-aging Khavinson protocols.
synergistic
+
Thymogen
Related immune peptides; can be used together.
compatible

What to Expect

During cycle
Immune activation and gene expression modulation begins
Post-cycle
Effects persist due to epigenetic changes
Weeks
Measurable immune function improvements
Long-term
Cumulative benefits with periodic cycles

Side Effects & Safety

Common Side Effects

  • Generally well-tolerated
  • Minimal side effects reported

Stop Signs - Discontinue if:

  • Allergic reactions
  • Unusual immune symptoms

Contraindications

  • Active autoimmune flares (consult physician)
  • Known hypersensitivity
  • Pregnancy or breastfeeding

Quality Checklist

Good Signs

  • White powder or capsules
  • Clear solution if reconstituted
  • Proper packaging and labeling

Warning Signs

  • Unknown source or purity

Bad Signs

  • Discoloration
  • Unusual odor
  • Damaged packaging

References

  • The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity
    PMC/NCBI (2021)

    EDP (crystagen) identified in thymalin; regulates gene expression, HSP synthesis, cytokines, and cell differentiation.

  • Crystagen in Elderly Patients with Impaired Immunity
    Advances in Gerontology (2018)

    Crystagen normalized immunogram in 82% of patients vs 56% in control group.

  • Peptide Bioregulators in Athletes
    Bulletin of Experimental Biology and Medicine (2019)

    Crystagen doubled HSP gene expression, normalized IL-6, and reduced respiratory infections in athletes.

  • EDP Peptide Effects on Lymphocyte Proliferation
    Cell Technologies in Biology and Medicine (2017)

    EDP enhances normal lymphocyte proliferation while inhibiting K-562 tumor cell proliferation.

Related Peptides

Vilon synergistic

Both have immunoprotecting properties; different mechanisms complement each other.

Thymalin synergistic

Crystagen (EDP) is derived from thymalin; complementary immune effects.

Epitalon synergistic

Often combined in comprehensive anti-aging Khavinson protocols.

Thymogen compatible

Related immune peptides; can be used together.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.