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Thymalin

Well Studied

Thymic Peptide Bioregulator | Immune Modulator

Dose 10mg per injection
Frequency Daily for 5-10 days, then break
Cycle 5-10 day cycles (short bioregulator protocol)
Storage Reconstituted: 2-8°C refrigerated

Thymalin is a natural peptide bioregulator derived from calf thymus gland, developed in the Soviet Union in the 1970s. It contains a mixture of thymic peptides that support immune restoration, anti-aging, and tissue regeneration. Research spanning decades has shown significant geroprotective effects, with studies demonstrating up to 2-fold reduction in mortality rates and 4-fold reduction when combined with Epithalamin.

Mechanism of Action

Thymalin's immunoprotective action stems from short peptides (KE, EW, EDP) that specifically bind to double-stranded DNA and histone proteins to regulate gene expression. It stimulates differentiation and activity of T-lymphocytes, especially CD4+ and CD8+ cells, promotes cytokine regulation, enhances antigen response, and stimulates stem cell differentiation. It also affects gerontogene activity and immune system protein synthesis.

Key Benefits

  • Potent immune system restoration and modulation
  • Significant geroprotective (anti-aging) effects
  • Reduced mortality rate in clinical studies (2.0-2.1 fold)
  • Normalized cardiovascular, endocrine, and nervous system function
  • Reduced acute respiratory disease incidence (2.0-2.4 fold)
  • Enhanced T-lymphocyte differentiation (CD4+, CD8+)
  • Antitumor effects in animal studies
  • Safe for elderly populations with no side effects
Molecular Weight
Variable (peptide complex)
Type
Polypeptide mixture

Immune Support

  • Immune Restoration

    Stimulates T-lymphocyte differentiation and activity for comprehensive immune system restoration.

  • Lymphopenia Recovery

    Accelerates recovery of lymphocyte populations including CD4+, CD3+HLA-DR+, B-cells, and NK-cells.

  • Respiratory Illness Prevention

    2.0-2.4 fold reduction in acute respiratory disease incidence in elderly patients.

Longevity

  • Mortality Reduction

    Clinical studies showed 2.0-2.1 fold mortality reduction over 6-8 years in treated elderly.

  • Geroprotection

    Normalizes basic body functions and improves cardiovascular, endocrine, immune, and nervous systems.

  • Combined Protocol

    When combined with Epithalamin for 6 years, mortality decreased 4.1 times vs control.

Therapeutic Applications

  • COVID-19 Support

    Faster reversal of lymphopenia and immune marker recovery in severe COVID-19 patients.

  • Antitumor Effects

    Tumor growth arrest and regression observed in over half of animals in sarcoma studies.

  • Thymus Normalization

    Normalizes thymus function during aging process.

Administered via intramuscular or subcutaneous injection in short 5-10 day cycles. Often combined with other bioregulators like Epitalon or Vilon for enhanced systemic effects. Practically no side effects, safe for elderly populations.

GoalDoseFrequencyRoute
Immune restoration10 mgDailyIM or SubQ
Standard cycle10 mgDaily for 5-10 daysIM or SubQ
Maintenance10 mg1-2x yearly cyclesIM or SubQ
With Epithalamin10 mg eachAnnual cyclesIM or SubQ

Reconstitution Instructions

Materials Needed:
  • Bacteriostatic water or sterile water
  • Insulin syringes (1 mL)
  • Alcohol swabs
  • Peptide vial
  • Sterile work surface
  1. 1 Clean work area and hands thoroughly
  2. 2 Calculate required water volume
  3. 3 Draw water into syringe
  4. 4 Inject slowly down vial side
  5. 5 Gently swirl until dissolved (never shake)
  6. 6 Store in refrigerator
Epitalon

Combined use showed 4.1-fold mortality reduction vs 2.0-fold with Thymalin alone.

synergistic
Vilon

Often used together for enhanced systemic recovery and immune support.

synergistic
Thymosin Alpha-1

Similar thymic origin; different mechanisms can complement each other.

compatible
BPC-157

No known negative interactions; different mechanisms.

compatible
Days 1-5

Initial immune modulation begins

Days 5-10

T-cell activation and differentiation enhanced

Week 2-4

Improved immune markers on blood tests

Month 1-3

Reduced illness frequency

Long-term (years)

Geroprotective benefits with annual cycles

Common Side Effects

  • Injection site reactions (mild)
  • Practically no side effects reported

Stop Signs - Discontinue if:

  • Signs of allergic reaction
  • Unusual immune responses

Contraindications

  • Autoimmune diseases (use with caution)
  • Organ transplant recipients (immunosuppression needed)
  • Pregnancy or breastfeeding
  • Known hypersensitivity

Good Signs

  • White to off-white lyophilized powder
  • Clear solution after reconstitution
  • Intact vacuum seal

Warning Signs

  • Slight clumping that dissolves easily

Bad Signs

  • Discolored powder
  • Cloudy or particulate solution
  • Broken seal
  • The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity
    International Journal of Molecular Sciences (2021)

    Detailed molecular mechanisms of Thymalin's immunoprotective action through peptides KE, EW, EDP binding to DNA and histones.

  • Peptides of Pineal Gland and Thymus Prolong Human Life
    Neuroendocrinology Letters (2003)

    6-8 year study showed 2.0-2.1 fold mortality reduction with Thymalin; 4.1-fold when combined with Epithalamin.

  • Peptide Drug Thymalin Regulates Immune Status in Severe COVID-19 Older Patients
    Advances in Gerontology (2021)

    Faster lymphopenia reversal and improved recovery of CD4+, CD3+HLA-DR+, B-cells, and NK-cells in COVID-19.

  • Effect of Thymalin on Tumor and Thymus in Activation Therapy
    Bulletin of Experimental Biology and Medicine (2018)

    Antitumor effects with tumor growth arrest in >50% of animals; growth suppressed by 78% in others.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.