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NA-Selank Amidate

Moderate Research

N-Acetyl Selank Amidate | Enhanced Anxiolytic Nootropic

Dose 200-500mcg per administration
Frequency 1-2x daily for 14-20 days
Cycle 2-3 weeks (14-20 days)
Storage Refrigerate at 2-8°C
Accumulation Plotter

NA-Selank Amidate is an enhanced version of Selank, the anxiolytic nootropic peptide developed at Russia's Institute of Molecular Genetics. The N-acetyl group improves blood-brain barrier penetration and creates more stable metabolites, while the C-terminal amidation further enhances metabolic stability and receptor binding. Unlike benzodiazepines, it provides anxiety relief without sedation, dependency, or cognitive impairment.

Mechanism of Action

NA-Selank Amidate modulates multiple neurotransmitter systems including GABA, dopamine, and serotonin, while regulating brain-derived neurotrophic factor (BDNF). It allosterically modulates GABAA receptors without causing the sedation or dependency of benzodiazepines. The peptide activates serotonin metabolism in the hypothalamus and brainstem, and increases BDNF levels to promote neuronal growth and differentiation.

Key Benefits

  • Pronounced anxiolytic effects without sedation
  • Enhanced blood-brain barrier penetration (vs standard Selank)
  • Improved metabolic stability and longer half-life
  • Nootropic effects with enhanced memory and learning
  • Increased BDNF levels for neuroplasticity
  • No dependency or withdrawal effects
  • Immune-modulating properties
  • Effects persist after treatment cessation
Molecular Weight
864 Da
Chain Length
7 amino acids + modifications
Type
Modified heptapeptide
Amino Acid Sequence
One-letter: ?TKPRPGP?
H₂N
H
? 1
O ‖ C
N
T 2
O ‖ C
N
K 3
O ‖ C
N
P 4
O ‖ C
N
R 5
O ‖ C
N
P 6
O ‖ C
N
H
G 7
O ‖ C
N
P 8
O ‖ C
N
H
? 9
COOH
Ac
1

Ac

Position 1

Thr
2

Threonine

Position 2

Lys
3

Lysine

Position 3

Pro
4

Proline

Position 4

Arg
5

Arginine

Position 5

Pro
6

Proline

Position 6

Gly
7

Glycine

Position 7

Pro
8

Proline

Position 8

NH2
9

NH2

Position 9

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Anxiety & Mood

  • Generalized Anxiety

    Standard Selank approved in Russia for GAD; NA-Selank Amidate offers enhanced delivery.

  • Stress Response

    Modulates stress response through GABA and serotonin systems without sedation.

  • Mood Enhancement

    Improves mood through serotonin metabolism activation.

Cognitive Enhancement

  • Memory Enhancement

    Increases memory trace stability for up to 30 days in animal studies.

  • Learning

    BDNF elevation supports learning and neuroplasticity.

  • Neuroprotection

    BDNF increase reduces effects of neurological injury.

Immune Support

  • Immune Modulation

    Based on tuftsin structure, retains immunomodulatory properties.

Intranasal spray is the preferred delivery method, providing direct access to the brain while bypassing first-pass metabolism. The N-acetyl and amide modifications enhance absorption and stability.

GoalDoseFrequencyRoute
Anxiety relief250-500 mcg1-2x dailyIntranasal
Cognitive enhancement200-400 mcg1-2x dailyIntranasal
Standard protocol300 mcg1-2x daily for 14 daysIntranasal
Semax

Often combined for comprehensive cognitive enhancement and mood support.

synergistic
NA-Semax Amidate

Enhanced versions combine well for cognitive and anxiolytic effects.

synergistic
Dihexa

Different nootropic mechanisms; can be combined.

compatible
BPC-157

No known negative interactions.

compatible
Minutes to hours

Anxiolytic effects begin; reduced stress response

Days 1-3

Nootropic effects become noticeable

Week 1-2

Full anxiolytic and cognitive benefits

Post-treatment

Benefits persist for approximately 1 week after 14-day course

Common Side Effects

  • Generally well-tolerated
  • Mild nasal irritation (intranasal)
  • Fatigue (rare)

Stop Signs - Discontinue if:

  • Allergic reactions
  • Paradoxical anxiety increase
  • Unusual mood changes

Contraindications

  • Pregnancy or breastfeeding
  • Known hypersensitivity to Selank or tuftsin
  • Severe psychiatric conditions (consult professional)

Good Signs

  • White to off-white lyophilized powder
  • Clear solution after reconstitution
  • Intact vacuum seal

Warning Signs

  • Slight clumping that dissolves easily

Bad Signs

  • Discolored powder
  • Cloudy or particulate solution
  • Unusual odor
  • Selank Administration Affects Expression of Genes in GABAergic Neurotransmission
    Frontiers in Pharmacology (2016)

    Selank modulates GABAA receptor activity, contributing to anxiolytic effects without benzodiazepine-like side effects.

  • Selank Clinical Trial in Anxiety Disorders
    Zhurnal Nevrologii i Psikhiatrii (2008)

    14 days of intranasal Selank produced pronounced anxiolytic and mild nootropic effects; benefits persisted 1 week post-treatment.

  • Selank and Serotonin Metabolism
    Bulletin of Experimental Biology and Medicine (2006)

    Single Selank injection activated serotonin metabolism and increased memory trace stability for up to 30 days.

  • Selank and BDNF Expression
    Regulatory Peptides (2009)

    Selank administration increases BDNF levels, supporting neuronal growth and memory enhancement.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.