DSIP
Delta Sleep-Inducing Peptide | Sleep & Stress Modulator
DSIP is a naturally occurring nonapeptide discovered in 1974 in rabbit brain. Originally isolated for sleep-promoting properties, it has diverse neuromodulatory effects including stress reduction, pain modulation, and endocrine regulation without traditional sedative effects.
Mechanism of Action
Modulates multiple neurotransmitter systems including GABA enhancement, NMDA receptor interaction, and endogenous opioid system modulation. Also regulates hypothalamic-pituitary-adrenal axis for stress response.
Key Benefits
- Enhanced sleep quality through slow-wave sleep promotion
- Stress reduction via cortisol modulation
- Potential pain relief
- Mood stabilization without traditional sedative effects
- No tolerance or dependence reported
- Short cycle duration (5-10 days)
WAGGDASGETryptophan
Position 1
Alanine
Position 2
Glycine
Position 3
Glycine
Position 4
Aspartic Acid
Position 5
Alanine
Position 6
Serine
Position 7
Glycine
Position 8
Glutamic Acid
Position 9
Sleep
- Deep Sleep Enhancement
Promotes delta wave sleep, the most restorative sleep phase for physical recovery.
- Sleep Efficiency
Reduces sleep latency and nocturnal awakenings without morning grogginess.
- Natural Sleep Architecture
Supports natural sleep cycles rather than forcing sedation like traditional sleep aids.
Mood
- Stress Response Modulation
Helps regulate cortisol and stress response through HPA axis modulation.
- Mood Stabilization
Supports emotional balance without sedation.
- Anxiety Reduction
May help reduce anxiety through neuromodulatory effects.
Pain & Recovery
- Pain Modulation
Significantly reduced pain levels in 6 of 7 patients with chronic pain conditions.
- Withdrawal Support
Helps manage withdrawal symptoms in alcohol and opioid-dependent patients.
- Athletic Recovery
Supports post-training recovery through enhanced sleep quality.
Subcutaneous injection is the standard route. Best taken 30-60 minutes before bedtime. Some prefer earlier evening dosing for gradual onset.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Sleep enhancement | 100-200mcg | Once nightly | SubQ |
| Chronic pain support | 250-300mcg | Daily | SubQ or IV |
| Stress management | 150mcg | Evening | SubQ |
| Withdrawal support | 200-300mcg | Twice daily | IV preferred |
| Athletic recovery | 100-150mcg | Post-training | SubQ |
Reconstitution Instructions
- DSIP peptide vial (1-5mg typical)
- Bacteriostatic water (1-2mL)
- Insulin syringes (0.3-0.5mL)
- Alcohol swabs
- Sterile needle for mixing
- 1 Clean vial tops with alcohol swab and let dry completely
- 2 For 1mg vial, add 1mL bacteriostatic water (creates 1000mcg/mL)
- 3 Inject water slowly down vial side to prevent foaming
- 4 Gently roll between palms - do not shake
- 5 Solution should be clear and colorless
- 6 For 100mcg dose, draw 0.1mL (10 units on insulin syringe)
- 7 Store reconstituted peptide in refrigerator immediately
Both regulate sleep-wake cycles; complementary benefits.
DSIP enhances GABA - watch for excessive sedation.
Can combine for comprehensive stress management.
Complementary anxiolytic effects.
Different mechanisms; can optimize 24-hour function.
May modulate opioid receptors; requires professional supervision.
No direct interaction; DSIP may support natural GH release during sleep.
Both support circadian regulation and sleep quality.
Noticeable sleep pressure and easier sleep onset
Deeper sleep, fewer awakenings, vivid dreams possible
Improved morning refreshment, stable daytime energy
Cumulative stress reduction, mood improvements
Benefits may persist 1-2 weeks after stopping
Common Side Effects
- Generally well-tolerated with minimal side effects
- Mild drowsiness or dizziness initially (some users)
- Occasional headaches in sensitive individuals
- No tolerance or dependence reported in studies
Stop Signs - Discontinue if:
- Excessive daytime sedation
- Paradoxical insomnia or agitation
- Persistent headaches
- Any allergic reactions
- Mood changes or depression
- Unusual dreams causing distress
Contraindications
- Avoid driving until effects are known
- Pregnancy or breastfeeding
Good Signs
- White lyophilized powder before reconstitution
- Clear and colorless solution when properly mixed
- Reputable source with third-party testing
Warning Signs
- Short stability period - use within 14 days when reconstituted
- Protect from light exposure and temperature fluctuations
- Limited nasal formulation stability (use within 10 days)
Bad Signs
- Yellow or cloudy solution indicates degradation or contamination
- Discolored powder
- Chronic Insomnia Double-Blind Study(1991)
15-30 nmol for 6 consecutive nights improved objective sleep quality with higher sleep efficiency and shorter sleep latency compared to placebo.
- Chronic Pain Pilot Study(1984)
25 nmol IV for 10 days significantly reduced pain levels in 6 of 7 patients with chronic pain conditions including migraine and tinnitus.
- Alcohol and Opioid Withdrawal Study(1984)
DSIP administration helped manage withdrawal symptoms in both alcohol and opioid-dependent patients over 5-10 days.
- Sleep Pressure Induction Study(1983)
Single 25 nmol/kg IV dose showed 59% increase in total sleep time within 130 minutes; improved subsequent night sleep efficiency.
- Stroke Recovery in Rats(2021)
120mcg/kg nasal for 7 days enhanced motor recovery without significantly reducing infarct size.
Disclaimer
This information is for educational and research purposes only. Consult a healthcare professional before use.