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Pinealon

Well Studied

Synthetic Tripeptide | Neuroprotection & Cognitive Enhancement

Dose Injectable: 5mg daily or 100-300mcg daily; Oral: 0.2mg twice daily
Frequency Injectable: daily for 20 days; Oral: morning and afternoon on empty stomach
Cycle 20 days per cycle
Storage Refrigerate at 2-8°C, use within 30 days after reconstitution

Developed in Russia, Pinealon demonstrates unique DNA-interaction for neuroprotection and cognitive enhancement. Benefits traumatic brain injury recovery and age-related cognitive decline with excellent safety profile.

Mechanism of Action

Penetrates nuclear membranes to directly interact with DNA, modulates gene expression via histone H1.3 binding and MAPK/ERK pathway activation.

Key Benefits

  • Direct DNA interaction
  • Neuroprotection
  • Cognitive enhancement
  • Excellent safety profile
  • 40+ years of clinical use in Russia
Molecular Weight
418.4 Da
Chain Length
3 amino acids
Type
Tripeptide
Amino Acid Sequence
One-letter: ED?
H₂N
E 1
O ‖ C
N
D 2
O ‖ C
N
H
? 3
COOH
Glu
1

Glutamic Acid

Position 1

Asp
2

Aspartic Acid

Position 2

Arg
3

Arg (EDR)

Position 3

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Neuroprotection

  • Traumatic Brain Injury

    Clinical protocol of 5mg daily showed significant cognitive improvements in 72-patient study.

  • Direct CNS Delivery

    Subcutaneous administration allows systemic circulation to brain tissue for neuroprotective effects.

  • Cellular Protection

    Caspase-3 suppression, ROS reduction, and excitotoxicity protection.

Cognitive

  • Memory Enhancement

    Enhanced neurotransmitter function with 1.9x serotonin increase in cell cultures.

  • NMDA Receptor Expression

    100 ng/kg optimal dose improved spatial learning in hippocampus.

Anti-Aging

  • Cellular Senescence Reduction

    Irisin expression increases linked to telomere protection and mitochondrial enhancement.

  • Biological Age Markers

    32-patient study showed significant improvements in aging indicators over 20-30 days.

Highest bioavailability, direct systemic delivery, established clinical protocols.

GoalDoseFrequencyRoute
Neuroprotection5mg dailyOnce dailySubQ
Cognitive Enhancement100-300mcgDaily or every other daySubQ
Anti-aging5mg20 days, 2-3x yearlySubQ

Reconstitution Instructions

Materials Needed:
  • Lyophilized Pinealon powder
  • Bacteriostatic water for injection
  • Insulin syringes (30-31 gauge)
  • Alcohol swabs
  1. 1 Remove powder and water from refrigeration
  2. 2 Clean vial tops with alcohol swabs; allow to dry
  3. 3 Draw bacteriostatic water into syringe
  4. 4 Inject water slowly down vial side to avoid foam
  5. 5 Gently swirl until completely dissolved
  6. 6 Store at 2-8°C
  7. 7 Use within 30 days
Epitalon

Enhanced neuroprotection through complementary telomerase activation pathways.

synergistic
Cortexin

Synergistic cognitive recovery in stroke patients through brain region targeting.

synergistic
Thymalin

Safe combination supporting neural-immune axis optimization.

compatible
Melatonin

Monitor sleep patterns; Pinealon stimulates endogenous serotonin production.

monitor
BPC-157

Different mechanisms with no known interactions.

compatible
NAD+

Complementary anti-aging mechanisms.

compatible
Week 1-2

Improved mental clarity and focus

Week 2-3

Enhanced cognitive processing and memory

Week 3-4

Peak neuroprotective and anti-aging benefits

Common Side Effects

  • Minimal injection site reactions
  • Mild gastrointestinal adjustment
  • Occasional headache
  • Fatigue

Stop Signs - Discontinue if:

  • Severe headaches or mood changes
  • Persistent injection site reactions
  • Signs of infection at injection site
  • Unusual neurological symptoms
  • Allergic reactions

Contraindications

  • Pregnancy
  • Lactation

Good Signs

  • White crystalline powder; proper freeze-drying indicated
  • Clear reconstituted solution; no particles or cloudiness
  • Pharmaceutical packaging with batch numbers from reputable sources

Warning Signs

  • Ensure distinction between research (lab only) and pharmaceutical (human use) grade

Bad Signs

  • Discolored powder (yellow or brown) indicates degradation from heat or moisture
  • Cloudy solution indicates contamination
  • Human Clinical Trial - Post-Traumatic Cerebrasthenia
    (2015)

    72 patients aged 30-74; 0.2mg twice daily; 20-30 days. Improved memory, reduced headache severity, and enhanced emotional stability compared to controls.

  • Aging Study - Polymorbidity Patients
    (2015)

    32 patients aged 41-83; variable dosing; 30 days. Significant improvements in biological aging biomarkers with anabolic effects.

  • Diabetic Rat Model - Spatial Learning
    (2020)

    100 ng/kg optimal dose; 14 days. Enhanced NMDA receptor expression in hippocampus with neuroplasticity improvements.

  • 5xFAD Alzheimer's Mouse Model
    (2021)

    400 μg/kg IP daily; 28 days. Prevention of dendritic spine loss through MAPK/ERK pathway modulation.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.