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Adamax

Emerging

Next-Generation Semax Derivative | Nootropic Neuropeptide

Dose 200-300mcg
Frequency Once daily, or twice for enhanced neuroprotection
Cycle 2-4 weeks
Storage Lyophilized: room temp or freezer. Reconstituted: 2-8°C for 14-30 days
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Synthetic nootropic peptide with N-terminal acetylation and C-terminal adamantane modification for superior stability and blood-brain barrier penetration, researched for cognitive enhancement, neuroprotection, and neuroplasticity.

Mechanism of Action

Crosses BBB via enhanced lipophilicity from adamantane; upregulates BDNF and TrkB receptor sensitivity; modulates dopamine, norepinephrine, and serotonin; stabilizes microtubules via ADNP-derived mechanisms; provides antioxidant and anti-inflammatory neuroprotection.

Key Benefits

  • Enhanced cognitive function and mental clarity
  • Improved focus and complex task handling
  • Neuroprotection against oxidative stress
  • Neuroplasticity support through BDNF upregulation
  • Potential mood enhancement
  • Stress resilience through HPA axis modulation
Molecular Weight
1,032.24 Da
Chain Length
9 amino acids (with modifications)
Type
Modified heptapeptide derivative
Amino Acid Sequence
One-letter: ?MEHFPGP??
H₂N
H
? 1
O ‖ C
N
M 2
O ‖ C
N
E 3
O ‖ C
N
H 4
O ‖ C
N
F 5
O ‖ C
N
P 6
O ‖ C
N
H
G 7
O ‖ C
N
P 8
O ‖ C
N
H
? 9
O ‖ C
N
H
? 10
COOH
Ac
1

Ac

Position 1

Met
2

Methionine

Position 2

Glu
3

Glutamic Acid

Position 3

His
4

Histidine

Position 4

Phe
5

Phenylalanine

Position 5

Pro
6

Proline

Position 6

Gly
7

Glycine

Position 7

Pro
8

Proline

Position 8

AGl
9

AGly

Position 9

NH2
10

NH2

Position 10

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Cognitive

  • Cognitive Enhancement

    Preliminary research suggests improvements in focus, mental clarity, memory consolidation, and complex task handling.

  • Neuroplasticity Support

    BDNF upregulation and TrkB enhancement promote new neural connections and synaptic plasticity for long-term improvements.

  • Learning and Memory

    May enhance memory formation, information retention, and learning efficiency through hippocampal BDNF-TrkB pathway activation.

Neuroprotective

  • Stroke Recovery

    Preliminary observations indicate improved neurological outcomes through oxidative stress reduction and neuronal repair.

  • Oxidative Stress Protection

    Demonstrates antioxidant properties protecting against oxidative damage and inflammation-induced neuronal injury.

  • Neuronal Maintenance

    Supports neuronal survival and growth through BDNF enhancement and microtubule stabilization.

Mood

  • Mood Enhancement

    Influences serotonin and dopamine to elevate mood and reduce depressive symptoms through neurotransmitter modulation.

  • Anxiety Reduction

    Anecdotal reports indicate reduced overwhelm and anxiety through balanced neurotransmitter activity.

  • Stress Resilience

    HPA axis modulation may improve stress response and emotional well-being.

Enhanced cognitive function and neuroprotection through direct systemic delivery with superior bioavailability.

GoalDoseFrequencyRoute
Cognitive Enhancement200-300mcg1x dailySubQ
Neuroprotection300mcg1-2x dailySubQ
Mood Support200mcg1x daily (morning)SubQ
Initial Trial100-200mcg1x dailySubQ

Reconstitution Instructions

Materials Needed:
  • Bacteriostatic water (BAC)
  • Insulin syringes (0.5-1mL)
  • Alcohol swabs
  • Peptide vial
  • Sterile work surface
  1. 1 Clean work area and hands thoroughly with alcohol
  2. 2 Calculate required BAC water volume using calculator
  3. 3 Draw calculated BAC water into syringe
  4. 4 Inject slowly down vial side (not directly onto powder)
  5. 5 Gently swirl until completely dissolved (never shake vigorously)
  6. 6 Store reconstituted solution in refrigerator at 2-8°C
  7. 7 Use within 14-30 days for optimal potency
Semax

Adamax is an enhanced derivative with improved stability and bioavailability.

compatible
P21

Adamax incorporates adamantyl portion from P21; may complement cognitive benefits.

synergistic
BPC-157

Different mechanisms—Adamax targets neurological function; BPC-157 focuses on tissue repair.

compatible
Noopept

Both enhance cognition through different mechanisms but share BDNF upregulation; start lower doses and monitor for overstimulation.

monitor
Hours 1-4

Potential acute cognitive enhancement and improved focus

Week 1-2

Enhanced mental clarity, reduced anxiety, improved mood

Week 2-4

Neuroplasticity benefits, sustained cognitive improvements

Week 4+

Maximum neuroprotective and structural brain benefits

Common Side Effects

  • Headaches (particularly at higher doses)
  • Insomnia or sleep disruption
  • Anxiety or overstimulation
  • Cardiovascular effects (elevated blood pressure, palpitations)

Stop Signs - Discontinue if:

  • Persistent or severe headaches
  • Chest pain, heart palpitations, or significant blood pressure increases
  • Severe anxiety, insomnia, or mood disturbances
  • Unusual neurological symptoms or mental status changes
  • Persistent injection site reactions or infection signs
  • Gastrointestinal distress (nausea, vomiting, diarrhea)

Contraindications

  • Pregnancy and breastfeeding
  • Cardiovascular conditions (without medical supervision)
  • Severe anxiety disorders
  • Uncontrolled hypertension

Good Signs

  • White, fluffy powder indicating proper freeze-drying
  • Clear solution after reconstitution with no particles or cloudiness
  • Proper labeling with peptide name, batch number, manufacturing date

Warning Signs

  • Slight compaction from shipping acceptable if powder dissolves completely

Bad Signs

  • Discoloration or yellowing indicates oxidation or degradation
  • Persistent cloudiness or particles indicate degradation or contamination
  • Semax Cognitive Enhancement in Fatigued Volunteers (Parent Compound)
    (N/A)

    Single intranasal administration (16 mcg/kg) resulted in 71% accuracy on memory tests versus 41% in controls, with effects lasting 24 hours.

  • Semax in Stroke Recovery - BDNF Elevation (Parent Compound)
    (N/A)

    110 patients, 6000 mcg/day intranasal showed increased plasma BDNF levels, improved motor performance, enhanced functional independence.

  • Adamax Stroke Recovery Preliminary Reports
    (N/A)

    Patients treated shortly after stroke showed better neurological outcomes through oxidative stress reduction.

  • BDNF and TrkB Receptor Upregulation Studies
    (N/A)

    Adamax increases BDNF levels and enhances TrkB receptor sensitivity in hippocampus.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.