NA Semax Amidate (N-Acetyl Semax Amidate)

Enhanced Nootropic Peptide | Cognitive Enhancement & Neuroprotection

Weight: 1,007.16 Da
Half-life: 2-10 hours
Chain: 7 amino acids
5 studies
2018 latest
3 recent
Well Studied
Dose 600-1200mcg per administration
Frequency 1-2x daily for 10-30 days
Cycle 10-30 days
Storage Refrigerate at 2-8°C
Accumulation Plotter

Community Research

Join others researching NA Semax Amidate — share findings, ask questions, and learn from real experiences

View Results Aggregated community findings
Discussion Questions & experiences
Submit Your Findings Contribute your research data

Enhanced and stabilized version of Russian nootropic Semax with superior stability, extended half-life, and enhanced bioavailability through acetylation and amidation modifications.

Mechanism of Action

Bypasses blood-brain barrier via olfactory nerves with direct brain access; enhances BDNF upregulation and hippocampal plasticity.

01 Direct brain access via olfactory nerves
02 Rapid onset (15-30 minutes)
03 Proven cognitive efficacy
04 Extended half-life vs standard Semax
05 Enhanced BDNF upregulation

Molecular Data

Molecular Weight
1,007.16 Da
Chain Length
7 amino acids
Type
Modified ACTH analog
Amino Acid Sequence
One-letter: NAMEHFPGP?
H₂N
N 1
O ‖ C
N
A 2
O ‖ C
N
M 3
O ‖ C
N
E 4
O ‖ C
N
H 5
O ‖ C
N
F 6
O ‖ C
N
P 7
O ‖ C
N
H
G 8
O ‖ C
N
P 9
O ‖ C
N
H
? 10
COOH
Asn
1

Asparagine

Position 1

Ala
2

Alanine

Position 2

Met
3

Methionine

Position 3

Glu
4

Glutamic Acid

Position 4

His
5

Histidine

Position 5

Phe
6

Phenylalanine

Position 6

Pro
7

Proline

Position 7

Gly
8

Glycine

Position 8

Pro
9

Proline

Position 9

NH₂
10

NH₂

Position 10

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified
Peak 0.0 mcg
Trough 0.0 mcg
SS Peak 0.0 mcg
SS Trough 0.0 mcg

Research Indications

Cognitive
Enhanced Focus and Attention most effective

Rapid improvement in sustained attention, working memory, and mental clarity within 15-30 minutes.

Memory Formation most effective

Enhances both short-term and long-term memory consolidation through BDNF upregulation.

Mental Fatigue Resistance most effective

Significant improvement in cognitive performance during mental fatigue, with lasting effects.

Neuroprotection
Stroke Recovery Support effective

Accelerates functional recovery through enhanced neuroplasticity and BDNF elevation.

Oxidative Stress Protection effective

Protects against neural oxidative damage and supports cellular repair mechanisms.

Neurotrophic Factor Enhancement effective

Rapidly increases BDNF and TrkB receptor expression, supporting neuronal survival.

Memory
Episodic Memory Enhancement effective

Improves episodic memory formation and recall through default mode network optimization.

Learning Acceleration moderate

Enhances acquisition of new information through improved synaptic plasticity.

Dosing Protocols

Direct brain access via olfactory nerves with rapid onset and proven efficacy.

GoalDoseFrequencyRoute
Cognitive enhancement600mcg1x dailyIntranasal spray
Mental fatigue resistance800mcg1x dailyIntranasal spray
Memory enhancement600mcg2x dailyIntranasal spray
Neuroprotection1200mcg1x dailyIntranasal spray

Reconstitution Instructions

Materials Needed:
  • NA Semax Amidate lyophilized powder
  • Sterile saline solution (0.9% NaCl)
  • Nasal spray bottles (sterile)
  • Precision scale for dosing
  1. 1 Calculate desired concentration (0.1% or 0.3%)
  2. 2 Add sterile saline slowly to powder
  3. 3 Swirl gently until dissolved
  4. 4 Transfer to nasal spray bottle
  5. 5 Label and refrigerate

Interactions

++
NA Selank Amidate
Excellent combination providing comprehensive cognitive support with nootropic and anxiolytic benefits.
synergistic
+
BPC-157
Different mechanisms with complementary neuroprotective benefits.
compatible
+
Lion's Mane
Both enhance BDNF and neuroplasticity; may provide additive cognitive benefits.
compatible
~
Modafinil
Both affect focus; combination may cause overstimulation in some individuals.
monitor
~
Blood Pressure Medications
Monitor blood pressure as Semax may affect vascular function.
monitor
!
MAO Inhibitors
Semax affects neurotransmitter systems; combination may cause unpredictable effects.
avoid

What to Expect

15-30 minutes
Initial cognitive clarity and focus improvement
1-2 hours
Peak cognitive enhancement and mental alertness
2-6 hours
Sustained attention and memory benefits
6-12 hours
Gradual return to baseline with lasting effects

Side Effects & Safety

Common Side Effects

  • Mild nasal irritation (intranasal)
  • Slight headache initially

Stop Signs - Discontinue if:

  • Persistent nasal irritation, burning, or bleeding
  • Severe headaches or dizziness after administration
  • Unusual mood changes, anxiety, or agitation
  • Sleep disturbances or insomnia
  • Any allergic reactions (swelling, rash, difficulty breathing)
  • Significant changes in blood pressure or heart rate

Contraindications

  • Not recommended during pregnancy
  • Active nasal congestion or sinus infection
  • Individuals on neurotransmitter-affecting medications without consultation

Quality Checklist

Good Signs

  • White, fluffy powder that reconstitutes clearly
  • Clear solution with no particles or cloudiness
  • Third-party purity testing certificates showing >98% purity

Warning Signs

  • Ensure proper cold chain maintained during shipping

Bad Signs

  • Discolored powder (yellow or brown indicates degradation)
  • Cloudiness after reconstitution indicates contamination

References

  • A Nootropic Adrenocorticotropin Analog 4-10 Semax: 15 Years Experience in Its Design and Study (Parent Compound)
    Ashmarin IP, Nezavibatko VN, Levitskaya NG, et al.
    Zhurnal Vysshei Nervnoi Deiatelnosti imeni I.P. Pavlova (1997)

    Foundational Semax review: intranasal doses of 0.015-0.050 mg/kg stimulate operative memory and attention for 20-24 hours. NA-Semax-Amidate modifications extend half-life and enhance bioavailability.

  • Effects of Semax on the Default Mode Network of the Brain (Parent Compound)
    Dolgorukova AM, Klyushnik TP, Gusev EI, et al.
    Bulletin of Experimental Biology and Medicine (2018)

    24 healthy volunteers; resting-state fMRI showed increased default mode network volume in medial frontal cortex after intranasal 1% Semax vs placebo, enhancing episodic memory.

  • The Efficacy of Semax in the Treatment of Patients at Different Stages of Ischemic Stroke (Parent Compound)
    Gusev EI, Barskov IV, et al.
    Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova (2018)

    110 ischemic stroke patients; Semax (6000 mcg/day intranasal) increased BDNF plasma levels and accelerated functional recovery during rehabilitation.

  • The Peptide Semax Affects the Expression of Genes Related to the Immune and Vascular Systems in Rat Brain Focal Ischemia (Parent Compound)
    Dergunova LV, Limborska SA, et al.
    BMC Genomics (2014)

    Genome-wide analysis of ischemized rat brain cortex: Semax modulated 24 vascular genes and enhanced immune-response gene expression including immunoglobulins and chemokines.

  • Semax, an Analog of ACTH(4-10), Regulates BDNF and trkB Expression in the Rat Hippocampus (Parent Compound)
    Dolotov OV, Karpenko EA, Inozemtseva LS, et al.
    Brain Research (2006)

    Single application at 50 mcg/kg produced 1.4-fold increase in BDNF protein and 1.6-fold increase in trkB tyrosine phosphorylation in rat hippocampus.

Related Peptides

BPC-157 compatible

Different mechanisms with complementary neuroprotective benefits.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.