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NA Semax Amidate

Well Studied

Enhanced Nootropic Peptide | Cognitive Enhancement & Neuroprotection

Dose 600-1200mcg per administration
Frequency 1-2x daily for 10-30 days
Cycle 10-30 days
Storage Refrigerate at 2-8°C
Accumulation Plotter

Enhanced and stabilized version of Russian nootropic Semax with superior stability, extended half-life, and enhanced bioavailability through acetylation and amidation modifications.

Mechanism of Action

Bypasses blood-brain barrier via olfactory nerves with direct brain access; enhances BDNF upregulation and hippocampal plasticity.

Key Benefits

  • Direct brain access via olfactory nerves
  • Rapid onset (15-30 minutes)
  • Proven cognitive efficacy
  • Extended half-life vs standard Semax
  • Enhanced BDNF upregulation
Molecular Weight
1,007.16 Da
Chain Length
7 amino acids
Type
Modified ACTH analog
Amino Acid Sequence
One-letter: NAMEHFPGP?
H₂N
N 1
O ‖ C
N
A 2
O ‖ C
N
M 3
O ‖ C
N
E 4
O ‖ C
N
H 5
O ‖ C
N
F 6
O ‖ C
N
P 7
O ‖ C
N
H
G 8
O ‖ C
N
P 9
O ‖ C
N
H
? 10
COOH
Asn
1

Asparagine

Position 1

Ala
2

Alanine

Position 2

Met
3

Methionine

Position 3

Glu
4

Glutamic Acid

Position 4

His
5

Histidine

Position 5

Phe
6

Phenylalanine

Position 6

Pro
7

Proline

Position 7

Gly
8

Glycine

Position 8

Pro
9

Proline

Position 9

NH₂
10

NH₂

Position 10

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Cognitive

  • Enhanced Focus and Attention

    Rapid improvement in sustained attention, working memory, and mental clarity within 15-30 minutes.

  • Memory Formation

    Enhances both short-term and long-term memory consolidation through BDNF upregulation.

  • Mental Fatigue Resistance

    Significant improvement in cognitive performance during mental fatigue, with lasting effects.

Neuroprotection

  • Stroke Recovery Support

    Accelerates functional recovery through enhanced neuroplasticity and BDNF elevation.

  • Oxidative Stress Protection

    Protects against neural oxidative damage and supports cellular repair mechanisms.

  • Neurotrophic Factor Enhancement

    Rapidly increases BDNF and TrkB receptor expression, supporting neuronal survival.

Memory

  • Episodic Memory Enhancement

    Improves episodic memory formation and recall through default mode network optimization.

  • Learning Acceleration

    Enhances acquisition of new information through improved synaptic plasticity.

Direct brain access via olfactory nerves with rapid onset and proven efficacy.

GoalDoseFrequencyRoute
Cognitive enhancement600mcg1x dailyIntranasal spray
Mental fatigue resistance800mcg1x dailyIntranasal spray
Memory enhancement600mcg2x dailyIntranasal spray
Neuroprotection1200mcg1x dailyIntranasal spray

Reconstitution Instructions

Materials Needed:
  • NA Semax Amidate lyophilized powder
  • Sterile saline solution (0.9% NaCl)
  • Nasal spray bottles (sterile)
  • Precision scale for dosing
  1. 1 Calculate desired concentration (0.1% or 0.3%)
  2. 2 Add sterile saline slowly to powder
  3. 3 Swirl gently until dissolved
  4. 4 Transfer to nasal spray bottle
  5. 5 Label and refrigerate
NA Selank Amidate

Excellent combination providing comprehensive cognitive support with nootropic and anxiolytic benefits.

synergistic
BPC-157

Different mechanisms with complementary neuroprotective benefits.

compatible
Lion's Mane

Both enhance BDNF and neuroplasticity; may provide additive cognitive benefits.

compatible
Modafinil

Both affect focus; combination may cause overstimulation in some individuals.

monitor
Blood Pressure Medications

Monitor blood pressure as Semax may affect vascular function.

monitor
MAO Inhibitors

Semax affects neurotransmitter systems; combination may cause unpredictable effects.

avoid
15-30 minutes

Initial cognitive clarity and focus improvement

1-2 hours

Peak cognitive enhancement and mental alertness

2-6 hours

Sustained attention and memory benefits

6-12 hours

Gradual return to baseline with lasting effects

Common Side Effects

  • Mild nasal irritation (intranasal)
  • Slight headache initially

Stop Signs - Discontinue if:

  • Persistent nasal irritation, burning, or bleeding
  • Severe headaches or dizziness after administration
  • Unusual mood changes, anxiety, or agitation
  • Sleep disturbances or insomnia
  • Any allergic reactions (swelling, rash, difficulty breathing)
  • Significant changes in blood pressure or heart rate

Contraindications

  • Not recommended during pregnancy
  • Active nasal congestion or sinus infection
  • Individuals on neurotransmitter-affecting medications without consultation

Good Signs

  • White, fluffy powder that reconstitutes clearly
  • Clear solution with no particles or cloudiness
  • Third-party purity testing certificates showing >98% purity

Warning Signs

  • Ensure proper cold chain maintained during shipping

Bad Signs

  • Discolored powder (yellow or brown indicates degradation)
  • Cloudiness after reconstitution indicates contamination
  • Cognitive Enhancement in Fatigued Subjects
    (1996)

    Improved attention and short-term memory in healthy subjects; 71% vs 41% memory accuracy with pronounced effects when fatigued.

  • Default Mode Network Enhancement
    (2018)

    24 subjects fMRI study. Significantly increased default mode network volume, particularly in medial frontal cortex, enhancing episodic memory.

  • Stroke Recovery and BDNF Enhancement
    (2018)

    110 participants. Increased brain-derived neurotrophic factor levels and accelerated functional recovery during rehabilitation.

  • Gene Expression and Neuroprotection
    (2014)

    Rat model revealed 96+ gene expression changes related to immune response, vascular function, and neuroprotection.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.