BPC-157

Body Protection Compound-157 | Pentadecapeptide

Weight: 1,419.53 Da
Half-life: <30 minutes
Chain: 15 amino acids
8 studies
2025 latest
4 recent
Extensively Studied
Dose 250-500mcg
Frequency Once or twice daily
Cycle 4-12 weeks depending on injury
Storage Lyophilized: freezer long-term. Reconstituted: 2-8°C for 4-6 weeks
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Synthetic peptide derived from gastric juice protein, renowned for tissue repair, inflammation reduction, and GI protection capabilities. BPC-157 promotes blood vessel formation, enhances collagen synthesis, modulates growth factor expression, and protects against tissue damage through localized or systemic delivery.

Mechanism of Action

Promotes blood vessel formation (angiogenesis), enhances collagen synthesis, modulates growth factor expression including VEGF, and protects against tissue damage through localized or systemic delivery pathways.

01 Accelerated tendon, ligament, muscle, and bone healing
02 Localized tissue repair with direct targeting
03 Superior bioavailability
04 Anti-inflammatory effects
05 Angiogenesis promotion
06 Gastric and intestinal protection

Molecular Data

Molecular Weight
1,419.53 Da
Chain Length
15 amino acids
Type
Pentadecapeptide
Amino Acid Sequence
One-letter: GKPPPGKPADDAGLV
H₂N
H
G 1
O ‖ C
N
K 2
O ‖ C
N
P 3
O ‖ C
N
P 4
O ‖ C
N
P 5
O ‖ C
N
H
G 6
O ‖ C
N
K 7
O ‖ C
N
P 8
O ‖ C
N
A 9
O ‖ C
N
D 10
O ‖ C
N
D 11
O ‖ C
N
A 12
O ‖ C
N
H
G 13
O ‖ C
N
L 14
O ‖ C
N
V 15
COOH
Gly
1

Glycine

Position 1

Lys
2

Lysine

Position 2

Pro
3

Proline

Position 3

Pro
4

Proline

Position 4

Pro
5

Proline

Position 5

Gly
6

Glycine

Position 6

Lys
7

Lysine

Position 7

Pro
8

Proline

Position 8

Ala
9

Alanine

Position 9

Asp
10

Aspartic Acid

Position 10

Asp
11

Aspartic Acid

Position 11

Ala
12

Alanine

Position 12

Gly
13

Glycine

Position 13

Leu
14

Leucine

Position 14

Val
15

Valine

Position 15

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified
Peak 0.0 mcg
Trough 0.0 mcg
SS Peak 0.0 mcg
SS Trough 0.0 mcg

Research Indications

Wound Healing
Tendon Healing most effective

Accelerated tendon-to-bone healing with improved biomechanical properties; most effective with localized injection.

Muscle Recovery most effective

Enhanced healing and reduced recovery following crush injuries and surgical procedures with direct tissue targeting.

Angiogenesis effective

Promotes blood vessel formation and improves vascularization through localized delivery.

Neurological
Neuroprotection moderate

Protective effects against neurotoxic agents and ischemic brain injury models.

Spinal Cord Injury moderate

Improved functional recovery and reduced tissue damage in spinal cord injury studies.

Peripheral Nerves moderate

Enhanced peripheral nerve regeneration and functional recovery after injury.

Gastrointestinal
Ulcer Protection most effective

Protective effects against gastric and duodenal ulcers through cytoprotective mechanisms.

Intestinal Repair effective

Acceleration of intestinal healing with reduced inflammatory markers in IBD models.

Mucosal Healing effective

Enhanced mucosal barrier function and accelerated epithelial regeneration.

Dosing Protocols

Most effective for localized healing when injected near injury site. Subcutaneous injection preferred for targeted tissue repair.

GoalDoseFrequencyRoute
Tendon/Joint healing250-500 mcg1-2x dailySubQ near injury
Serious injury500-1000 mcg2x dailySubQ near injury
General healing250-500 mcg1-2x dailySubQ or IM
Maintenance250 mcg1x dailySubQ

Reconstitution Instructions

Materials Needed:
  • Bacteriostatic water (BAC)
  • Insulin syringes (0.5-1 mL)
  • Alcohol swabs
  • Peptide vial
  • Sterile work surface
  1. 1 Clean work area and hands thoroughly
  2. 2 Calculate required BAC water volume using calculator
  3. 3 Draw BAC water into syringe
  4. 4 Inject slowly down vial side (not directly onto powder)
  5. 5 Gently swirl until dissolved (never shake)
  6. 6 Store in refrigerator, use within 28 days

Interactions

++
TB-500
Complementary healing mechanisms; often used together in the Wolverine Stack.
synergistic
+
GHRP-6
No known negative interactions.
compatible
++
Ipamorelin
BPC-157 increases GH receptor expression, amplifying growth hormone benefits.
synergistic
++
CJC-1295
BPC-157 upregulates GH receptors, enhancing effectiveness for tissue repair.
synergistic
+
Melanotan II
No known interactions; different mechanisms and receptor targets.
compatible
+
AOD-9604
Safe combination; different pathways. Often combined in regenerative protocols.
compatible

What to Expect

Week 1-2
Reduced inflammation and pain at injection site
Week 2-4
Improved healing rate and tissue repair
Week 4-8
Maximum localized healing benefits

Side Effects & Safety

Common Side Effects

  • Mild injection site redness
  • Injection site irritation
  • Possible mild digestive adjustment (oral)

Stop Signs - Discontinue if:

  • Persistent injection site reactions or infection signs
  • Unusual swelling or rash around injection area
  • Severe headaches or dizziness
  • Allergic reactions
  • Persistent or worsening digestive issues

Contraindications

  • Active cancer (due to angiogenic effects)
  • Pregnancy or breastfeeding
  • Blood thinners (consult doctor due to angiogenesis)
  • WADA prohibited for competitive athletes

Quality Checklist

Good Signs

  • White, fluffy lyophilized powder (cake) filling vial bottom
  • Crystal clear solution after reconstitution with no particles
  • Intact vacuum seal on vial

Warning Signs

  • Slight clumping that dissolves with gentle swirling (acceptable from shipping)

Bad Signs

  • Collapsed, melted, or powder stuck to vial sides (heat exposure)
  • Cloudy solution, particles, or precipitates after reconstitution
  • Discoloration of powder

References

  • Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth
    Staresinic, M., et al.
    Journal of Orthopaedic Research (2003)

    Superior tendon healing with improved biomechanical properties (increased load of failure and Young's modulus), enhanced tendon-to-bone integration, and stimulated tendocyte growth in rat models.

  • Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157
    Staresinic, M., et al.
    Journal of Orthopaedic Research (2006)

    Accelerated quadriceps healing over 72-day period with improved biomechanics, walking recovery, muscle fiber regeneration with desmin positivity, and attenuated atrophy in rat models.

  • Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats
    Perovic, D., et al.
    Journal of Orthopaedic Surgery and Research (2019)

    Significant functional recovery with improved motor function, resolved spasticity by day 15, and counteracted axonal necrosis, demyelination, and cyst formation across all stages of secondary injury.

  • BPC 157 Rescued NSAID-cytotoxicity Via Stabilizing Intestinal Permeability and Enhancing Cytoprotection
    Park, J.M., Lee, H.J., Sikiric, P., Hahm, K.B.
    Current Pharmaceutical Design (2020)

    Cytoprotective effects against NSAID-induced gastric and intestinal damage by stabilizing intestinal permeability and protecting mucosal barrier function across multiple epithelia.

  • Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation
    Hsieh, M.J., et al.
    Journal of Molecular Medicine (2017)

    Pro-angiogenic effects via VEGFR2-Akt-eNOS signaling pathway activation, increased vessel density in vivo and in vitro, and accelerated blood flow recovery in ischemic rat hind limb model.

  • Preclinical safety evaluation of body protective compound-157, a potential drug for treating various wounds
    Xu, C., et al.
    Regulatory Toxicology and Pharmacology (2020)

    Well tolerated in mice, rats, rabbits, and dogs with no serious toxicity in single-dose, repeated-dose, local tolerance, genetic, or embryo-fetal toxicity studies.

  • Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study
    Lee, E., Walker, C., Ayadi, B.
    Alternative Therapies in Health and Medicine (2024)

    Pilot human trial in 12 women (ages 39-76) with interstitial cystitis showed BPC-157 as a potential treatment for this disabling condition with no effective existing therapies.

  • Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study
    Lee, E., Burgess, K.
    Alternative Therapies in Health and Medicine (2025)

    First human IV safety data: infusions of up to 20 mg BPC-157 in 2 healthy adults showed no adverse effects on cardiac, hepatic, renal, thyroid, or glucose biomarkers.

Related Peptides

TB-500 synergistic

Complementary healing mechanisms; often used together in the Wolverine Stack.

GHRP-6 compatible

No known negative interactions.

Ipamorelin synergistic

BPC-157 increases GH receptor expression, amplifying growth hormone benefits.

Melanotan II compatible

No known interactions; different mechanisms and receptor targets.

AOD-9604 compatible

Safe combination; different pathways. Often combined in regenerative protocols.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.