PEG-MGF
Pegylated Mechano Growth Factor | IGF-1 Splice Variant
Modified IGF-1 variant with PEG attachment extending half-life from minutes to hours. Activates muscle satellite cells following mechanical stress or injury.
Mechanism of Action
Activates muscle satellite stem cells via receptor binding, stimulating MAPK/ERK signaling. Enhances protein synthesis and promotes muscle fiber repair. E-peptide domain exhibits distinct activity from mature IGF-1.
Key Benefits
- Extended half-life through PEGylation
- Satellite cell activation for muscle repair
- Recovery support following mechanical stress
- Potential neuroprotection against oxidative stress
YQPPSTNKNTKSQRRKGSTFEEHK Complex or non-standard sequence format
Muscle Repair
- Satellite Cell Activation
Primary mechanism activating dormant muscle satellite cells which fuse to damaged fibers.
- Delayed Senescence
Increases proliferative lifespan in younger muscle progenitor cells.
- Enhanced Fusion Potential
Increases activated satellite cell fusion capacity supporting repair and hypertrophy.
Tissue Regeneration
- Tendon Healing
Animal studies suggest improved Achilles tendon injury outcomes.
- Bone Regeneration
Rabbit models demonstrated faster healing via osteoblast regulation.
- Cartilage Repair
Research indicates potential for articular cartilage injury models.
Recovery
- Exercise Recovery
Naturally upregulated after mechanical stress; supplementation may enhance processes.
- Injury Recovery
Localized injection near injury sites supports targeted tissue repair.
Subcutaneous or intramuscular administration; post-workout timing aligns with natural MGF upregulation.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| General Recovery | 200mcg | 2-3x weekly | SubQ or IM |
| Targeted Muscle Recovery | 200-400mcg | Post-workout, 2-3x weekly | IM bilateral near target muscle |
| Injury Recovery | 200-400mcg | 2-3x weekly | IM near injury site |
| Conservative Protocol | 100-200mcg | 2x weekly | SubQ |
Reconstitution Instructions
- PEG-MGF lyophilized powder (typically 2mg vial)
- Bacteriostatic water
- Insulin syringes (29-31 gauge)
- Alcohol swabs
- 1 Allow vial to reach room temperature
- 2 Clean rubber stopper with alcohol swab
- 3 Draw appropriate bacteriostatic water amount
- 4 Inject slowly along vial wall, not directly onto powder
- 5 Gently swirl to dissolve; never shake
- 6 Allow 2-5 minutes for full dissolution
- 7 Store refrigerated at 2-8°C
- 8 Protect from light
Both target IGF-1 pathways; combining risks receptor overstimulation. Reduce doses significantly if combined.
HGH increases endogenous IGF-1/MGF. Combined use amplifies effects but monitor for excessive water retention and joint pain.
Complementary mechanisms. BPC-157 promotes angiogenesis; PEG-MGF activates satellite cells. Popular recovery stack.
TB-500 reduces inflammation and promotes cell migration; PEG-MGF activates muscle stem cells.
Both affect glucose metabolism. Monitor blood sugar carefully if combined.
Different regenerative pathways may enhance tissue repair through multiple mechanisms.
Reduced muscle soreness post-workout; subtle recovery improvements
Enhanced recovery between training; potential injury-related discomfort reduction
Optimal muscle repair effects; improved training capacity from better recovery
Benefits persist several weeks as tissue repair continues
Common Side Effects
- Injection site soreness
- Mild fatigue
Stop Signs - Discontinue if:
- Any unusual growths, lumps, or rapid tissue changes
- Severe injection site reactions beyond normal soreness
- Persistent headaches or vision changes
- Signs of hypoglycemia
- Unexpected swelling or edema
Contraindications
- Any history of cancer or neoplastic disease
- Pregnancy or breastfeeding
- Uncontrolled diabetes or severe hyperglycemia
Good Signs
- White or off-white fluffy cake appearance indicates proper freeze-drying
- Crystal clear solution after reconstitution with no particles
- Certificate of Analysis with HPLC purity testing (>98%)
Warning Signs
- Minor clumping that dissolves with gentle swirling is normal
Bad Signs
- Collapsed or discolored powder suggests heat degradation
- Persistent cloudiness or visible particles indicate contamination
- MGF-E Peptide Human Muscle Cell Study(2011)
Landmark study demonstrating MGF significantly increased satellite cell proliferation at 3ng/ml (P<0.001) with age-dependent effects.
- MGF Inflammatory Response Study(2018)
MGF overexpression modulated inflammatory cytokines and enhanced macrophage resolution during skeletal muscle injury recovery.
- Mechano-Growth Factor Minireview(2010)
Overview of MGF as IGF-I gene product involved in tissue repair, highlighting upregulation following exercise and injury.
Disclaimer
This information is for educational and research purposes only. Consult a healthcare professional before use.