Hexarelin (Examorelin)

Examorelin | Synthetic Growth Hormone Secretagogue

Weight: 887 Da
Half-life: 1-2 hours
Chain: 6 amino acids
4 studies
2017 latest
Well Studied
Dose 100-200 mcg per injection
Frequency 2-3 times daily for optimal GH pulses
Cycle 8-12 weeks
Storage Lyophilized: Room temperature. Reconstituted: 2-8°C, use within 28 days
Accumulation Plotter

Community Research

Join others researching Hexarelin — share findings, ask questions, and learn from real experiences

View Results Aggregated community findings
Discussion Questions & experiences
Submit Your Findings Contribute your research data

Hexarelin is one of the most potent synthetic growth hormone secretagogues available. It stimulates GH release by binding to the GHS-R1a receptor in the pituitary and hypothalamus, mimicking the action of ghrelin. Notably, Hexarelin demonstrates synergistic effects when combined with GHRH, producing GH responses greater than the arithmetic sum of either peptide alone. It also shows unique cardioprotective properties mediated through the CD36 receptor.

Mechanism of Action

Hexarelin binds to the growth hormone secretagogue receptor 1a (GHS-R1a) in the brain and pituitary gland. This binding initiates a signaling cascade that stimulates somatotroph cells in the anterior pituitary to produce and release growth hormone. Hexarelin also has slight, dose-dependent effects on prolactin, ACTH, and cortisol release. Its cardioprotective effects are mediated through CD36 receptor activation and modulation of calcium channels in cardiomyocytes.

01 Most potent GHRP for GH stimulation
02 Powerful synergy with GHRH peptides
03 Cardioprotective effects via CD36 receptor
04 Enhanced muscle growth and strength
05 Improved fat metabolism
06 Better recovery and tissue repair
07 Maintains natural GH pulsatility
08 Stable against proteolytic enzymes

Molecular Data

Molecular Weight
887 Da
Chain Length
6 amino acids
Type
Synthetic hexapeptide
Amino Acid Sequence
One-letter: H???WAW?FK?
H₂N
H 1
O ‖ C
N
H
? 2
O ‖ C
N
H
? 3
O ‖ C
N
H
? 4
O ‖ C
N
W 5
O ‖ C
N
A 6
O ‖ C
N
W 7
O ‖ C
N
H
? 8
O ‖ C
N
F 9
O ‖ C
N
K 10
O ‖ C
N
H
? 11
COOH
His
1

Histidine

Position 1

D
2

D

Position 2

2
3

2

Position 3

met
4

methyl

Position 4

Trp
5

Tryptophan

Position 5

Ala
6

Alanine

Position 6

Trp
7

Tryptophan

Position 7

D
8

D

Position 8

Phe
9

Phenylalanine

Position 9

Lys
10

Lysine

Position 10

NH2
11

NH2

Position 11

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified
Peak 0.0 mcg
Trough 0.0 mcg
SS Peak 0.0 mcg
SS Trough 0.0 mcg

Research Indications

Growth Hormone Enhancement
GH Secretion most effective

Most potent GHRP for stimulating endogenous growth hormone release from the pituitary.

Synergy with GHRH most effective

Produces synergistic GH release when combined with GHRH, greater than sum of individual effects.

IGF-1 Elevation effective

Significant increases in IGF-1 levels through enhanced GH secretion.

Cardiovascular
Cardioprotection effective

Protective effects on cardiac tissue mediated through CD36 receptor activation.

Cardiomyocyte Protection moderate

Reduces apoptosis of cardiomyocytes and controls cardiac action potential.

Calcium Channel Modulation moderate

Cardiotropic effects mediated by elevation of Ca2+ influx through voltage-gated calcium channels.

Metabolic
Fat Metabolism effective

Beneficial effects on lipid metabolism via CD36 receptor in non-obese insulin-resistant models.

Body Composition effective

Improved lean mass to fat ratio through GH and IGF-1 elevation.

Dosing Protocols

Subcutaneous or intramuscular injection. Hexarelin is rapidly absorbed after subcutaneous administration and demonstrates stability against proteolytic enzymes. Best administered on empty stomach.

GoalDoseFrequencyRoute
GH optimization100 mcg2-3x dailySubQ or IM
Enhanced results200 mcg2-3x dailySubQ or IM
With GHRH (synergy)100 mcg each2-3x dailySubQ (combined)
Cardioprotection100-200 mcg1-2x dailySubQ

Reconstitution Instructions

Materials Needed:
  • Bacteriostatic water (BAC)
  • Insulin syringes (0.5-1 mL)
  • Alcohol swabs
  • Peptide vial
  • Sterile work surface
  1. 1 Clean work area and hands thoroughly
  2. 2 Calculate required BAC water volume
  3. 3 Draw BAC water into syringe
  4. 4 Inject slowly down vial side (not directly onto powder)
  5. 5 Gently swirl until dissolved (never shake)
  6. 6 Store in refrigerator, use within 28 days

Interactions

++
CJC-1295
Powerful synergy; combination produces GH response greater than sum of individual effects.
synergistic
++
GHRH 1-29
Research confirms synergistic GH release when co-administered.
synergistic
+
GHRP-2
Similar mechanism; typically not stacked together but can be alternated.
compatible
+
GHRP-6
Same receptor target; Hexarelin is more potent with less appetite stimulation.
compatible
+
Ipamorelin
Both are GHRPs; Hexarelin is more potent but may have more side effects.
compatible

What to Expect

Immediately
GH spike within 15-30 minutes of injection
Week 1-2
Improved sleep quality and recovery
Week 2-4
Enhanced energy and well-being
Week 4-8
Noticeable improvements in body composition
Week 8-12
Maximum benefits; consider cycling to prevent desensitization

Side Effects & Safety

Common Side Effects

  • Increased appetite (less than GHRP-6)
  • Water retention
  • Tingling or numbness
  • Tiredness after injection
  • Mild headache

Stop Signs - Discontinue if:

  • Severe or persistent headaches
  • Unusual swelling
  • Signs of carpal tunnel syndrome
  • Allergic reactions

Contraindications

  • Active cancer or history of cancer
  • Pregnancy or breastfeeding
  • Pituitary disorders
  • WADA prohibited for competitive athletes

Quality Checklist

Good Signs

  • White to off-white lyophilized powder
  • Clear solution after reconstitution
  • Intact vacuum seal on vial

Warning Signs

  • Slight clumping that dissolves easily

Bad Signs

  • Discolored or yellow powder
  • Cloudy solution after reconstitution
  • Particles or precipitates in solution

References

  • Hexarelin Improves Lipid Metabolic Aberrations in Insulin-Resistant Mice
    Endocrinology (2017)

    Hexarelin treatment improved lipid metabolism via CD36 receptor in non-obese insulin-resistant MKR mice.

  • Effect of Repeated Hexarelin Administration on GH Responsivity
    European Journal of Endocrinology (1996)

    Demonstrated synergistic GH response when hexarelin co-administered with GHRH, greater than arithmetic sum.

  • Hexarelin Modulates GHS-R1a Expression
    Neuroendocrinology (2004)

    Hexarelin significantly increased pituitary and hypothalamic GHS-R1a mRNA levels.

  • Kinetics and Disposition of Hexarelin in Rats
    Drug Metabolism and Disposition (1999)

    Half-life of 75.9 min; rapidly absorbed subcutaneously; stable against proteolytic enzymes.

Related Peptides

GHRP-2 compatible

Similar mechanism; typically not stacked together but can be alternated.

GHRP-6 compatible

Same receptor target; Hexarelin is more potent with less appetite stimulation.

Ipamorelin compatible

Both are GHRPs; Hexarelin is more potent but may have more side effects.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.