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Hexarelin

Well Studied

Examorelin | Synthetic Growth Hormone Secretagogue

Dose 100-200 mcg per injection
Frequency 2-3 times daily for optimal GH pulses
Cycle 8-12 weeks
Storage Lyophilized: Room temperature. Reconstituted: 2-8°C, use within 28 days
Accumulation Plotter

Hexarelin is one of the most potent synthetic growth hormone secretagogues available. It stimulates GH release by binding to the GHS-R1a receptor in the pituitary and hypothalamus, mimicking the action of ghrelin. Notably, Hexarelin demonstrates synergistic effects when combined with GHRH, producing GH responses greater than the arithmetic sum of either peptide alone. It also shows unique cardioprotective properties mediated through the CD36 receptor.

Mechanism of Action

Hexarelin binds to the growth hormone secretagogue receptor 1a (GHS-R1a) in the brain and pituitary gland. This binding initiates a signaling cascade that stimulates somatotroph cells in the anterior pituitary to produce and release growth hormone. Hexarelin also has slight, dose-dependent effects on prolactin, ACTH, and cortisol release. Its cardioprotective effects are mediated through CD36 receptor activation and modulation of calcium channels in cardiomyocytes.

Key Benefits

  • Most potent GHRP for GH stimulation
  • Powerful synergy with GHRH peptides
  • Cardioprotective effects via CD36 receptor
  • Enhanced muscle growth and strength
  • Improved fat metabolism
  • Better recovery and tissue repair
  • Maintains natural GH pulsatility
  • Stable against proteolytic enzymes
Molecular Weight
887 Da
Chain Length
6 amino acids
Type
Synthetic hexapeptide
Amino Acid Sequence
One-letter: H???WAW?FK?
H₂N
H 1
O ‖ C
N
H
? 2
O ‖ C
N
H
? 3
O ‖ C
N
H
? 4
O ‖ C
N
W 5
O ‖ C
N
A 6
O ‖ C
N
W 7
O ‖ C
N
H
? 8
O ‖ C
N
F 9
O ‖ C
N
K 10
O ‖ C
N
H
? 11
COOH
His
1

Histidine

Position 1

D
2

D

Position 2

2
3

2

Position 3

met
4

methyl

Position 4

Trp
5

Tryptophan

Position 5

Ala
6

Alanine

Position 6

Trp
7

Tryptophan

Position 7

D
8

D

Position 8

Phe
9

Phenylalanine

Position 9

Lys
10

Lysine

Position 10

NH2
11

NH2

Position 11

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Growth Hormone Enhancement

  • GH Secretion

    Most potent GHRP for stimulating endogenous growth hormone release from the pituitary.

  • Synergy with GHRH

    Produces synergistic GH release when combined with GHRH, greater than sum of individual effects.

  • IGF-1 Elevation

    Significant increases in IGF-1 levels through enhanced GH secretion.

Cardiovascular

  • Cardioprotection

    Protective effects on cardiac tissue mediated through CD36 receptor activation.

  • Cardiomyocyte Protection

    Reduces apoptosis of cardiomyocytes and controls cardiac action potential.

  • Calcium Channel Modulation

    Cardiotropic effects mediated by elevation of Ca2+ influx through voltage-gated calcium channels.

Metabolic

  • Fat Metabolism

    Beneficial effects on lipid metabolism via CD36 receptor in non-obese insulin-resistant models.

  • Body Composition

    Improved lean mass to fat ratio through GH and IGF-1 elevation.

Subcutaneous or intramuscular injection. Hexarelin is rapidly absorbed after subcutaneous administration and demonstrates stability against proteolytic enzymes. Best administered on empty stomach.

GoalDoseFrequencyRoute
GH optimization100 mcg2-3x dailySubQ or IM
Enhanced results200 mcg2-3x dailySubQ or IM
With GHRH (synergy)100 mcg each2-3x dailySubQ (combined)
Cardioprotection100-200 mcg1-2x dailySubQ

Reconstitution Instructions

Materials Needed:
  • Bacteriostatic water (BAC)
  • Insulin syringes (0.5-1 mL)
  • Alcohol swabs
  • Peptide vial
  • Sterile work surface
  1. 1 Clean work area and hands thoroughly
  2. 2 Calculate required BAC water volume
  3. 3 Draw BAC water into syringe
  4. 4 Inject slowly down vial side (not directly onto powder)
  5. 5 Gently swirl until dissolved (never shake)
  6. 6 Store in refrigerator, use within 28 days
CJC-1295

Powerful synergy; combination produces GH response greater than sum of individual effects.

synergistic
GHRH 1-29

Research confirms synergistic GH release when co-administered.

synergistic
GHRP-2

Similar mechanism; typically not stacked together but can be alternated.

compatible
GHRP-6

Same receptor target; Hexarelin is more potent with less appetite stimulation.

compatible
Ipamorelin

Both are GHRPs; Hexarelin is more potent but may have more side effects.

compatible
Immediately

GH spike within 15-30 minutes of injection

Week 1-2

Improved sleep quality and recovery

Week 2-4

Enhanced energy and well-being

Week 4-8

Noticeable improvements in body composition

Week 8-12

Maximum benefits; consider cycling to prevent desensitization

Common Side Effects

  • Increased appetite (less than GHRP-6)
  • Water retention
  • Tingling or numbness
  • Tiredness after injection
  • Mild headache

Stop Signs - Discontinue if:

  • Severe or persistent headaches
  • Unusual swelling
  • Signs of carpal tunnel syndrome
  • Allergic reactions

Contraindications

  • Active cancer or history of cancer
  • Pregnancy or breastfeeding
  • Pituitary disorders
  • WADA prohibited for competitive athletes

Good Signs

  • White to off-white lyophilized powder
  • Clear solution after reconstitution
  • Intact vacuum seal on vial

Warning Signs

  • Slight clumping that dissolves easily

Bad Signs

  • Discolored or yellow powder
  • Cloudy solution after reconstitution
  • Particles or precipitates in solution
  • Hexarelin Improves Lipid Metabolic Aberrations in Insulin-Resistant Mice
    Endocrinology (2017)

    Hexarelin treatment improved lipid metabolism via CD36 receptor in non-obese insulin-resistant MKR mice.

  • Effect of Repeated Hexarelin Administration on GH Responsivity
    European Journal of Endocrinology (1996)

    Demonstrated synergistic GH response when hexarelin co-administered with GHRH, greater than arithmetic sum.

  • Hexarelin Modulates GHS-R1a Expression
    Neuroendocrinology (2004)

    Hexarelin significantly increased pituitary and hypothalamic GHS-R1a mRNA levels.

  • Kinetics and Disposition of Hexarelin in Rats
    Drug Metabolism and Disposition (1999)

    Half-life of 75.9 min; rapidly absorbed subcutaneously; stable against proteolytic enzymes.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.