GHRP-2 (Pralmorelin)

Growth Hormone Releasing Peptide-2 | Pralmorelin

Weight: 817.9 Da
Half-life: ~30 minutes
Chain: 6 amino acids
3 studies
2017 latest
Well Studied
Dose 100-300 mcg
Frequency 2-3x daily
Cycle 8-12 weeks
Storage 2-8°C refrigerated
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GHRP-2 is a synthetic growth hormone secretagogue that stimulates the pituitary gland to release growth hormone. It is one of the most potent members of the GHRP family, being 2-3 times more effective than GHRP-6 in stimulating GH release. Originally developed as a diagnostic agent for growth hormone deficiency, it works by mimicking ghrelin and binding to the GHS-R1a receptor.

Mechanism of Action

GHRP-2 acts as a synthetic agonist of ghrelin, binding to the growth hormone secretagogue receptor (GHS-R1a) in the hypothalamus and pituitary. This stimulates cAMP production and promotes pulsatile release of endogenous growth hormone without suppressing natural feedback loops. It works synergistically with GHRH to amplify GH secretion beyond what either peptide achieves alone.

01 Potent stimulation of natural growth hormone release
02 Enhanced muscle growth and recovery
03 Improved body composition and fat metabolism
04 Better sleep quality and recovery
05 Increased appetite (can be beneficial for bulking)
06 Maintains natural GH pulsatile release patterns
07 Synergistic effects when combined with GHRH peptides

Molecular Data

Molecular Weight
817.9 Da
Chain Length
6 amino acids
Type
Synthetic hexapeptide
Amino Acid Sequence
One-letter: ?A??AW?FK?
H₂N
H
? 1
O ‖ C
N
A 2
O ‖ C
N
H
? 3
O ‖ C
N
H
? 4
O ‖ C
N
A 5
O ‖ C
N
W 6
O ‖ C
N
H
? 7
O ‖ C
N
F 8
O ‖ C
N
K 9
O ‖ C
N
H
? 10
COOH
D
1

D

Position 1

Ala
2

Alanine

Position 2

D
3

D

Position 3

2Na
4

2Nal

Position 4

Ala
5

Alanine

Position 5

Trp
6

Tryptophan

Position 6

D
7

D

Position 7

Phe
8

Phenylalanine

Position 8

Lys
9

Lysine

Position 9

NH2
10

NH2

Position 10

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified
Peak 0.0 mcg
Trough 0.0 mcg
SS Peak 0.0 mcg
SS Trough 0.0 mcg

Research Indications

Growth Hormone Enhancement
GH Deficiency Assessment most effective

Used as a diagnostic agent in Japan for assessing growth hormone deficiency in clinical settings.

Natural GH Stimulation most effective

Stimulates endogenous growth hormone release through ghrelin receptor activation.

IGF-1 Elevation effective

Indirectly increases IGF-1 levels through enhanced GH secretion.

Body Composition
Muscle Growth effective

Enhanced muscle protein synthesis through elevated growth hormone and IGF-1 levels.

Fat Metabolism effective

Improved lipolysis and body composition through GH-mediated fat oxidation.

Recovery Enhancement effective

Faster recovery from exercise and improved sleep quality.

Protective Effects
Muscle Protection moderate

Myoprotective effects in muscle atrophy models through GHS-R1a stimulation.

Cardioprotection moderate

Cytoprotective effects observed in cardiac tissue research.

Dosing Protocols

Subcutaneous injection is the primary administration route. Best administered on an empty stomach for optimal GH release. Multiple daily doses recommended to maintain elevated GH levels.

GoalDoseFrequencyRoute
GH optimization100-150 mcg2-3x dailySubQ
Enhanced results200-300 mcg2-3x dailySubQ
With GHRH (synergy)100 mcg each2-3x dailySubQ (combined)
Pre-sleep protocol100-200 mcgBefore bedSubQ

Reconstitution Instructions

Materials Needed:
  • Bacteriostatic water (BAC)
  • Insulin syringes (0.5-1 mL)
  • Alcohol swabs
  • Peptide vial
  • Sterile work surface
  1. 1 Clean work area and hands thoroughly
  2. 2 Calculate required BAC water volume
  3. 3 Draw BAC water into syringe
  4. 4 Inject slowly down vial side (not directly onto powder)
  5. 5 Gently swirl until dissolved (never shake)
  6. 6 Store in refrigerator, use within 28 days

Interactions

++
CJC-1295
Powerful synergy; GHRH + GHRP combination amplifies GH release significantly.
synergistic
++
Mod GRF 1-29
Classic GHRP + GHRH stack for enhanced growth hormone release.
synergistic
+
Ipamorelin
Both are GHRPs; can be alternated but typically not stacked together.
compatible
+
GHRP-6
Similar mechanism; GHRP-2 is more potent with less appetite stimulation.
compatible
+
BPC-157
No known negative interactions; different mechanisms.
compatible

What to Expect

Immediately
GH spike within 15-30 minutes of injection
Week 1-2
Improved sleep quality and recovery
Week 2-4
Noticeable improvements in energy and well-being
Week 4-8
Visible changes in body composition and muscle fullness
Week 8-12
Full benefits realized with consistent use

Side Effects & Safety

Common Side Effects

  • Increased appetite (less than GHRP-6)
  • Mild water retention
  • Tingling or numbness in extremities
  • Tiredness or lethargy after injection
  • Mild headache

Stop Signs - Discontinue if:

  • Severe or persistent headaches
  • Unusual swelling in hands or feet
  • Signs of carpal tunnel syndrome
  • Allergic reactions

Contraindications

  • Active cancer or history of cancer
  • Pregnancy or breastfeeding
  • Pituitary disorders
  • Diabetic retinopathy
  • WADA prohibited for competitive athletes

Quality Checklist

Good Signs

  • White to off-white lyophilized powder
  • Clear solution after reconstitution
  • Intact vacuum seal on vial

Warning Signs

  • Slight clumping that dissolves easily

Bad Signs

  • Discolored or yellow powder
  • Cloudy solution after reconstitution
  • Particles or precipitates in solution

References

  • Growth Hormone Releasing Peptide-2 increases food intake in healthy men
    Journal of Clinical Endocrinology & Metabolism (2010)

    GHRP-2 infusion increased food intake by 35.9% compared to saline, demonstrating ghrelin-like orexigenic effects.

  • Synthetic Growth Hormone-Releasing Peptides: Cytoprotective Effects
    Clinical Medicine Insights: Cardiology (2017)

    GHRPs including GHRP-2 demonstrated significant cytoprotective effects in cardiac and extracardiac tissues.

  • GHRP-2 effects on growth hormone release in swine
    Domestic Animal Endocrinology (2000)

    Chronic GHRP-2 administration increased average daily gain by 22.35% and feed efficiency by 20.64%.

Related Peptides

Ipamorelin compatible

Both are GHRPs; can be alternated but typically not stacked together.

GHRP-6 compatible

Similar mechanism; GHRP-2 is more potent with less appetite stimulation.

BPC-157 compatible

No known negative interactions; different mechanisms.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.