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Ipamorelin

Well Studied

Growth Hormone Secretagogue | Selective GHRP

Dose 200-300 mcg per injection
Frequency 1-3 times daily depending on goals (1x for longevity, 2-3x for performance)
Cycle 3-6 months
Storage Lyophilized: Room temperature. Reconstituted: 2-8°C, use within 28 days
Accumulation Plotter

Selective GHRP that stimulates natural GH production from the pituitary with minimal cortisol and prolactin disruption. Known for its excellent safety profile and ability to produce consistent GH pulses without significant side effects common to other growth hormone releasing peptides.

Mechanism of Action

Binds selectively to ghrelin receptors in pituitary gland, stimulating natural GH release with direct systemic delivery via injection, consistent GH pulse stimulation, no significant cortisol or prolactin elevation, and minimal hunger response.

Key Benefits

  • Optimal GH stimulation with superior bioavailability
  • Body composition improvements (lean mass, fat loss)
  • Enhanced recovery and anti-aging effects
  • Minimal side effects compared to other GHRPs
  • No significant cortisol or prolactin elevation
  • Improved sleep quality
Molecular Weight
711.85 Da
Chain Length
5 amino acids
Type
Growth hormone secretagogue
Amino Acid Sequence
One-letter: UH????FK?
H₂N
U 1
O ‖ C
N
H 2
O ‖ C
N
H
? 3
O ‖ C
N
H
? 4
O ‖ C
N
H
? 5
O ‖ C
N
H
? 6
O ‖ C
N
F 7
O ‖ C
N
K 8
O ‖ C
N
H
? 9
COOH
Aib
1

Aminoisobutyric Acid

Position 1

His
2

Histidine

Position 2

D
3

D

Position 3

2
4

2

Position 4

Nal
5

Nal

Position 5

D
6

D

Position 6

Phe
7

Phenylalanine

Position 7

Lys
8

Lysine

Position 8

NH2
9

NH2

Position 9

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Growth Hormone

  • Natural GH Stimulation

    Consistent GH elevation 30-60 minutes post-injection, maintaining natural pulsatile patterns.

  • IGF-1 Enhancement

    Increases insulin-like growth factor-1 through natural GH pathways.

  • Anti-Aging Benefits

    Supports cellular regeneration, collagen synthesis, and tissue repair.

Body Composition

  • Lean Mass Development

    Promotes muscle growth and maintenance through GH-mediated pathways.

  • Fat Loss Support

    Enhances lipolysis and metabolic rate through natural GH elevation.

Recovery

  • Sleep Quality

    Improved sleep latency and increased slow-wave sleep duration.

  • Exercise Recovery

    Enhanced recovery markers and reduced soreness after training.

Most effective delivery method. Best taken on empty stomach with bedtime injection optimal for sleep benefits.

GoalDoseFrequencyRoute
General Health & Longevity200mcg1x daily before bedSubQ
Body Composition250-300mcg2x daily (morning, pre-workout)SubQ
Athletic Performance200-250mcg2-3x dailySubQ
Sleep & Recovery200mcg1x daily 30min before bedSubQ
Anti-Aging Protocol200-250mcg1-2x dailySubQ

Reconstitution Instructions

Materials Needed:
  • Bacteriostatic water (BAC)
  • Insulin syringes (0.5-1mL, 29-31 gauge)
  • Alcohol swabs
  • Sterile work surface
  1. 1 Clean work area and hands thoroughly
  2. 2 Allow refrigerated peptide to reach room temperature
  3. 3 Calculate required BAC water volume
  4. 4 Draw calculated BAC water into syringe
  5. 5 Inject BAC slowly down vial side (never directly onto powder)
  6. 6 Gently swirl until completely dissolved (never shake)
  7. 7 Store in refrigerator; use within 28 days
CJC-1295

Extends GH release for optimal hormone cycles. Popular combination.

synergistic
BPC-157

Enhances GH receptor upregulation and effectiveness.

synergistic
TB-500

Complementary for recovery and tissue repair.

compatible
Sermorelin

Both stimulate GH; choose one to avoid receptor oversaturation.

monitor
GHRP-2

Redundant GH pathways may cause receptor desensitization.

avoid
GHRP-6

Similar mechanism with higher hunger effects; redundant.

avoid
Week 1-2

Improved sleep quality and morning energy

Week 2-4

Enhanced exercise recovery and reduced soreness

Week 4-8

Body composition improvements with increased lean mass

Week 8-12

Continued muscle tone, skin quality, and energy improvements

Common Side Effects

  • Mild hunger increase 20-30 minutes post-injection
  • Slight drowsiness when taken before bed
  • Water retention (mild)

Stop Signs - Discontinue if:

  • Signs of receptor desensitization (reduced response after 3-4 months)
  • Unusual joint pain or swelling
  • Persistent numbness or tingling

Contraindications

  • Pregnancy or breastfeeding
  • Active cancer or history of cancer
  • Severe kidney or liver disease

Good Signs

  • White, fine crystalline powder with no clumping
  • Clear solution after BAC water reconstitution
  • Mild hunger response 20-30 minutes post-injection
  • Slight drowsiness at bedtime doses

Warning Signs

  • Minimal or no physiological response after 2 weeks (check source)

Bad Signs

  • Yellow or discolored powder (suggests degradation)
  • Cloudy solution after reconstitution
  • No response after extended use
  • Growth Hormone Stimulation Study
    (2019)

    200mcg daily for 8 weeks showed consistent GH elevation 30-60 min post-injection in adults.

  • Body Composition Clinical Trial
    (2020)

    250mcg daily for 12 weeks demonstrated lean mass gains and bone density improvements in adults 45+.

  • Sleep Quality Research
    (2021)

    200mcg before bed improved sleep latency and increased slow-wave sleep duration in adults with sleep issues.

  • Athletic Performance Study
    (2022)

    Enhanced recovery markers and muscle protein synthesis in athletic populations.

  • Safety and Tolerability Analysis
    (2023)

    Confirmed excellent tolerability profile with minimal side effects across multiple studies.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.