Cardiogen (AEDR)

AEDR | Cardiovascular Bioregulator Peptide

Weight: 460 Da
Half-life: Minutes (short peptide); effects persist via epigenetic changes
Chain: 4 amino acids
3 studies
2021 latest
Moderate Research
Dose 10-20 mg daily
Frequency Once daily for 10-20 consecutive days
Cycle 10-20 days per cycle
Storage Capsules: room temperature; Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C refrigerated

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Cardiogen is a Khavinson bioregulator peptide consisting of four amino acids, derived from heart tissue research. Unlike larger peptides that work on cell surfaces, Cardiogen penetrates directly to the cell nucleus where it binds to specific DNA regions to regulate gene expression. This epigenetic mechanism supports tissue repair and improves cardiovascular function, particularly benefiting the heart and blood vessels.

Mechanism of Action

Cardiogen works through epigenetic regulation by penetrating cell nuclei and interacting with specific DNA regions, histones, and nucleosomes. It regulates which genes are activated or suppressed without changing DNA sequence. This mechanism supports cardiac tissue repair, enhances myocardial function, and improves cardiovascular tissue regeneration by influencing gene expression in heart cells.

01 Supports cardiac tissue repair and regeneration
02 Regulates cardiovascular gene expression
03 Improves myocardial function
04 May support post-cardiac event recovery
05 Epigenetic mechanism for targeted action
06 Works at DNA/nuclear level
07 Part of comprehensive anti-aging protocols
08 Well-researched Khavinson peptide

Molecular Data

Molecular Weight
460 Da
Chain Length
4 amino acids
Type
Tetrapeptide bioregulator
Amino Acid Sequence
One-letter: AEDR
H₂N
A 1
O ‖ C
N
E 2
O ‖ C
N
D 3
O ‖ C
N
R 4
COOH
Ala
1

Alanine

Position 1

Glu
2

Glutamic Acid

Position 2

Asp
3

Aspartic Acid

Position 3

Arg
4

Arginine

Position 4

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Research Indications

Cardiovascular Support
Cardiac Tissue Repair effective

Supports heart tissue repair through gene expression regulation at the nuclear level.

Myocardial Function moderate

May improve overall myocardial function and cardiac performance.

Cardiovascular Aging moderate

Addresses age-related cardiovascular decline through bioregulation.

Anti-Aging
Epigenetic Regulation moderate

Influences gene expression to support tissue repair without altering DNA sequence.

Tissue Regeneration moderate

Promotes cardiac tissue regeneration at the cellular level.

Dosing Protocols

Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles, often repeated 2-3 times per year.

GoalDoseFrequencyRoute
Standard protocol10-20 mgDaily for 10-20 daysOral capsules
Maintenance10 mg2-3 cycles yearlyOral capsules

Interactions

++
Vesugen
Complementary cardiovascular bioregulators - Cardiogen for heart, Vesugen for vessels.
synergistic
++
Epitalon
Often combined in comprehensive anti-aging Khavinson protocols.
synergistic
+
Thymalin
Different organ targets; can be used in comprehensive bioregulator protocols.
compatible
+
Pinealon
Part of Khavinson bioregulator family; targets different tissue.
compatible

What to Expect

During cycle
Gene expression modulation begins
Post-cycle
Effects persist due to epigenetic changes
Months
Cardiovascular function improvements
Long-term
Cumulative benefits with periodic cycles

Side Effects & Safety

Common Side Effects

  • Generally well-tolerated
  • Minimal side effects reported

Stop Signs - Discontinue if:

  • Allergic reactions
  • Unusual cardiac symptoms

Contraindications

  • Active cardiac emergencies (seek medical care)
  • Known hypersensitivity
  • Pregnancy or breastfeeding

Quality Checklist

Good Signs

  • White powder or capsules
  • Clear solution if reconstituted
  • Proper packaging and labeling

Warning Signs

  • Unknown source or purity

Bad Signs

  • Discoloration
  • Unusual odor
  • Damaged packaging

References

  • Peptide Regulation of Gene Expression: A Systematic Review
    Molecules (MDPI) (2021)

    Short peptides can penetrate nuclei, interact with DNA and histones to regulate gene expression.

  • Cardiogen Bioregulator Research
    Bulletin of Experimental Biology and Medicine (2015)

    Demonstrated effects on cardiac tissue through gene expression modulation.

  • Khavinson Peptide Bioregulators Overview
    Advances in Gerontology (2020)

    Comprehensive review of bioregulator peptides and their epigenetic mechanisms.

Related Peptides

Vesugen synergistic

Complementary cardiovascular bioregulators - Cardiogen for heart, Vesugen for vessels.

Epitalon synergistic

Often combined in comprehensive anti-aging Khavinson protocols.

Thymalin compatible

Different organ targets; can be used in comprehensive bioregulator protocols.

Pinealon compatible

Part of Khavinson bioregulator family; targets different tissue.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.