5-Amino-1MQ
NNMT Inhibitor | Longevity & Metabolic Enhancement
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Not a true peptide, but a small molecule compound used in longevity and metabolic optimization protocols.
Mechanism of Action
Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.
Key Benefits
- Enhanced NAD+ levels
- Improved mitochondrial function
- Better energy metabolism
- Enhanced cellular repair
- Improved insulin sensitivity
- Longevity support
- Convenient daily oral dosing
Longevity
- NAD+ Enhancement
Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.
- Mitochondrial Function
Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging.
- Cellular Repair
Enhanced NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance.
Metabolism
- Energy Metabolism
Improvement through enhanced mitochondrial efficiency.
- Insulin Sensitivity
Enhancement via cellular energy optimization.
- Metabolic Flexibility
Improved glucose/fat substrate switching.
Weight Loss
- Metabolic Rate Enhancement
Supports increased basal metabolic rate.
- Fat Oxidation
Improvements in fat burning capacity.
Most common delivery method. Take with food to improve absorption and reduce potential GI effects. Consistent daily timing helps maintain steady NAD+ levels. Morning or early afternoon dosing preferred.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Conservative initiation | 25mg | 1x daily | Oral with food |
| Standard starting dose | 50mg | 1x daily | Oral with food |
| Typical maintenance | 75mg | 1x daily | Oral with food |
| Maximum dose | 100mg | 1x daily | Oral with food |
| Split dosing protocol | 50mg | 2x daily | Oral with meals |
May work synergistically by preventing breakdown while supporting production.
Both support longevity; resveratrol activates sirtuins while 5-Amino-1MQ provides NAD+ substrate.
Both affect metabolic pathways; combination may enhance effects but requires careful monitoring.
No known interactions; different mechanisms with potential complementary benefits.
Limited interaction data; consult healthcare provider before combining.
Both affect metabolic pathways; potential additive glucose metabolism effects.
Gradual energy increase and mental clarity
Enhanced exercise performance and recovery
Improved metabolic markers and body composition
Sustained longevity benefits and cellular health improvements
Common Side Effects
- Generally minimal side effects
- Occasional mild GI adjustment
- Potential sleep interference if dosed late in day
Stop Signs - Discontinue if:
- Severe gastrointestinal upset or persistent nausea
- Unusual fatigue or weakness (opposite of expected effect)
- Persistent headaches or dizziness
- Sleep disturbances or insomnia
- Allergic reactions (rash, swelling, difficulty breathing)
- Significant mood changes or anxiety
Contraindications
- Pregnancy or breastfeeding
- Pre-existing metabolic conditions (consult healthcare provider)
Good Signs
- White to off-white (or orange/amber for powder) appearance
- Uniform color and size with clear labeling and batch information
- Third-party testing certificates (COA) with >98% purity
- Proper pharmaceutical packaging with moisture protection
- Clear expiration dates and professional labeling
Warning Signs
- Moisture damage or clumping may indicate degradation
Bad Signs
- Sticky, discolored, or heat-damaged appearance
- Unusual odor (should be relatively odorless)
- Strong chemical odors indicating contamination
- Cloudy reconstitution solution (injectables)
- Mouse Obesity Study - Neelakantan et al.(2018)
Diet-induced obese mice showed 5.1% weight loss, 30% adipocyte size reduction at 60mg/kg/day. Human equivalent ~5mg/kg/day using FDA allometric scaling.
- Rat Pharmacokinetics Study(2021)
Demonstrated 38.4% oral bioavailability, half-life 6.9hr (oral) and 3.8hr (IV). Supports oral administration viability.
- Muscle Function in Aged Mice(2024)
40% grip strength improvement in sedentary mice, 60% with exercise at 10mg/kg/day SubQ for 8 weeks. No adverse effects observed.
Disclaimer
This information is for educational and research purposes only. Consult a healthcare professional before use.