5-Amino-1MQ
NNMT Inhibitor | Longevity & Metabolic Enhancement
Community Research
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5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Not a true peptide, but a small molecule compound used in longevity and metabolic optimization protocols.
Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.
Molecular Data
Research Indications
Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.
Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging.
Enhanced NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance.
Improvement through enhanced mitochondrial efficiency.
Enhancement via cellular energy optimization.
Improved glucose/fat substrate switching.
Supports increased basal metabolic rate.
Improvements in fat burning capacity.
Dosing Protocols
Most common delivery method. Take with food to improve absorption and reduce potential GI effects. Consistent daily timing helps maintain steady NAD+ levels. Morning or early afternoon dosing preferred.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Conservative initiation | 25mg | 1x daily | Oral with food |
| Standard starting dose | 50mg | 1x daily | Oral with food |
| Typical maintenance | 75mg | 1x daily | Oral with food |
| Maximum dose | 100mg | 1x daily | Oral with food |
| Split dosing protocol | 50mg | 2x daily | Oral with meals |
Interactions
What to Expect
Side Effects & Safety
Common Side Effects
- Generally minimal side effects
- Occasional mild GI adjustment
- Potential sleep interference if dosed late in day
Stop Signs - Discontinue if:
- Severe gastrointestinal upset or persistent nausea
- Unusual fatigue or weakness (opposite of expected effect)
- Persistent headaches or dizziness
- Sleep disturbances or insomnia
- Allergic reactions (rash, swelling, difficulty breathing)
- Significant mood changes or anxiety
Contraindications
- Pregnancy or breastfeeding
- Pre-existing metabolic conditions (consult healthcare provider)
Quality Checklist
Good Signs
- White to off-white (or orange/amber for powder) appearance
- Uniform color and size with clear labeling and batch information
- Third-party testing certificates (COA) with >98% purity
- Proper pharmaceutical packaging with moisture protection
- Clear expiration dates and professional labeling
Warning Signs
- Moisture damage or clumping may indicate degradation
Bad Signs
- Sticky, discolored, or heat-damaged appearance
- Unusual odor (should be relatively odorless)
- Strong chemical odors indicating contamination
- Cloudy reconstitution solution (injectables)
References
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in miceNeelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJBiochemical Pharmacology (2018)
Diet-induced obese mice showed significant weight loss and adipocyte size reduction with 5-amino-1MQ treatment. Demonstrated that NNMT inhibition increases energy expenditure, reduces body weight and white adipose mass, improves insulin sensitivity, and normalizes glucose tolerance.
- Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studiesKannt A et al.Journal of Pharmaceutical and Biomedical Analysis (2021)
Demonstrated 38.4% oral bioavailability, half-life 6.9hr (oral) and 3.8hr (IV). Validated sensitive LC-MS/MS method for pharmacokinetic assessment supporting oral administration viability.
- Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged miceNeelakantan H et al.Scientific Reports (2024)
NNMTi-treated aged sedentary mice showed ~40% greater grip strength than controls. Combined with exercise, 60% grip strength increase. Also improved intramuscular lipid content and gastrocnemius fiber cross-sectional area.
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Disclaimer
This information is for educational and research purposes only. Consult a healthcare professional before use.