Vilon (KE)

KE Dipeptide | Thymus Immune Bioregulator

Weight: 275 Da
Half-life: Not established
Chain: 2 amino acids
4 studies
2022 latest
Moderate Research
Dose 10-20 mg per day (oral capsules) or 10 mg (injectable)
Frequency Daily for 10-20 consecutive days (Khavinson bioregulator cycle)
Cycle 10-20 day cycle (typical 10 days in research)
Storage Oral capsules: room temperature; Lyophilized powder/reconstituted: 2-8°C refrigerated

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Vilon is a Khavinson bioregulator dipeptide (KE) consisting of lysine and glutamic acid, originally isolated from thymus gland extracts. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, it acts as a molecular signaling compound that restores normal gene expression and protein synthesis in immune and epithelial cells. Research shows Vilon increases mean lifespan by 20-40% in animal studies and suppresses tumor development.

Mechanism of Action

Vilon works through epigenetic modulation, restoring chromatin structure and gene expression in immune cells. It stimulates thymocyte proliferation, activates T-helper cells, and increases the proliferative index in thymus tissue (from 26% to 37% in studies). The peptide modulates tyrosine phosphorylation of mitogen-activated cytoplasmic kinases and helps rejuvenate aged immune systems by restoring proper gene expression patterns.

01 Increases mean lifespan 20-40% in animal models
02 Suppresses tumor development
03 Stimulates thymocyte proliferation
04 Activates T-helper cells
05 Restores chromatin structure in aged lymphocytes
06 Enhances intestinal barrier function
07 Improves enzyme activity in aged tissue
08 Part of comprehensive longevity protocols

Molecular Data

Molecular Weight
275 Da
Chain Length
2 amino acids
Type
Dipeptide bioregulator
Amino Acid Sequence
One-letter: KE
H₂N
K 1
O ‖ C
N
E 2
COOH
Lys
1

Lysine

Position 1

Glu
2

Glutamic Acid

Position 2

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Research Indications

Immune Support
Thymus Rejuvenation effective

Stimulates thymocyte proliferation and enlarges thymic lobules.

T-Cell Activation effective

Activates T-helper cells and improves immune response.

Age-Related Immune Decline effective

Restores chromatin structure and gene expression in aged lymphocytes.

Anti-Aging
Lifespan Extension effective

Long-term treatment increased mean lifespan 20-40% in rodent studies.

Tumor Suppression moderate

Suppresses development of spontaneous and induced tumors.

Tissue Regeneration moderate

Promotes recovery in tissues exposed to radiation damage.

GI Health
Intestinal Function moderate

Restores brush border membrane enzyme levels in aged animals.

Barrier Function moderate

Enhances intestinal barrier function in aged rats.

Dosing Protocols

Available in capsule form for oral administration. As the shortest Khavinson peptide (just 2 amino acids), Vilon is easily absorbed orally. Typical protocol involves 10-20 day cycles, repeated 2-3 times per year.

GoalDoseFrequencyRoute
Standard protocol10-20 mgDaily for 10-20 daysOral capsules
Maintenance10 mg2-3 cycles yearlyOral capsules

Interactions

++
Thymalin
Both target thymus/immune system; complementary mechanisms.
synergistic
++
Epitalon
Often combined in comprehensive anti-aging Khavinson protocols.
synergistic
++
Crystagen
Both have immunoprotecting properties; different mechanisms.
synergistic
+
Thymogen
Related immune peptides; can be used in comprehensive protocols.
compatible

What to Expect

During cycle
Immune activation and gene expression modulation begins
Post-cycle
Effects persist due to epigenetic changes
Weeks-Months
Immune function improvements
Long-term
Cumulative benefits; longevity effects in animal models

Side Effects & Safety

Common Side Effects

  • Generally well-tolerated
  • Minimal side effects reported

Stop Signs - Discontinue if:

  • Allergic reactions
  • Unusual immune symptoms

Contraindications

  • Active autoimmune flares (consult physician)
  • Known hypersensitivity
  • Pregnancy or breastfeeding

Quality Checklist

Good Signs

  • White powder or capsules
  • Clear solution if reconstituted
  • Proper packaging and labeling

Warning Signs

  • Unknown source or purity

Bad Signs

  • Discoloration
  • Unusual odor
  • Damaged packaging

References

  • Peptide Bioregulators Increase Lifespan
    Biogerontology (2003)

    Long-term treatment with peptide preparations including Vilon increased mean lifespan 20-40% and suppressed tumorigenesis.

  • Vilon Effects on Aged Lymphocytes
    Bulletin of Experimental Biology and Medicine (2002)

    Vilon improved lymphocytes from old people by restoring chromatin structure and gene expression.

  • Peptides Regulating Proliferative Activity in THP-1 Cells
    PMC (2022)

    Vilon and other Khavinson peptides modulate key proliferative patterns and tyrosine phosphorylation of kinases.

  • Short Peptide Immunoprotecting Properties
    Advances in Gerontology (2018)

    Vilon and related peptides possess age-associated immunoprotecting properties in the spleen.

Related Peptides

Thymalin synergistic

Both target thymus/immune system; complementary mechanisms.

Epitalon synergistic

Often combined in comprehensive anti-aging Khavinson protocols.

Crystagen synergistic

Both have immunoprotecting properties; different mechanisms.

Thymogen compatible

Related immune peptides; can be used in comprehensive protocols.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.