Livagen (KEDA)

KEDA Tetrapeptide | Liver Bioregulator

Weight: 432 Da
Half-life: Not established
Chain: 4 amino acids
4 studies
2020 latest
Moderate Research
Dose 10-20 mg daily
Frequency Daily for 10-20 days per cycle
Cycle 10-20 days
Storage Oral capsules: Room temperature. Injectable reconstituted: 2-8°C refrigerated

Community Research

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Livagen is a Khavinson bioregulator tetrapeptide (KEDA) with significant hepatoprotective and immunomodulatory properties. Structurally similar to Epitalon, it normalizes immune and antioxidant status while restoring liver function in hepatitis conditions. Livagen is best known for its ability to decondense chromatin, activating silent genes including ribosomal genes to boost protein synthesis and cellular activity. Maximum protective effects occur during aging.

Mechanism of Action

Livagen works through direct effects on DNA structure and function. It decondenses chromatin (tightly packed DNA), increasing expression of certain genes and improving the 'youthful' profile of cells. The peptide activates multiple genes in lymphocytes, including previously silent ribosomal genes, boosting protein synthesis and cell activity. It exhibits hepatoprotective effects through normalizing immune and antioxidant status in liver tissue.

01 Significant hepatoprotective properties
02 Decondenses chromatin to activate genes
03 Restores liver function in hepatitis
04 Normalizes immune status
05 Improves antioxidant status
06 Activates ribosomal gene expression
07 Maximum effects occur during aging
08 Boosts protein synthesis and cell activity

Molecular Data

Molecular Weight
432 Da
Chain Length
4 amino acids
Type
Tetrapeptide bioregulator
Amino Acid Sequence
One-letter: KEDA
H₂N
K 1
O ‖ C
N
E 2
O ‖ C
N
D 3
O ‖ C
N
A 4
COOH
Lys
1

Lysine

Position 1

Glu
2

Glutamic Acid

Position 2

Asp
3

Aspartic Acid

Position 3

Ala
4

Alanine

Position 4

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Research Indications

Liver Support
Hepatoprotection effective

Protects liver tissue through normalizing immune and antioxidant status.

Hepatitis Support effective

Restores liver functions in both acute and chronic hepatitis models.

Liver Fibrosis moderate

Shows protective properties in liver fibroid induration models.

Anti-Aging
Chromatin Remodeling effective

Decondenses chromatin to restore youthful gene expression patterns.

Age-Related Liver Decline effective

Maximum hepatoprotective effects occur during aging.

Gene Activation moderate

Activates silent genes including ribosomal genes for improved protein synthesis.

Immune Support
Immunomodulation moderate

Normalizes immune function alongside liver protective effects.

Dosing Protocols

Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles, often repeated 2-3 times per year.

GoalDoseFrequencyRoute
Standard protocol10-20 mgDaily for 10-20 daysOral capsules
Maintenance10 mg2-3 cycles yearlyOral capsules

Interactions

++
Epitalon
Structurally similar; often combined in comprehensive anti-aging protocols.
synergistic
++
Glutathione
Both support liver function and antioxidant status.
synergistic
++
Ovagen
Complementary liver bioregulators with different sequences.
synergistic
+
Vilon
Different organ targets; can be combined in bioregulator protocols.
compatible

What to Expect

During cycle
Chromatin remodeling and gene expression changes begin
Post-cycle
Effects persist due to epigenetic changes
Weeks-Months
Liver function improvements
Long-term
Cumulative benefits with periodic cycles

Side Effects & Safety

Common Side Effects

  • Generally well-tolerated
  • Minimal side effects reported

Stop Signs - Discontinue if:

  • Allergic reactions
  • Unusual liver symptoms

Contraindications

  • Active liver emergencies (seek medical care)
  • Known hypersensitivity
  • Pregnancy or breastfeeding

Quality Checklist

Good Signs

  • White powder or capsules
  • Clear solution if reconstituted
  • Proper packaging and labeling

Warning Signs

  • Unknown source or purity

Bad Signs

  • Discoloration
  • Unusual odor
  • Damaged packaging

References

  • Influence of KEDA Tetrapeptide on Organism Physiological Function
    Advances in Gerontology (2020)

    KEDA exhibits hepatoprotective, immunomodulatory, and geroprotective properties with maximum effects during aging.

  • Effects of Livagen Peptide on Chromatin Activation in Lymphocytes from Old People
    Bulletin of Experimental Biology and Medicine (2002)

    Livagen activates chromatin decondensation and multiple genes in aged lymphocytes.

  • Hepatoprotective Properties of KEDA in Hepatitis Models
    Experimental Biology and Medicine (2018)

    KEDA normalizes immune and antioxidant status and restores liver functions in hepatitis.

  • Khavinson Peptide Bioregulators
    Advances in Gerontology (2020)

    Comprehensive review of bioregulator peptides and their epigenetic mechanisms.

Related Peptides

Epitalon synergistic

Structurally similar; often combined in comprehensive anti-aging protocols.

Glutathione synergistic

Both support liver function and antioxidant status.

Ovagen synergistic

Complementary liver bioregulators with different sequences.

Vilon compatible

Different organ targets; can be combined in bioregulator protocols.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.