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Adalank

Emerging

N-Acetyl Selank Amidate | Enhanced Tuftsin Analog

Dose 200-500mcg
Frequency Once or twice daily
Cycle 2-4 weeks
Storage Lyophilized: room temp or freezer. Reconstituted: 2-8°C for 14-30 days

Enhanced derivative of Selank with improved stability, blood-brain barrier penetration, and extended half-life compared to parent compound. Parent compound Selank approved in Russia since early 2000s.

Mechanism of Action

Modulates GABAergic neurotransmission, upregulates hippocampal BDNF, influences serotonin metabolism, and provides immunomodulatory effects without benzodiazepine-like dependency.

Key Benefits

  • Potent anxiolytic effects without sedation
  • Enhanced cognitive function
  • Stress resilience
  • Improved mood and emotional stability
  • Neuroprotection via BDNF upregulation
  • No tolerance, dependency, or withdrawal
Molecular Weight
792.93 Da
Chain Length
7 amino acids
Type
Modified heptapeptide
Amino Acid Sequence
One-letter: ?TKPRPGP?
H₂N
H
? 1
O ‖ C
N
T 2
O ‖ C
N
K 3
O ‖ C
N
P 4
O ‖ C
N
R 5
O ‖ C
N
P 6
O ‖ C
N
H
G 7
O ‖ C
N
P 8
O ‖ C
N
H
? 9
COOH
Ac
1

Ac

Position 1

Thr
2

Threonine

Position 2

Lys
3

Lysine

Position 3

Pro
4

Proline

Position 4

Arg
5

Arginine

Position 5

Pro
6

Proline

Position 6

Gly
7

Glycine

Position 7

Pro
8

Proline

Position 8

NH2
9

NH2

Position 9

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Anxiety

  • Generalized Anxiety Disorder

    Clinical trials showed effects comparable to benzodiazepines; 40% rapid response within 1-3 days.

  • Stress-Related Anxiety

    Reduces stress hormones and balances neurotransmitters without sedation.

  • Anxiety without Sedation

    Unlike benzodiazepines, provides relief without tolerance, withdrawal, or dependency.

Cognitive

  • Cognitive Enhancement

    Improves focus, attention, and mental clarity.

  • Memory Protection

    BDNF-mediated neuroplasticity supports memory formation.

Neuroprotection

  • BDNF Upregulation

    Rapidly elevates BDNF expression, supporting neuronal survival.

  • Stress Resilience

    Enhances ability to cope with psychological stress.

Subcutaneous injection to belly, thigh, or upper arm. Morning administration aligns with cortisol rhythms.

GoalDoseFrequencyRoute
Anxiety Reduction200-300mcg1x daily (morning)SubQ
Cognitive Enhancement200-500mcg1x dailySubQ
Stress Management200-300mcg2x daily (morning, afternoon)SubQ
Initial Trial100-200mcg1x dailySubQ

Reconstitution Instructions

Materials Needed:
  • Bacteriostatic water (BAC)
  • Insulin syringes
  • Alcohol swabs
  • Sterile work surface
  1. 1 Clean work area thoroughly
  2. 2 Calculate BAC water volume
  3. 3 Draw water into syringe
  4. 4 Inject slowly down vial side (not directly onto powder)
  5. 5 Gently swirl until dissolved (never shake vigorously)
  6. 6 Store at 2-8°C
  7. 7 Use within 14-30 days
Selank

Adalank is enhanced derivative with improved stability and longer half-life.

compatible
Semax

Both are Russian nootropic peptides with different mechanisms.

compatible
BPC-157

Different mechanisms; Adalank targets neurological pathways, BPC-157 focuses on tissue repair.

compatible
Diazepam

Enhances benzodiazepine effects while reducing side effects in research studies.

synergistic
MAOIs

Consult healthcare provider; affects neurotransmitter systems.

monitor
Days 1-3

40% may experience rapid anxiety reduction

Week 1-2

Gradual anxiety relief, improved mood, enhanced stress resilience

Week 2-4

Cognitive enhancement, improved focus, BDNF-mediated neuroplasticity

Week 4+

Sustained anxiolytic and cognitive benefits

Common Side Effects

  • Parent compound has high safety profile in Russian clinical research
  • Minimal side effects reported

Stop Signs - Discontinue if:

  • Unusual or persistent headaches
  • Significant mood changes or depression
  • Unexpected sedation or extreme fatigue
  • Unusual neurological symptoms
  • Persistent injection site reactions or nasal irritation
  • Severe gastrointestinal distress

Contraindications

  • Experimental peptide with limited direct human research on N-Acetyl form
  • Not recommended during pregnancy or breastfeeding
  • Consult healthcare provider before use with psychiatric medications

Good Signs

  • White, fluffy powder; proper freeze-drying indicated
  • Clear solution after reconstitution; no particles or cloudiness
  • Proper labeling with peptide name, batch number, manufacturing date

Warning Signs

  • Slight compaction from shipping acceptable if powder dissolves with gentle swirling

Bad Signs

  • Discoloration or yellowing indicates oxidation or degradation
  • Persistent cloudiness or particles indicate degraded or contaminated peptide
  • Selank for GAD - Non-inferiority Trial
    (N/A)

    62 patients with GAD; 2700mcg/day intranasal; 14 days. Anxiolytic effects comparable to medazepam; 40% rapid response within 1-3 days.

  • Selank and BDNF Regulation in Hippocampus
    (N/A)

    Rat study; intranasal administration. Rapidly elevated BDNF expression, confirming neurotrophin involvement.

  • Peptide Selank Enhances Diazepam Effects
    (N/A)

    Rats in chronic mild stress model. Enhanced anxiolytic effects while reducing memory impairment and sedation.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.