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Cortagen

Moderate Research

AEDP | Brain Cortex Bioregulator Peptide

Dose 10-20 mg daily
Frequency Once daily for 10-20 consecutive days
Cycle 10-20 days per cycle
Storage Capsules: room temperature; Injectable lyophilized: 2-8°C; Reconstituted: 2-8°C refrigerated

Cortagen is a Khavinson bioregulator tetrapeptide (AEDP) with primary effects on the brain and central nervous system. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it regulates inflammatory responses in the nervous system, restores balance between pro- and anti-oxidative processes, and stimulates interleukin-2 expression. Research shows potential benefits for ischemic brain injury recovery, nerve regeneration, and reducing autoimmune reactions affecting the CNS.

Mechanism of Action

Cortagen works through epigenetic regulation by penetrating cell nuclei and interacting with DNA to modulate gene expression. In the heart, it affects genes including Pass1, Hsc70, Bmp2, Wnt4, Eps15, and Eps15-rs. It powerfully regulates inflammatory responses in the nervous system, helping restore proper balance between oxidative and anti-oxidative processes. Cortagen stimulates IL-2 expression and helps regulate immune function, particularly by reducing autoimmune reactions.

Key Benefits

  • Regulates central nervous system function
  • Powerful anti-inflammatory effects in brain
  • Supports nerve regeneration
  • Restores oxidative balance
  • Stimulates interleukin-2 expression
  • Reduces autoimmune reactions
  • Beneficial after ischemic brain injury
  • Modulates gene expression in neural tissue
Molecular Weight
416 Da
Chain Length
4 amino acids
Type
Tetrapeptide bioregulator
Amino Acid Sequence
One-letter: AEDP
H₂N
A 1
O ‖ C
N
E 2
O ‖ C
N
D 3
O ‖ C
N
P 4
COOH
Ala
1

Alanine

Position 1

Glu
2

Glutamic Acid

Position 2

Asp
3

Aspartic Acid

Position 3

Pro
4

Proline

Position 4

N-terminus C-terminus
Hydrophobic
Polar
Positive (+)
Negative (-)
Modified

Neurological Support

  • Ischemic Brain Injury Recovery

    Shows beneficial long-term results in research following ischemic brain injury.

  • Nerve Regeneration

    Research demonstrates effects on restoration of injured nerve function.

  • Neuroinflammation

    Regulates inflammatory response in the nervous system.

Immune Regulation

  • Autoimmune Modulation

    Helps regulate immune function by reducing autoimmune reactions.

  • IL-2 Stimulation

    Stimulates interleukin-2 expression for immune regulation.

Anti-Aging

  • Oxidative Balance

    Restores balance between pro- and anti-oxidative processes.

  • Brain Aging

    Addresses age-related CNS changes through bioregulation.

Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles, often repeated 2-3 times per year.

GoalDoseFrequencyRoute
Standard protocol10-20 mgDaily for 10-20 daysOral capsules
Maintenance10 mg2-3 cycles yearlyOral capsules
Pinealon

Complementary CNS bioregulators; Cortagen for cortex, Pinealon for general brain.

synergistic
Epitalon

Often combined in comprehensive anti-aging Khavinson protocols.

synergistic
Thymalin

Different organ targets; can be used in comprehensive bioregulator protocols.

compatible
Cardiogen

Part of Khavinson bioregulator family; targets different tissue.

compatible
During cycle

Gene expression modulation begins

Post-cycle

Effects persist due to epigenetic changes

Weeks-Months

Neurological function improvements

Long-term

Cumulative benefits with periodic cycles

Common Side Effects

  • Generally well-tolerated
  • Minimal side effects reported

Stop Signs - Discontinue if:

  • Allergic reactions
  • Unusual neurological symptoms

Contraindications

  • Active neurological emergencies (seek medical care)
  • Known hypersensitivity
  • Pregnancy or breastfeeding

Good Signs

  • White powder or capsules
  • Clear solution if reconstituted
  • Proper packaging and labeling

Warning Signs

  • Unknown source or purity

Bad Signs

  • Discoloration
  • Unusual odor
  • Damaged packaging
  • Effect of Cortagen on Gene Expression in Mouse Heart
    Neuroendocrinology Letters (2004)

    Cortagen affects expression of genes including Pass1, Hsc70, Bmp2, Wnt4, Eps15 in heart tissue.

  • Delayed Effect of Cortagen on Restoration of Injured Nerve Function
    Doklady Biological Sciences (2002)

    Demonstrated effects on nerve function restoration following injury.

  • Effect of Tetrapeptide Cortagen on Regeneration of Sciatic Nerve
    Bulletin of Experimental Biology and Medicine (2000)

    Research on nerve regeneration effects of Cortagen tetrapeptide.

  • Khavinson Peptide Bioregulators
    Advances in Gerontology (2020)

    Comprehensive review of bioregulator peptides and their epigenetic mechanisms.

Disclaimer

This information is for educational and research purposes only. Consult a healthcare professional before use.