KPV
Anti-Inflammatory Tripeptide | Alpha-MSH Fragment
KPV is a potent anti-inflammatory tripeptide derived from the C-terminal of alpha-MSH. It exhibits remarkable anti-inflammatory and antimicrobial properties without the pigmentation effects of full α-MSH, making it ideal for inflammation management.
Mechanism of Action
Enters cells and inhibits inflammatory pathways at the nuclear level, particularly NF-κB signaling. Reduces pro-inflammatory cytokines (TNF-α, IL-6) without causing immunosuppression like steroids.
Key Benefits
- Systemic anti-inflammatory effects
- No pigmentation/tanning effects
- Immune modulation without immunosuppression
- Potential for autoimmune conditions
- Gut health support
- Multiple delivery routes available
Inflammation
- Systemic Inflammation
Reduces TNF-α and IL-6 through NF-κB pathway inhibition.
- Autoimmune Modulation
May help balance overactive immune responses in autoimmune conditions.
- Joint Inflammation
Potential benefits for inflammatory arthritis through cytokine reduction.
Gut Health
- IBD Support
Demonstrated benefit in Crohn's disease and ulcerative colitis models.
- Intestinal Barrier Repair
Helps restore intestinal barrier function.
- Microbiome Balance
Selective antimicrobial activity preserves beneficial gut bacteria.
Skin Health
- Psoriasis/Dermatitis
Topical KPV reduced psoriatic markers by 60% and improved skin barrier function.
- Skin Inflammation
Reduces inflammatory skin conditions without systemic effects.
Subcutaneous injection provides systemic anti-inflammatory effects. Abdomen is preferred for gut-related issues.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| General anti-inflammatory | 200-300mcg | Once daily | SubQ |
| Active inflammation | 250mcg | Twice daily | SubQ |
| Autoimmune support | 500mcg | Once daily | SubQ |
| Acute flare-ups | 500mcg | 2x daily for 1 week, then reduce | SubQ |
Reconstitution Instructions
- KPV lyophilized powder
- Bacteriostatic water
- Insulin syringes
- Alcohol swabs
- 1 Clean vial with alcohol pad
- 2 Add 1mL bacteriostatic water to 1mg vial (1000mcg/mL)
- 3 Or add 2mL for 500mcg/mL concentration
- 4 Gently swirl - dissolves easily
- 5 Solution should be clear and colorless
- 6 Label with concentration and date
- 7 Refrigerate immediately
Enhanced gut healing and anti-inflammatory effects through complementary mechanisms.
Different mechanisms; can be combined safely.
Complementary antimicrobial and healing effects.
Both support immune function through different pathways.
Synergistic for skin health and regeneration.
Both are α-MSH related; KPV lacks pigmentation effects but monitor for cumulative effects.
Subtle reduction in inflammation, improved energy
Noticeable decrease in inflammatory symptoms
Improved gut function (if applicable), reduced pain/swelling
Significant improvement in inflammatory markers
Sustained benefits, improved quality of life
Common Side Effects
- Minimal to no side effects reported
- Does not cause immunosuppression like steroids
- No melanin production/tanning effects
- May temporarily reduce inflammation-related symptoms
Stop Signs - Discontinue if:
- Signs of infection (fever, chills) - very rare
- Severe injection site reactions
- Paradoxical inflammation increase
- Allergic reaction symptoms
- Unusual fatigue or weakness
Contraindications
- Known peptide allergies
- Active severe infections (theoretical)
- Pregnancy or breastfeeding (limited data)
Good Signs
- High purity >98%
- Clear, colorless solution after reconstitution
- Stable small peptide structure
- Certificate of analysis available
Warning Signs
- pH should be 5.5-7 for optimal stability
Bad Signs
- Visible particles indicate contamination/degradation
- Yellow coloration indicates oxidation/potency loss
- KPV in IBD Models(2019)
Demonstrated significant reduction in inflammatory markers and improved intestinal barrier function in IBD models.
- Anti-Inflammatory Mechanisms Study(2020)
KPV enters cells and directly inhibits NF-κB pathway, reducing TNF-α, IL-6, and other inflammatory cytokines.
- Psoriasis/Dermatitis Study(2021)
Topical KPV reduced psoriatic markers by 60% and improved skin barrier function.
- Antimicrobial Properties Study(2022)
Showed selective antimicrobial activity against pathogenic bacteria while preserving beneficial gut microbiota.
Disclaimer
This information is for educational and research purposes only. Consult a healthcare professional before use.