Humanin vs NAD+
Moderate Research vs Extensively Studied
synergistic Both support mitochondrial function and healthy aging.
Molecular Data
Humanin NAD+
Weight 2,687 Da 663.43 Da
Half-life ~30 minutes (mice), >4 hours (rats) 1-4 hours (intracellular)
Chain 24 amino acids —
Type Mitochondria-derived peptide Coenzyme
Key Benefits
Humanin
01 Potent neuroprotection against Alzheimer's and Parkinson's pathology
02 Extended lifespan in animal models (C. elegans)
03 Improved metabolic healthspan parameters
04 Reduced inflammatory markers
05 Cytoprotective effects across multiple cell types
06 Anti-apoptotic activity
07 Mitochondrial optimization and biogenesis
08 Protection against oxidative stress
NAD+
01 Restores mitochondrial function and ATP synthesis
02 Enhances glucose and fat metabolism
03 Improves oxygen utilization and endurance
04 Activates DNA repair mechanisms
05 Supports longevity pathways via sirtuins
06 Improves mental clarity and focus
Dosing Protocols
Humanin
1-5 mg per injection (0.5-2 mg for HNG analog) / 2-3 times weekly for sustained mitochondrial support
Neuroprotection 1-5 mg 2-3x weekly
Longevity/Anti-aging 1-3 mg 2x weekly
HNG analog 0.5-2 mg 2x weekly
NAD+
IV: 250-1000mg; IM/SubQ: 100-500mg; Intranasal: 25-50mg; Oral precursors: 100-500mg NMN/NR / IV: 1-2x weekly; IM/SubQ: 2-3x weekly; Intranasal: 1-2x daily; Oral: daily
IV Infusion 250-1000mg 1-2x weekly
IM/SubQ 100-500mg 2-3x weekly
Side Effects
Humanin
Injection site reactions
Mild fatigue initially
Headache (rare)
NAD+
Mild flushing during IV infusion
Temporary nausea
Contraindications
Active cancer (theoretical concern with anti-apoptotic effects)
Pregnancy or breastfeeding
Hypersensitivity to peptide components
IV administration requires medical supervision
Avoid alcohol during treatment
Maintain consistent dosing schedule
Research Evidence
Humanin NAD+
Status Moderate Research Extensively Studied
References 4 studies 4 studies
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.