Hexarelin vs Sermorelin
Well Studied vs Well Studied
monitor Mechanism-based · 47% Both Hexarelin and Sermorelin affect insulin sensitivity or blood glucose. Monitor fasting glucose and HbA1c. Consider adding an insulin sensitizer (metformin/berberine).
Molecular Data
Hexarelin Sermorelin
Weight 887 Da 3,358 Da
Half-life 1-2 hours 10-12 minutes
Chain 6 amino acids 29 amino acids
Type Synthetic hexapeptide GHRH analog
Key Benefits
Hexarelin
01 Most potent GHRP for GH stimulation
02 Powerful synergy with GHRH peptides
03 Cardioprotective effects via CD36 receptor
04 Enhanced muscle growth and strength
05 Improved fat metabolism
06 Better recovery and tissue repair
07 Maintains natural GH pulsatility
08 Stable against proteolytic enzymes
Sermorelin
01 FDA-proven efficacy
02 Maintains natural GH pulsatile patterns
03 Preserves pituitary function
04 1.26kg lean mass increase documented in elderly
05 IGF-1 mediated anabolic effects
06 Allows natural feedback regulation
Dosing Protocols
Hexarelin
100-200 mcg per injection / 2-3 times daily for optimal GH pulses
GH optimization 100 mcg 2-3x daily
Enhanced results 200 mcg 2-3x daily
With GHRH (synergy) 100 mcg each 2-3x daily
Cardioprotection 100-200 mcg 1-2x daily
Sermorelin
200-300mcg per dose (up to 500mcg for athletic performance) / Once daily at bedtime (aligns with natural GH pulse)
Anti-aging/Longevity 200-300mcg Once at bedtime
Athletic Performance 300-500mcg Once at bedtime
Body Composition 200mcg 5 days weekly
Combination Therapy 200mcg + GHRP Once daily
Side Effects
Hexarelin
Increased appetite (less than GHRP-6)
Water retention
Tingling or numbness
Tiredness after injection
Mild headache
Sermorelin
Injection site reactions (16.7% of patients - generally mild)
Nasal irritation (intranasal route)
Contraindications
Active cancer or history of cancer
Pregnancy or breastfeeding
Pituitary disorders
WADA prohibited for competitive athletes
Active malignancy
Pituitary tumors
Pregnancy
Research Evidence
Hexarelin Sermorelin
Status Well Studied Well Studied
References 4 studies 5 studies
Latest — November 2024
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.