IGF-1 LR3 vs PEG-MGF
limited vs limited
monitor Researched · 90% Both target IGF-1 pathways; combining risks receptor overstimulation. Reduce doses significantly if combined.
Molecular Data
IGF-1 LR3 PEG-MGF
Weight — ~2,888 Da
Half-life 20-30 hours 48-72 hours (via PEGylation)
Chain 83 amino acids 24 amino acids
Type Synthetic IGF-1 analog IGF-1Ec splice variant C-terminal peptide
Key Benefits
IGF-1 LR3
01 Approximately 3x more potent than native IGF-1
02 Promotes muscle hypertrophy and hyperplasia in animal models
03 15-20% lean mass gains observed in 4-week rat studies
04 Anti-catabolic effects preserve muscle during cachexia
05 20-30 hour half-life for sustained effects
PEG-MGF
01 Extended half-life through PEGylation
02 Satellite cell activation for muscle repair
03 Recovery support following mechanical stress
04 Potential neuroprotection against oxidative stress
Dosing Protocols
IGF-1 LR3
20-100 mcg daily (start low at 20-30 mcg) / Once daily, or split AM/PM for higher doses
Beginner Protocol 20-30mcg Once daily post-workout
Intermediate 40-60mcg Once daily
Advanced 80-100mcg Once or split AM/PM
Women's Protocol 10-20mcg Once daily
PEG-MGF
200-400mcg per injection / 2-3x weekly, ideally post-workout
General Recovery 200mcg 2-3x weekly
Targeted Muscle Recovery 200-400mcg Post-workout, 2-3x weekly
Injury Recovery 200-400mcg 2-3x weekly
Conservative Protocol 100-200mcg 2x weekly
Side Effects
IGF-1 LR3
Hypoglycemia (lasting up to 30 hours) - CRITICAL
Water retention
Joint stiffness
Muscle soreness
Increased pump during workouts
PEG-MGF
Injection site soreness
Mild fatigue
Contraindications
NEVER approved for human use - research chemical only
Cancer history or undiagnosed growths
May cause organ hypertrophy (heart, intestines)
WADA prohibited - causes failed drug tests
Any history of cancer or neoplastic disease
Pregnancy or breastfeeding
Uncontrolled diabetes or severe hyperglycemia
Research Evidence
IGF-1 LR3 PEG-MGF
Status limited limited
References 4 studies 3 studies
Latest November 2024 —
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.