TB-500 (Ac-LKKTETQ) vs Tesamorelin
Moderate Research vs FDA Approved
synergistic Mechanism-based · 47% TB-500 (Ac-LKKTETQ) and Tesamorelin work through complementary pathways. Growth hormone signaling supports tissue repair processes. A well-established combination in recovery protocols.
Molecular Data
TB-500 (Ac-LKKTETQ) Tesamorelin
Weight 844 Da 5,135.9 Da
Half-life Not precisely established; effects persist longer than 24 hours 26-38 minutes
Chain 7 amino acids 44 amino acids
Type Acetylated heptapeptide GHRH analog
Key Benefits
TB-500 (Ac-LKKTETQ)
01 Promotes wound healing
02 Enhances cell migration
03 Supports angiogenesis (new blood vessel formation)
04 Reduces inflammation
05 Promotes keratinocyte migration
06 Supports collagen deposition
07 Enhances tissue repair
08 Active region of thymosin beta-4
Tesamorelin
01 FDA-approved formulation
02 Selective visceral fat targeting (15-20% reduction)
03 Proven clinical efficacy
04 Standardized dosing
05 37% liver fat reduction in NAFLD
06 Preserved subcutaneous fat
Dosing Protocols
TB-500 (Ac-LKKTETQ)
2-2.5mg per injection / 2x weekly (e.g., Monday and Thursday)
Loading phase 2-2.5 mg 2x weekly for 4-6 weeks
Maintenance 2 mg Weekly or bi-weekly
Tesamorelin
1.4-2mg daily (FDA-approved: 2mg for HIV lipodystrophy) / Once daily (evening preferred for GH rhythm)
HIV Lipodystrophy (FDA-approved) 1.4mg Once daily
Visceral Fat Reduction 2mg Once daily
Anti-aging/Body Composition 1-2mg 5-7x weekly
NAFLD Treatment 2mg Once daily (12 months)
Cognitive Enhancement 1mg Once daily (20 weeks)
Side Effects
TB-500 (Ac-LKKTETQ)
Injection site reactions
Mild fatigue
Head rush (reported)
Tesamorelin
Injection site reactions (17%)
Joint pain (13%)
Water retention
Contraindications
Not authorized for medicinal use
Active cancer (theoretical concern)
Pregnancy or breastfeeding
Prohibited by WADA in sports
Active malignancy
Pituitary disorders
Pregnancy
Research Evidence
TB-500 (Ac-LKKTETQ) Tesamorelin
Status Moderate Research FDA Approved
References 4 studies 5 studies
Latest — June 2025
FDA Approved No Yes
This comparison is for educational and research purposes only. Consult a healthcare professional before use.