Humanin and SS-31 Interaction

Synergistic
Researched 95% confidence

Humanin and SS-31 have a synergistic interaction with 95% confidence. Both target mitochondrial function; may have additive benefits for cellular health. These compounds primarily affect different organ systems.

Compound Profiles

Humanin

Mitochondria-Derived Peptide | HN

Humanin exerts its effects through multiple mechanisms. It interacts with cell surface receptors including FPRL1 and CNTFR, activating PI3K/AKT signaling pathways that promote cell survival.

Half-life: ~30 minutes (mice), >4 hours (rats) Typical dose: 1-5 mg per injection (0.5-2 mg for HNG analog) longevity, cognitive
carcinogenic riskteratogenic
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SS-31

Mitochondrial-Targeted Peptide | Cardiolipin Protector

Selectively binds to cardiolipin in inner mitochondrial membrane, preventing lipid peroxidation and optimizing electron transport chain function. This improves ATP production and reduces oxidative damage at the mitochondrial level.

Half-life: ~2 hours Typical dose: 5-10mg general support, 10-40mg clinical/performance protocols longevity, metabolic
teratogenic
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Combined Organ Load

Brain
low
Pancreas
low

Shared Safety Flags

2x 2 compounds share the teratogenic safety flag (Humanin, SS-31). Monitor accordingly.

Frequently Asked Questions

Can I take Humanin with SS-31?

Yes, Humanin and SS-31 can generally be taken together. Both target mitochondrial function; may have additive benefits for cellular health.

Is Humanin and SS-31 safe together?

Based on documented research, this combination is considered synergistic. However, shared safety flags include: teratogenic. Monitor accordingly.

What are the interactions between Humanin and SS-31?

Both target mitochondrial function; may have additive benefits for cellular health. This assessment has 95% confidence and is based on documented research data.

How should I time Humanin and SS-31?

Humanin has a half-life of ~30 minutes (mice), >4 hours (rats) and SS-31 has a half-life of ~2 hours. No specific timing requirements identified for this combination, but separating administration can help monitor individual effects.

Check this pair in the full Interaction Checker Full comparison: Humanin vs SS-31

This interaction analysis is compiled from research literature and pharmacological mechanism data. Always consult a healthcare professional before combining compounds.