Ipamorelin vs TB-500 (Ac-LKKTETQ)
Well Studied vs Moderate Research
synergistic Mechanism-based · 47% Ipamorelin and TB-500 (Ac-LKKTETQ) work through complementary pathways. Growth hormone signaling supports tissue repair processes. A well-established combination in recovery protocols.
Molecular Data
Ipamorelin TB-500 (Ac-LKKTETQ)
Weight 711.85 Da 844 Da
Half-life ~2 hours Not precisely established; effects persist longer than 24 hours
Chain 5 amino acids 7 amino acids
Type Growth hormone secretagogue Acetylated heptapeptide
Key Benefits
Ipamorelin
01 Optimal GH stimulation with superior bioavailability
02 Body composition improvements (lean mass, fat loss)
03 Enhanced recovery and anti-aging effects
04 Minimal side effects compared to other GHRPs
05 No significant cortisol or prolactin elevation
06 Improved sleep quality
TB-500 (Ac-LKKTETQ)
01 Promotes wound healing
02 Enhances cell migration
03 Supports angiogenesis (new blood vessel formation)
04 Reduces inflammation
05 Promotes keratinocyte migration
06 Supports collagen deposition
07 Enhances tissue repair
08 Active region of thymosin beta-4
Dosing Protocols
Ipamorelin
200-300 mcg per injection / 1-3 times daily depending on goals (1x for longevity, 2-3x for performance)
General Health & Longevity 200mcg 1x daily before bed
Body Composition 250-300mcg 2x daily (morning, pre-workout)
Athletic Performance 200-250mcg 2-3x daily
Sleep & Recovery 200mcg 1x daily 30min before bed
Anti-Aging Protocol 200-250mcg 1-2x daily
TB-500 (Ac-LKKTETQ)
2-2.5mg per injection / 2x weekly (e.g., Monday and Thursday)
Loading phase 2-2.5 mg 2x weekly for 4-6 weeks
Maintenance 2 mg Weekly or bi-weekly
Side Effects
Ipamorelin
Mild hunger increase 20-30 minutes post-injection
Slight drowsiness when taken before bed
Water retention (mild)
TB-500 (Ac-LKKTETQ)
Injection site reactions
Mild fatigue
Head rush (reported)
Contraindications
Pregnancy or breastfeeding
Active cancer or history of cancer
Severe kidney or liver disease
Not authorized for medicinal use
Active cancer (theoretical concern)
Pregnancy or breastfeeding
Prohibited by WADA in sports
Research Evidence
Ipamorelin TB-500 (Ac-LKKTETQ)
Status Well Studied Moderate Research
References 5 studies 4 studies
Latest October 2024 —
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.