Glutathione vs SS-31
Extensively Studied vs Well Studied
synergistic Both protect mitochondria; different mechanisms complement each other.
Molecular Data
Glutathione SS-31
Weight 307.32 Da —
Half-life ~10-14 minutes (IV) ~2 hours
Chain 3 amino acids —
Type Tripeptide Aromatic-cationic tetrapeptide
Key Benefits
Glutathione
01 Master antioxidant - protects against oxidative stress
02 Detoxification of heavy metals and toxins
03 Immune system support and T-cell function
04 Neuroprotective effects
05 Skin health and potential brightening effects
06 Liver protection and function
07 Mitochondrial support
08 Anti-aging properties
SS-31
01 Directly protects mitochondria
02 Improves cellular energy production (ATP)
03 Reduces oxidative damage
04 Enhances exercise capacity
05 Excellent safety profile in clinical trials
06 Cardioprotective effects
Dosing Protocols
Glutathione
100-600 mg injectable (100-200mg wellness, 200-600mg intensive); IV dosing higher (600-1400mg clinical) / 2-3 times weekly for subcutaneous; weekly for IV infusions
General wellness 100-200 mg 2-3x weekly
Intensive therapy 200-600 mg 2-3x weekly
Detoxification 600-1000 mg Weekly IV
Parkinson's support 1400 mg 2-3x weekly
SS-31
5-10mg general support, 10-40mg clinical/performance protocols / Once daily (morning or pre-workout for athletic use)
General mitochondrial support 5-10mg Once daily
Athletic performance 10-20mg Once daily pre-workout
Clinical protocols 40mg Once daily
Acute cardioprotection 0.25mg/kg/hr Continuous infusion
Side Effects
Glutathione
Injection site reactions
Mild nausea (usually with higher doses)
Abdominal cramping
SS-31
Excellent safety profile in clinical trials
No significant side effects reported at therapeutic doses
Mild injection site reactions possible
Safe for long-term use based on current data
Contraindications
Known allergy to glutathione
Pregnancy or breastfeeding (insufficient safety data)
Asthma (may trigger bronchospasm in some)
Known hypersensitivity to peptides
Pregnancy or breastfeeding (limited data)
Research Evidence
Glutathione SS-31
Status Extensively Studied Well Studied
References 4 studies 4 studies
Latest — February 2024
FDA Approved No No
This comparison is for educational and research purposes only. Consult a healthcare professional before use.