Best Peptides for Weight Loss

Peptides studied for appetite suppression, fat metabolism, and body weight reduction.

17 peptides ranked by research effectiveness

01

Retatrutide

Extensively Studied

Triple GLP-1/GIP/Glucagon Agonist | Weight Loss & Diabetes

Superior Weight Reduction most effective
Sustained Weight Management most effective
Triple Mechanism most effective
Half-life: ~6 days
02

Tirzepatide

FDA Approved

Dual GIP/GLP-1 Receptor Agonist | Weight Loss & Diabetes

Severe Obesity Management most effective
Metabolic Syndrome Reversal most effective
Body Composition Optimization effective
Half-life: ~5 days (120 hours)
03

Semaglutide

FDA Approved

GLP-1 Receptor Agonist | Weight Loss & Diabetes

Clinically Significant Weight Reduction most effective
Appetite and Craving Control most effective
Sustained Weight Maintenance effective
Half-life: ~7 days (168 hours)
04

Cagrilintide

Extensively Studied

Long-Acting Amylin Receptor Agonist | Weight Loss & Diabetes

Obesity (Monotherapy) effective
Obesity (CagriSema Combination) most effective
Weight Loss in Diabetic Patients most effective
Satiety Enhancement effective
Half-life: ~7 days (159-195 hours)
05

Survodutide

Extensively Studied

Dual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes

Obesity Without Diabetes most effective
Obesity With Type 2 Diabetes most effective
Sustained Weight Management most effective
Half-life: Approximately 6 days (109-115 hours)
06

Orforglipron

Extensively Studied

Oral Small-Molecule GLP-1 Receptor Agonist | Weight Loss & Diabetes

Obesity Without Diabetes most effective
Obesity With Type 2 Diabetes most effective
Cardiometabolic Risk Reduction effective
Prediabetes Prevention most effective
Half-life: 25-68 hours
07

Mazdutide

Extensively Studied

Dual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes

Severe Obesity Management most effective
Metabolic Syndrome Improvement most effective
Liver Fat Reduction most effective
Half-life: 6-8 days
08

Tesamorelin

FDA Approved

GHRH Analog | Visceral Fat Reduction

HIV-Associated Lipodystrophy most effective
Selective Visceral Fat Targeting most effective
Sustained Fat Loss effective
Lean Mass Preservation moderate
IGF-1 Elevation moderate
Half-life: 26-38 minutes
09

AOD-9604

Well Studied

Modified hGH Fragment | Fat Loss Peptide

Lipolysis Enhancement most effective
Lipogenesis Inhibition effective
Metabolic Safety effective
Half-life: 3-4 minutes
10

GHRP-6

Well Studied

Growth Hormone Releasing Peptide-6 | Hexapeptide GHS

Muscle Growth effective
Appetite Stimulation most effective
Recovery Enhancement effective
Half-life: 15-60 minutes
11

MK-677

Well Studied

Ghrelin Receptor Agonist | Oral Growth Hormone Secretagogue

Muscle Preservation most effective
Fat-Free Mass effective
Metabolic Rate effective
Half-life: ~24 hours
12

Adipotide

Emerging

Prohibitin-Targeting Peptidomimetic | Experimental Anti-Obesity

Adipose Mass Reduction most effective
Non-CNS Mechanism moderate
Half-life: Not established
13

HGH

FDA Approved

Human Growth Hormone | Somatropin

Fat Loss effective
Lean Mass effective
Recovery Enhancement effective
Half-life: 3-4 hours (SC), 20-30 minutes (IV)
14

GHRP-2

Well Studied

Growth Hormone Releasing Peptide-2 | Pralmorelin

Muscle Growth effective
Fat Metabolism effective
Recovery Enhancement effective
Half-life: ~30 minutes
15

CJC-1295 with DAC

Well Studied

Long-Acting Growth Hormone Releasing Hormone Analog | Extended Release

Fat Loss Enhancement effective
Lean Mass Gains effective
Half-life: 6-8 days
16

Ipamorelin

Well Studied

Growth Hormone Secretagogue | Selective GHRP

Lean Mass Development effective
Fat Loss Support effective
Half-life: ~2 hours
17

5-Amino-1MQ

preclinical

NNMT Inhibitor | Longevity & Metabolic Enhancement

Metabolic Rate Enhancement moderate
Fat Oxidation moderate
Half-life: 4-7 hours (3.8h IV, 6.9h oral)

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