Best Peptides for Metabolic Health

Peptides studied for metabolic function, insulin sensitivity, diabetes management, and energy metabolism.

23 peptides ranked by research effectiveness

01

Semaglutide

FDA Approved

GLP-1 Receptor Agonist | Weight Loss & Diabetes

Glycemic Control most effective
Cardiovascular Protection most effective
Beta Cell Preservation effective
Metabolic Syndrome Improvement effective
NASH/Fatty Liver moderate
Inflammation Reduction moderate
Half-life: ~7 days (168 hours)
02

Tirzepatide

FDA Approved

Dual GIP/GLP-1 Receptor Agonist | Weight Loss & Diabetes

Type 2 Diabetes Management most effective
Insulin Resistance Improvement effective
Beta Cell Preservation effective
Half-life: ~5 days (120 hours)
03

Retatrutide

Extensively Studied

Triple GLP-1/GIP/Glucagon Agonist | Weight Loss & Diabetes

Superior Glycemic Control most effective
Glucose-Dependent Regulation effective
Insulin Sensitivity effective
Half-life: ~6 days
04

MOTS-c

Well Studied

Mitochondrial-Derived Peptide | Metabolic Regulator

Insulin Resistance most effective
Type 2 Diabetes Support most effective
Obesity Prevention effective
Half-life: ~30 minutes
05

SLU-PP-332

Emerging

Synthetic Pan-ERR Agonist | Exercise Mimetic & Metabolic Modulator

Weight Loss & Body Composition most effective
Insulin Sensitivity & Glucose Control most effective
Energy Expenditure Enhancement most effective
Liver Health & NAFLD most effective
Half-life: Under investigation (no human PK data)
06

NAD+

Extensively Studied

Essential Cellular Coenzyme & Anti-Aging Therapy

Cellular Energy Production most effective
Metabolic Optimization most effective
Exercise Performance effective
Half-life: 1-4 hours (intracellular)
07

Survodutide

Extensively Studied

Dual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes

MASH Treatment most effective
Liver Fat Reduction most effective
Type 2 Diabetes Control effective
Half-life: Approximately 6 days (109-115 hours)
08

Mazdutide

Extensively Studied

Dual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes

Glycemic Control most effective
Dual Endpoint Achievement most effective
Half-life: 6-8 days
09

AICAR

limited

5-Aminoimidazole-4-carboxamide Ribonucleotide | AMPK Activator

AMPK Activation most effective
Fatty Acid Oxidation effective
Glucose Metabolism effective
Half-life: ~2-3 hours
10

Cagrilintide

Extensively Studied

Long-Acting Amylin Receptor Agonist | Weight Loss & Diabetes

Glycemic Control most effective
Insulin Sensitivity effective
Half-life: ~7 days (159-195 hours)
11

Orforglipron

Extensively Studied

Oral Small-Molecule GLP-1 Receptor Agonist | Weight Loss & Diabetes

Type 2 Diabetes Management most effective
Insulin Resistance Improvement effective
Half-life: 25-68 hours
12

L-Carnitine

established

Amino Acid Derivative | Fatty Acid Transporter

Fatty Acid Oxidation most effective
Energy Production effective
Weight Management moderate
Half-life: ~2-3 hours (injectable)
13

Tesamorelin

FDA Approved

GHRH Analog | Visceral Fat Reduction

Triglyceride Reduction effective
Cholesterol Profile Improvement effective
NAFLD Treatment effective
Half-life: 26-38 minutes
14

VIP

Extensively Studied

Vasoactive Intestinal Peptide | Neuropeptide

Diabetes Support moderate
Anti-Inflammatory effective
Sarcoidosis moderate
Half-life: 1-2 minutes
15

BAM-15

Moderate Research

Mitochondrial Uncoupler | Metabolic Enhancer

Obesity/Fat Loss effective
Insulin Resistance effective
Metabolic Syndrome moderate
Half-life: ~1.7 hours
16

5-Amino-1MQ

preclinical

NNMT Inhibitor | Longevity & Metabolic Enhancement

Energy Metabolism effective
Insulin Sensitivity effective
Metabolic Flexibility moderate
Half-life: 4-7 hours (3.8h IV, 6.9h oral)
17

Hexarelin

Well Studied

Examorelin | Synthetic Growth Hormone Secretagogue

Fat Metabolism effective
Body Composition effective
Half-life: 1-2 hours
18

Pancragen

Moderate Research

KEDW Tetrapeptide | Pancreas Bioregulator

Impaired Glucose Tolerance effective
Metabolic Syndrome moderate
Blood Sugar Regulation moderate
Half-life: Not established
19

Melanotan II

Well Studied

Synthetic Melanocortin Peptide | Tanning & Sexual Function

Appetite Suppression moderate
Fat Loss Support moderate
Half-life: ~2 hours
20

Cyclic Glycine-Proline

Moderate Research

IGF-1 Bioavailability Regulator & Neuroprotective Peptide

Type-2 Diabetes moderate
Blood Pressure Regulation moderate
Half-life: Extended stability (more stable than linear GPE precursor)
21

IGF-1 LR3

limited

Modified Growth Factor Analog | Muscle Growth

Nutrient Partitioning moderate
Fat Loss moderate
Half-life: 20-30 hours
22

Adipotide

Emerging

Prohibitin-Targeting Peptidomimetic | Experimental Anti-Obesity

Insulin Resistance effective
Half-life: Not established
23

Kisspeptin

Emerging

KISS1 Gene Product | Reproductive Neuropeptide

Energy Metabolism moderate
Half-life: ~4 minutes (KP-10), ~28-32 minutes (KP-54)

Browse by Goal

Healing & RecoveryWeight LossMetabolic HealthMuscle GrowthAnti-Aging & LongevityCognitive EnhancementMood & AnxietySleepImmune SupportGut HealthSkin & HairGrowth HormoneAnti-InflammatorySexual Health & FertilityMitochondrial HealthCardiovascularJoint & Bone Health